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Cited by 51Sleep and Wakefulness ResearchCircadian rhythm and melatoninNeuroscience of respiration and sleep

Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits

Kubota, Takeshi, Brown, Richard A., Fang, Jidong, Krueger, James M.·2001·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.2001.281.3.r1004
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Abstract

Interleukin (IL)-15 and -2 share receptor- and signal-transduction pathway (Jak-STAT pathway) components. IL-2 is somnogenic in rats but has not been tested in other species. Furthermore, the effects of IL-15 on sleep have not heretofore been described. We investigated the somnogenic actions of IL-15 in rabbits and compared them with those of IL-2. Three doses of IL-15 or -2 (10, 100, and 500 ng) were injected intracerebroventriculary at the onset of the dark period. In addition, 500 ng of IL-15 and -2 were injected 3 h after the beginning of the light period. IL-15 dose dependently increased non-rapid eye movement sleep (NREMS) and induced fever. IL-15 inhibited rapid eye movement sleep (REMS) after its administration during the light period; however, all doses of IL-15 failed to affect REMS if given at dark onset. IL-2 also dose dependently increased NREMS and fever. IL-2 inhibited REMS, and this effect was observed only in the light period. IL-15 and -2 enhanced electroencephalographic (EEG) slow waves during the initial 9-h postinjection period, then, during hours 10–23postinjection, reduced EEG slow-wave activity. Current data support the notion that the brain cytokine network is involved in the regulation of sleep.

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Crossref · 10.1152/ajpregu.2001.281.3.r1004

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  • The pro-inflammatory acting cytokines IFN-γ, IL-2, IL-6, IL-15, and IL-18 have NREM sleep-promoting actions in animal models.

    “the pro-inflammatory acting cytokines IFN-γ, IL-2, IL-6, IL-15, and IL-18 have NREM sleep-promoting actions in animal models (238, 306, 307, 309).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [307]

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Authors
Kubota, T., Brown, R. A., Fang, J., & Krueger, J. M.
Affiliations
  • Washington State University (US)
  • Pennsylvania State University (US)
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2001-09-01
Volume
281
Issue
3
Pages
R1004-R1012
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.2001.281.3.r1004
OpenAlex
W2181790751
Cited by
51
References
64
Citations by year
2026: 1 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r43ns036520-01)
  • National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, NS-36520, R01NS025378)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
IL-15, interleukin-2, NREM sleep, REM sleep, sleep regulation, cytokines, fever, EEG slow-wave activity, JAK/STAT signaling, intracerebroventricular administration, rabbits
MeSH terms
Animals, Circadian Rhythm, Dose-Response Relationship, Drug, Electroencephalography, Injections, Intraventricular, Interleukin-2, Male, Rabbits, Sleep Stages, Interleukin-15

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