Point:Counterpoint: Cardiovascular variability is/is not an index of autonomic control of circulation

Parati, Gianfranco; Mancia, Giuseppe; Rienzo, Marco Di; Castiglioni, Paolo

doi:10.1152/japplphysiol.00446.2006

Cited by 325Heart Rate Variability and Autonomic ControlCardiovascular and exercise physiologyCardiovascular Syncope and Autonomic Disorders

Point:Counterpoint: Cardiovascular variability is/is not an index of autonomic control of circulation

Open access

Parati, Gianfranco, Mancia, Giuseppe, Rienzo, Marco Di, Castiglioni, Paolo·2006·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00446.2006

Open this paper in CoChat — free account Open PDF

Abstract

PURPOSE AND SCOPE OF THE POINT:COUNTERPOINT DEBATES: This series of debates was initiated for the Journal of Applied Physiology because we believe an important means of searching for truth is through debate where contradictory viewpoints are put forward. This dialectic process whereby a thesis is advanced, then opposed by an antithesis, with a synthesis subsequently arrived at, is a powerful and often entertaining method for gaining knowledge and for understanding the source of a controversy. Before reading these Point:Counterpoint manuscripts or preparing a brief commentary on their content (see below for instructions), the reader should understand that authors on each side of the debate are expected to advance a polarized viewpoint and to select the most convincing data to support their position. This approach differs markedly from the review article where the reader expects the author to present balanced coverage of the topic. Each of the authors has been strictly limited in the lengths of both the manuscript (1,200 words) and the rebuttal (400). The number of references to publications is also limited to 30, and citation of unpublished findings is prohibited.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.00446.2006

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

These indices (LF component of HRV and systolic BP power spectra) can identify increased cardiac sympathetic activity despite their limitations.
“The α2-adrenergic antagonist yohimbine increased power in the low-frequency component of HRV and systolic BP power spectra, indicating that despite their limitations (35, 47), these indices can identify increased cardiac sympathetic activity.”
From Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans (2008) · cites this paper as [35]
In the HR variability section (page unavailable), the paper says LF HRV can reflect sympathetic cardiac modulation, particularly when cardiac sympathetic drive is activated, but it also reflects parasympathetic modulation. The BPV discussion in the same section says LF blood-pressure power responds to sympathetic cardiovascular influences, yet primarily reflects vasomotor tone and is not a specific marker of cardiac sympathetic activity. Thus the source supports the indices' qualified usefulness, but not treating both as identifiers of increased cardiac sympathetic activity. (LLM, conf=0.84)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog.
Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R., Pizzinelli, P., Sandrone, G., Malfatto, G., Dell'Orto, S., & Piccaluga, E. (1986) · Circulation Research · doi:10.1161/01.res.59.2.178 · Cited by 4,130 · see citing works
Decreased heart rate variability and its association with increased mortality after acute myocardial infarction
Kleiger, R. E., Miller, J. P., Bigger, J. T., & Moss, A. J. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90795-8 · Cited by 3,995 · see citing works
Cardiovascular neural regulation explored in the frequency domain.
Malliani, A., Pagani, M., Lombardi, F., & Cerutti, S. (1991) · Circulation · doi:10.1161/01.cir.84.2.482 · Cited by 3,569 · see citing works
Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120 · see citing works
Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt.
Montano, N., Ruscone, T. G., Porta, A., Lombardi, F., Pagani, M., & Malliani, A. (1994) · Circulation · doi:10.1161/01.cir.90.4.1826 · Cited by 1,108 · see citing works
Respiratory Sinus Arrhythmia
Yasuma, F., & Hayano, J.-I. (2004) · Chest · doi:10.1378/chest.125.2.683 · Cited by 907 · see citing works
Relationship Between Spectral Components of Cardiovascular Variabilities and Direct Measures of Muscle Sympathetic Nerve Activity in Humans
Pagani, M., Montano, N., Porta, A., Malliani, A., Abboud, F. M., Birkett, C. L., & Somers, V. K. (1997) · Circulation · doi:10.1161/01.cir.95.6.1441 · Cited by 876 · see citing works
Spectral Analysis of Blood Pressure and Heart Rate Variability in Evaluating Cardiovascular Regulation: A Critical Appraisal
Parati, G., Saul, J. P., Di Rienzo, M., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1276 · Cited by 849 · see citing works
Self-citation
Blood pressure and heart rate variabilities in normotensive and hypertensive human beings.
Mancia, G., Ferrari, A. U., Gregorini, L., Parati, G., Pomidossi, G. A., Bertinieri, G., Grassi, G. M., Rienzo, M. D., Pedotti, A., & Zanchetti, A. (1983) · Circulation Research · doi:10.1161/01.res.53.1.96 · Cited by 770 · see citing works
Self-citation
A CRITICAL APPRAISAL
Dave, K. A., & White, S. W. (2002) · World Highways/Routes du Monde · Cited by 767 · see citing works
Assessment of baroreceptor reflex sensitivity by means of spectral analysis.
Robbe, H. W. J., Mulder, L. J. M. M., Rüddel, H., Langewitz, W. A., Veldman, J. B. P., & Mulder, G. (1987) · Hypertension · doi:10.1161/01.hyp.10.5.538 · Cited by 745 · see citing works
Changes in autonomic regulation induced by physical training in mild hypertension.
Pagani, M., Somers, V. K., Furlan, R., Dell’Orto, S., Conway, J., Baselli, G., Cerutti, S., Sleight, P., & Malliani, A. (1988) · Hypertension · doi:10.1161/01.hyp.12.6.600 · Cited by 742 · see citing works
Transfer function analysis of the circulation: unique insights into cardiovascular regulation
Saul, J. P., Berger, R. D., Albrecht, P., Stein, S. P., Chen, M. H., & Cohen, R. J. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.4.h1231 · Cited by 728 · see citing works
Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans.
Parati, G., Rienzo, M. D., Bertinieri, G., Pomidossi, G. A., Casadei, R., Groppelli, A., Pedotti, A., Zanchetti, A., & Mancia, G. (1988) · Hypertension · doi:10.1161/01.hyp.12.2.214 · Cited by 616 · see citing works
Self-citation
How to measure baroreflex sensitivity
Parati, G., Rienzo, M. D., & Mancia, G. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018010-00003 · Cited by 515 · see citing works
Self-citation
Transfer function analysis of autonomic regulation. I. Canine atrial rate response
Berger, R. D., Saul, J. P., & Cohen, R. J. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.1.h142 · Cited by 501 · see citing works
Predicting Survival in Heart Failure Case and Control Subjects by Use of Fully Automated Methods for Deriving Nonlinear and Conventional Indices of Heart Rate Dynamics
Ho, K. K. L., Moody, G. B., Peng, C.-K., Mietus, J. E., Larson, M. G., Levy, D., & Goldberger, A. L. (1997) · Circulation · doi:10.1161/01.cir.96.3.842 · Cited by 489 · see citing works
Effect of rosary prayer and yoga mantras on autonomic cardiovascular rhythms: comparative study
Bernardi, L., Sleight, P., Bandinelli, G., Cencetti, S., Fattorini, L., Wdowczyc-Szulc, J., & Lagi, A. (2001) · BMJ · doi:10.1136/bmj.323.7327.1446 · Cited by 486 · see citing works
The application of methods of non-linear dynamics for the improved and predictive recognition of patients threatened by sudden cardiac death
Voss, A., Kurths, J., Kleiner, H. J., Witt, A., Wessel, N., Saparin, P. I., Osterziel, K. J., Schurath, R., & Dietz, R. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00008-9 · Cited by 474 · see citing works
Comparison of various techniques used to estimate spontaneous baroreflex sensitivity (the EuroBaVar study)
Laude, D., Elghozi, J., Girard, A., Bellard, E., Bouhaddi, M., Castiglioni, P., Cerutti, C., Cividjian, A., Rienzo, M. D., Fortrat, J., et al. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00709.2002 · Cited by 404 · see citing works
Self-citation
Spontaneous Cardiac Baroreflex in Humans
Parlow, J. L., Viale, J., Annat, G. J., Hughson, R. L., & Quintin, L. (1995) · Hypertension · doi:10.1161/01.hyp.25.5.1058 · Cited by 393 · see citing works
ELECTRONIC EVALUATION OF THE FETAL HEART RATE. VIII. PATTERNS PRECEDING FETAL DEATH, FURTHER OBSERVATIONS.
Hon, E. H., & Lee, S. T. (1963) · PubMed · Cited by 379 · see citing works
Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats
Bertinieri, G., DiRienzo, M., Cavallazzi, A., Ferrari, A. U., Pedotti, A., & Mancia, G. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.255.6.1-a · Cited by 315 · see citing works
Self-citation
Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats
Bertinieri, G., Rienzo, M. D., Cavallazzi, A., Ferrari, A. U., Pedotti, A., & Mancia, G. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.254.2.h377 · Cited by 312 · see citing works
Self-citation
Respiratory sinus arrhythmia in the denervated human heart
Bernardi, L., Keller, F., Sanders, M., Reddy, P. S., Griffith, B., Meno, F., & Pinsky, M. R. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.4.1447 · Cited by 272 · see citing works
Impact of Chronic Psychosocial Stress on Autonomic Cardiovascular Regulation in Otherwise Healthy Subjects
Lucini, D., Fede, G. D., Parati, G., & Pagani, M. (2005) · Hypertension · doi:10.1161/01.hyp.0000185147.32385.4b · Cited by 252 · see citing works
Self-citation
Sympathetic restraint of respiratory sinus arrhythmia: implications for vagal-cardiac tone assessment in humans
Taylor, J. A., Myers, C. W., Halliwill, J. R., Seidel, H., & Eckberg, D. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2804 · Cited by 249 · see citing works
Cardiac Baroreceptor Sensitivity Predicts Long-Term Outcome After Acute Ischemic Stroke
Robinson, T. G., Dawson, S., Eames, P. J., Panerai, R. B., & Potter, J. F. (2003) · Stroke · doi:10.1161/01.str.0000058493.94875.9f · Cited by 234 · see citing works
Time and frequency domain estimates of spontaneous baroreflex sensitivity provide early detection of autonomic dysfunction in diabetes mellitus
Frattola, A., Parati, G., Gamba, P., Paleari, F., Mauri, G., Rienzo, M. D., Castiglioni, P., & Mancia, G. (1997) · Diabetologia · doi:10.1007/s001250050851 · Cited by 213 · see citing works
Self-citation
Autonomic origin of heart rate fluctuations at the onset of muscular exercise
Fagraeus, L., & Linnarsson, D. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.40.5.679 · Cited by 179 · see citing works
Comparison Between Noninvasive Indices of Baroreceptor Sensitivity and the Phenylephrine Method in Post–Myocardial Infarction Patients
Pitzalis, M. V., Mastropasqua, F., Passantino, A., Massari, F., Ligurgo, L., Forleo, C., Balducci, C., Lombardi, F., & RIZZON, P. (1998) · Circulation · doi:10.1161/01.cir.97.14.1362 · Cited by 178 · see citing works
Relationship Between Muscle Sympathetic Nerve Activity and Diurnal Blood Pressure Profile
Narkiewicz, K., Winnicki, M., Schroeder, K. E., Phillips, B. G., Kato, M., Cwalina, E., & Somers, V. K. (2002) · Hypertension · doi:10.1161/hy1201.097302 · Cited by 176 · see citing works
Frequency-domain analysis of cerebral autoregulation from spontaneous fluctuations in arterial blood pressure
Panerai, R. B., Rennie, J. M., Kelsall, A. W. R., & Evans, D. H. (1998) · Medical & Biological Engineering & Computing · doi:10.1007/bf02522477 · Cited by 161 · see citing works
Cardiac Resynchronization Therapy Improves Heart Rate Variability in Patients with Symptomatic Heart Failure
Adamson, P. B., Kleckner, K. J., VanHout, W. L., Srinivasan, S., & Abraham, W. T. (2003) · Circulation · doi:10.1161/01.cir.0000083368.75831.7a · Cited by 159 · see citing works
Central Vagotonic Effects of Atropine Modulate Spectral Oscillations of Sympathetic Nerve Activity
Montano, N., Cogliati, C. B., Porta, A., Pagani, M., Malliani, A., Narkiewicz, K., Abboud, F. M., Birkett, C. L., & Somers, V. K. (1998) · Circulation · doi:10.1161/01.cir.98.14.1394 · Cited by 157 · see citing works
Methodology of spontaneous baroreflex relationship assessed by surrogate data analysis
Blaber, A. P., Yamamoto, Y., & Hughson, R. L. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.4.h1682 · Cited by 153 · see citing works
Dissociation of heart rate variability from parasympathetic tone
Goldberger, J. J., Ahmed, M. W., Parker, M. A., & Kadish, A. H. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.5.h2152 · Cited by 137 · see citing works
Heart rate variability as a prognostic tool in cardiology. A contribution to the problem from a theoretical point of view.
Moser, M., Lehofer, M., Sedminek, A., Lux, M., Zapotoczky, H. G., Kenner, T., & Noordergraaf, A. (1994) · Circulation · doi:10.1161/01.cir.90.2.1078 · Cited by 118 · see citing works
Fractal and Complexity Measures of Heart Rate Variability
Perkiömäki, J. S., Mäkikallio, T. H., & Huikuri, H. V. (2005) · Clinical and Experimental Hypertension · doi:10.1081/ceh-48742 · Cited by 117 · see citing works
Role of sinoaortic afferents in modulating BP and pulse-interval spectral characteristics in unanesthetized cats
Rienzo, M. D., Parati, G., Castiglioni, P., Omboni, S., Ferrari, A. U., Ramirez, A. J., Pedotti, A., & Mancia, G. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.6.h1811 · Cited by 111 · see citing works
Self-citation
Is respiratory sinus arrhythmia a good index of cardiac vagal tone in exercise?
Casadei, B., Moon, J., Johnston, J. A., Caiazza, A., & Sleight, P. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.2.556 · Cited by 108 · see citing works
Sympathetic overactivity in active ulcerative colitis: effects of clonidine
Furlan, R., Ardizzone, S., Palazzolo, L., Rimoldi, A., Perego, F., Barbic, F., Bevilacqua, M. T., Vago, L., Porro, G. B., & Malliani, A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00442.2005 · Cited by 106 · see citing works
Statical essays: Containing Haemastaticks
Hales, S., & Cournand, A. F. (1987) · Medical Entomology and Zoology · Cited by 100 · see citing works
Frequency response characteristics of sympathetically mediated vasomotor waves in humans
Stauss, H. M., Anderson, E. A., Haynes, W. G., & Kregel, K. C. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.4.h1277 · Cited by 100 · see citing works
Vaginal Intercourse Frequency and Heart Rate Variability
Brody, S., & Preut, R. (2003) · Journal of Sex & Marital Therapy · doi:10.1080/00926230390224747 · Cited by 81 · see citing works
Low-frequency arterial pressure fluctuations do not reflect sympathetic outflow: gender and age differences
Taylor, J. A., Williams, T. D., Seals, D. R., & Davy, K. P. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.4.h1194 · Cited by 81 · see citing works
Blood pressure and heart rate variability and baroreflex sensitivity before and after brain death
Conci, F. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.5.621 · Cited by 80 · see citing works
Effect of sinoaortic denervation on frequency-domain estimates of baroreflex sensitivity in conscious cats
Mancia, G., Parati, G., Castiglioni, P., & Rienzo, M. D. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.6.h1987 · Cited by 73 · see citing works
Self-citation
Effects of sino-aortic denervation on spectral characteristics of blood pressure and pulse interval variability: a wide-band approach
Rienzo, M. D., Castiglioni, P., Parati, G., Mancia, G., & Pedotti, A. (1996) · Medical & Biological Engineering & Computing · doi:10.1007/bf02520018 · Cited by 68 · see citing works
Self-citation
Dynamic interactions between arterial pressure and sympathetic nerve activity: role of arterial baroreceptors
Julien, C., Chapuis, B., Cheng, Y., & Barrès, C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00102.2003 · Cited by 57 · see citing works
Contrasting effects of phentolamine and nitroprusside on neural and cardiovascular variability
van de Borne, P., Rahnama, M., Mezzetti, S., Montano, N., Porta, A., Degaute, J.-P., & Somers, V. K. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.2.h559 · Cited by 51 · see citing works
Broadband Spectral Analysis of Blood Pressure and Heart Rate Variability in Very Elderly Subjects
Parati, G., Frattola, A., Rienzo, M. D., Castiglioni, P., & Mancia, G. (1997) · Hypertension · doi:10.1161/01.hyp.30.4.803 · Cited by 46 · see citing works
Self-citation
Turbulence dynamics: An independent predictor of late mortality after acute myocardial infarction
Bauer, A., Malík, M., Barthel, P., Schneider, R., Watanabe, M., Camm, A. J., Schömig, A., & Schmidt, G. P. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.02.037 · Cited by 38 · see citing works
Statical essays, containing haemastaticks, or, An account of some hydraulick and hydrostatical experiments made on the blood and blood vessels of animals : also an account of some experiments on stones in the kidneys and bladder : with an enquiry into the nature of those anomalous concretions : to which is added, an appendix, containing observations and experiments relating to several subjects in the first volume, the greater part of which were read at several meetings before the Royal Society : with an index to both volumes. Vol. II
Hales, S., Innys, W., Manby, R., & Woodward, T. (1733) · doi:10.5962/bhl.title.106596 · Cited by 36 · see citing works
Spontaneous beat-by-beat fluctuations of total peripheral and cerebrovascular resistance in response to tilt
O’Leary, D. D., Shoemaker, J. K., Edwards, M. R., & Hughson, R. L. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00408.2003 · Cited by 35 · see citing works
Effects of constant cardiac autonomic nerve stimulation on heart rate variability
Bailey, J., Fitzgerald, D. M., & Applegate, R. J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.6.h2081 · Cited by 33 · see citing works
Statical essays : containing haemastaticks; or, An account of some hydraulick and hydrostatical experiments made on the blood and blood-vessels of animals. ... With an index to both volumes
Hales, S. (1969) · Readex Microprint eBooks · Cited by 29 · see citing works
A noninvasive measure of baroreflex sensitivity without blood pressure measurement
Davies, C., Colhoun, H. M., Coats, A. J. S., Piepoli, M. F., & Francis, D. P. (2002) · American Heart Journal · doi:10.1067/mhj.2002.121263 · Cited by 29 · see citing works
Evaluation of spontaneous baroreflex sensitivity in conscious dogs.
Frankel, R. A., Metting, P. J., & Britton, S. L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019541 · Cited by 28 · see citing works
Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion
Moore, M. C., Cardin, S., Edgerton, D. S., Farmer, B., Neal, D. W., Lautz, M., & Cherrington, A. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00343.2003 · Cited by 28 · see citing works
A hypothesis: autonomic rhythms are reflected in growth lines of teeth in humans and extinct archosaurs
Appenzeller, O., Gunga, H.-C., Qualls, C., Furlan, R., Porta, A., Lucas, S. G., Heckert, A. B., Kirsch, K. A., Costa-Junqueira, M. A., Guillén, S. E., et al. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.10.003 · Cited by 21 · see citing works
Heart rate variability estimates of autonomic tone: relationship to mapping pathological and procedural stress responses in coronary disease
Hamaad, A., Lip, G. Y. H., & MacFadyen, R. J. (2004) · Annals of Medicine · doi:10.1080/07853890410015810 · Cited by 21 · see citing works
Canadians seek kidney transplants in poor countries
Spurgeon, D. (2001) · BMJ · doi:10.1136/bmj.322.7300.1446 · Cited by 20 · see citing works
Adrenergic vascular control
Mano, T. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199610000-00039 · Cited by 13 · see citing works
Linear and non-linear parameters of heart rate variability during static and dynamic exercise in a high-performance dinghy sailor.
Princi, T., Accardo, A., & Peterec, D. (2004) · PubMed · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance
Billman, G. E. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00026 · Cited by 1,401 · see citing works
The utility of low frequency heart rate variability as an index of sympathetic cardiac tone: A review with emphasis on a reanalysis of previous studies
Reyes del Paso, G. A., Langewitz, W., Mulder, L. J. M., van Roon, A., & Duschek, S. (2013) · Psychophysiology · doi:10.1111/psyp.12027 · Cited by 954 · see citing works
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
Claassen, J. A. H. R., Thijssen, D. H. J., Panerai, R. B., & Faraci, F. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00022.2020 · Cited by 947 · see citing works
A Quantitative Systematic Review of Normal Values for Short-Term Heart Rate Variability in Healthy Adults: REVIEW OF SHORT-TERM HRV VALUES
NUNAN, D., SANDERCOCK, G. R. H., & BRODIE, D. A. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02841.x · Cited by 874 · see citing works
Heart Rate Variability ? A Historical Perspective
Billman, G. E. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00086 · Cited by 786 · see citing works
The human sympathetic nervous system: its relevance in hypertension and heart failure
Parati, G., & Esler, M. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs041 · Cited by 538 · see citing works
Self-citation
Analysis of Heart Rate Variability and Implication of Different Factors on Heart Rate Variability
Tiwari, R., Kumar, R., Malik, S., Raj, T., & Punit, K. (2021) · Current Cardiology Reviews · doi:10.2174/1573403x16999201231203854 · Cited by 508 · see citing works
Hierarchy of individual calibration levels for heart rate and accelerometry to measure physical activity
Brage, S., Ekelund, U., Brage, N., Hennings, M. A., Froberg, K., Franks, P. W., & Wareham, N. J. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00092.2006 · Cited by 303 · see citing works
Assessment of cardiac autonomic modulation during graded head-up tilt by symbolic analysis of heart rate variability
Porta, A., Tobaldini, E., Guzzetti, S., Furlan, R., Montano, N., & Gnecchi‐Ruscone, T. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00006.2007 · Cited by 307 · see citing works
Heart rate variability measures: a fresh look at reliability
Pinna, G. D., Maestri, R., Toruński, A., Daniłowicz‐Szymanowicz, L., Szwoch, M., Rovere, M. T. L., & Raczak, G. (2007) · Clinical Science · doi:10.1042/cs20070055 · Cited by 262 · see citing works
Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training
Billman, G. E. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00534.2009 · Cited by 234 · see citing works
Heart rate variability in mice: a theoretical and practical guide
Thireau, J., Zhang, B., Poisson, D., & Babuty, D. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.040733 · Cited by 226 · see citing works
Central sympathetic overactivity: Maladies and mechanisms
Fisher, J. P., Young, C. N., & Fadel, P. J. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.02.003 · Cited by 202 · see citing works
Validity of Commonly Used Heart Rate Variability Markers of Autonomic Nervous System Function
Thomas, B. L., Claassen, N., Becker, P., & Viljoen, M. (2019) · Neuropsychobiology · doi:10.1159/000495519 · Cited by 195 · see citing works
Variables Influencing Heart Rate
Valentini, M., & Parati, G. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.05.004 · Cited by 192 · see citing works
Self-citation
Heart rate variability during total intravenous anesthesia: Effects of nociception and analgesia
Jeanne, M., Logier, R., Jonckheere, J. D., & Tavernier, B. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.01.005 · Cited by 183 · see citing works
“On the other hand, the determinants of HRV remain incompletely defined (Taylor and Studinger, 2006).”
Healthy properties of proanthocyanidins
de la Iglesia, R., Milagro, F. I., Campión, J., Boqué, N., & Martínez, J. A. (2010) · BioFactors · doi:10.1002/biof.79 · Cited by 177 · see citing works
Testing the autonomic nervous system
Freeman, R. L., & Chapleau, M. W. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52902-2.00007-2 · Cited by 161 · see citing works
Heart Rate Variability (HRV) Analysis: A Methodology for Organizational Neuroscience
Massaro, S., & Pecchia, L. (2016) · Organizational Research Methods · doi:10.1177/1094428116681072 · Cited by 160 · see citing works
Autonomic control of heart rate by metabolically sensitive skeletal muscle afferents in humans
Fisher, J. P., Seifert, T., Hartwich, D., Young, C. N., Secher, N. H., & Fadel, P. J. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.185470 · Cited by 137 · see citing works
“…validity of HR variability measures as indices of either cardiac parasympathetic or sympathetic activity remains controversial (Taylor et al. 2001; Taylor & Studinger, 2006) and the influence of pharmacological blockade on HR during PEI, as used by O’Leary (1993), has not been evaluated in humans.”
Method
Newborn Infant Pain Assessment Using Heart Rate Variability Analysis
Faye, P. M., Jonckheere, J. D., Logier, R., Kamgaing, É. K., Jeanne, M., Rakza, T., & Storme, L. (2010) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181ed1058 · Cited by 134 · see citing works
Coupled Oscillatros: Complex But Not Complicated Cardiovascular and Brain Interactions
Stefanovska, A. (2007) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/emb.2007.907088 · Cited by 131 · see citing works
Levels of agreement for RR intervals and short-term heart rate variability obtained from the Polar S810 and an alternative system
Nunan, D., Jakovljević, D. G., Donovan, G., Hodges, L. D., SANDERCOCK, G. R. H., & Brodie, D. A. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0742-6 · Cited by 123 · see citing works
Relationships of Cardiac Autonomic Function With Metabolic Abnormalities in Childhood Obesity
Kaufman, C. L., Kaiser, D. R., Steinberger, J., Kelly, A. S., & Dengel, D. R. (2007) · Obesity · doi:10.1038/oby.2007.619 · Cited by 121 · see citing works
Intra-abdominal Adiposity and Individual Components of the Metabolic Syndrome in Adolescence
Syme, C. A., Abrahamowicz, M., Leonard, G. T., Perron, M., Pitiot, A., Qiu, X., Richer, L., Totman, J. J., Veillette, S., Xiao, Y., et al. (2008) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.162.5.453 · Cited by 115 · see citing works
Synchronization of low-frequency oscillations in the human cardiovascular system
Karavaev, A. S., Prokhorov, M. D., Пономаренко, В. И., Kiselev, A. R., Gridnev, V. I., Игоревна, Р. Е., & Bezruchko, B. P. (2009) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/1.3187794 · Cited by 113 · see citing works
Daytime sleepiness and neural cardiac modulation in sleep‐related breathing disorders
Lombardi, C., Parati, G., Cortelli, P., Provini, F., Vetrugno, R., Plazzi, G., Vignatelli, L., Rienzo, M. D., Lugaresi, E., Mancia, G., et al. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00659.x · Cited by 111 · see citing works
Self-citation
Chaotic Signatures of Heart Rate Variability and Its Power Spectrum in Health, Aging and Heart Failure
Wu, G., Arzeno, N. M., Shen, L., Tang, D., Zheng, D.-A., Zhao, N., Eckberg, D. L., & Poon, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004323 · Cited by 107 · see citing works
“In recent years there has been increasing recognition that HRV may in fact represent a much more complex phenomenon reflecting the nonlinear fluctuations of cardiac-autonomic outflows [13,14,15] in a fractal [16,17] or entropic [17,18], perhaps chaotic manner [19,20,21,22].”
Effect of body posture on postexercise parasympathetic reactivation in men
Buchheit, M., Haddad, H. A., Laursen, P. B., & Ahmaidi, S. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048041 · Cited by 110 · see citing works
The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients
Frasure‐Smith, N., Lespérance, F., Irwin, M. R., Talajic, M. R., & Pollock, B. G. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.07.005 · Cited by 110 · see citing works
“Although we have used standard interpretations of various HRV measures as estimates of parasympathetic and sympathetic input, their precise meaning remains controversial, particularly for LF power (Berntson et al., 1997; Parati et al., 2006; Taylor and Studinger, 2006; Haensel et al., 2008).”
Method
Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans
Bharucha, A. E., Charkoudian, N., Andrews, C. N., Camilleri, M., Sletten, D., Zinsmeister, A. R., & Low, P. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00153.2008 · Cited by 98 · see citing works
“The 2-adrenergic antagonist yohimbine increased power in the low-frequency component of HRV and systolic BP power spectra, indicating that despite their limitations (35, 47), these indices can identify increased cardiac sympathetic activity.”
Background
A Common Variant of the FTO Gene Is Associated With Not Only Increased Adiposity but Also Elevated Blood Pressure in French Canadians
Pausová, Z., Syme, C. A., Abrahamowicz, M., Xiao, Y., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Smith, G. D., Šeda, O., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.857359 · Cited by 94 · see citing works
Heart‐rate and blood‐pressure variability during psychophysiological tasks involving speech: Influence of respiration
Beda, A., Jandre, F. C., Phillips, D. I. W., Giannella‐Neto, A., & Simpson, D. M. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00542.x · Cited by 94 · see citing works
Autonomic Impairment in Severe Traumatic Brain Injury: A Multimodal Neuromonitoring Study
Sykora, M., Czosnyka, M., Liu, X., Donnelly, J., Nasr, N., Diedler, J., Okoroafor, F., Hutchinson, P. J., Menon, D. K., & Smielewski, P. S. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001624 · Cited by 91 · see citing works
Symposium review: Scientific assessment of affective states in dairy cattle
Ede, T., Lecorps, B., von Keyserlingk, M. A. G., & Weary, D. M. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16325 · Cited by 92 · see citing works
“amplifying either or both branches of the autonomic system and observing the resulting cardiovascular variability (Parati et al., 2006).”
Background
Fiber bragg grating sensor based device for simultaneous measurement of respiratory and cardiac activities
Chethana, K., Prasad, A. S. G., Omkar, S. N., & Asokan, S. (2016) · Journal of Biophotonics · doi:10.1002/jbio.201500268 · Cited by 91 · see citing works
Heart Rate Variability and Cardiovascular Fitness: What We Know so Far
de Souza, H. C. D., Philbois, S. V., Veiga, A. C., & Aguilar, B. A. (2021) · Vascular Health and Risk Management · doi:10.2147/vhrm.s279322 · Cited by 95 · see citing works
“nomic modulation of the heart and not cardiac autonomic activity.(51) This is important because while cardiac sympa-”
Background
The influence of age and weight status on cardiac autonomic control in healthy children: A review
Eyre, E. L. J., Duncan, M. J., Birch, S. L., & Fisher, J. P. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.09.019 · Cited by 90 · see citing works
“…the physiological correlates of HRV indices are debated and importantly a robust HRV derived assessment of cardiac sympathetic activity is lacking (Taylor and Studinger, 2006; Task Force, 1996), albeit the use of LF:HF ratio has beenwidely use to estimate the relative contribution of cardiac…”
BackgroundMethod
Sex differences in carotid baroreflex control of arterial blood pressure in humans: relative contribution of cardiac output and total vascular conductance
Kim, A., Deo, S. H., Vianna, L. C., Balanos, G. M., Hartwich, D., Fisher, J. P., & Fadel, P. J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00772.2011 · Cited by 90 · see citing works
Changes in Autonomic Variables Following Two Meditative States Described in Yoga Texts
Telles, S., Bhat, R., Visweswaraiah, N. K., Manjunath, N. K., Kumar, S., & Subramanya, P. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0282 · Cited by 86 · see citing works
Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension
Fisher, J. P., & Fadel, P. J. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.047332 · Cited by 85 · see citing works
Time course analysis of baroreflex sensitivity during postural stress
Westerhof, B. E., Berecki‐Gisolf, J., Karemaker, J. M., Wesseling, K. H., Secher, N. H., & LIESHOUT, J. J. V. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01024.2005 · Cited by 84 · see citing works
Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity
Lerma, C., Martínez, A., Ruiz, N., Vargas, A., Infante, Ó., & Martínez‐Lavín, M. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3513 · Cited by 84 · see citing works
Short-term heart rate variability measures in students during examinations.
Tharion, E., Parthasarathy, S., & Neelakantan, N. (2009) · PubMed · Cited by 83 · see citing works
Influence of breathing frequency on the pattern of respiratory sinus arrhythmia and blood pressure: old questions revisited
Sin, P. Y. W., Galletly, D. C., & Tzeng, Y. C. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00036.2010 · Cited by 81 · see citing works
“Moreover, despite extensive research, it remains unclear as to whether RSA is driven by respiratory synchronous oscillations in blood pressure via the arterial baroreflex or whether RSA and blood pressure are independently related to respiration via nonbaroreflex mechanisms (4, 14, 17, 28, 41, 46).”
Background
Heart rate variability and implication for sport concussion
Bishop, S. A., Dech, R. T., Guzik, P., & Neary, J. P. (2017) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12487 · Cited by 82 · see citing works
The effect of orthostatic stress on multiscale entropy of heart rate and blood pressure
Turianiková, Z., Javorka, K., Baumert, M., Čalkovská, A., & Javorka, M. (2011) · Physiological Measurement · doi:10.1088/0967-3334/32/9/006 · Cited by 81 · see citing works
Increased cardio-respiratory coupling evoked by slow deep breathing can persist in normal humans
Dick, T. E., Mims, J. R., Hsieh, Y.-H., Morris, K. F., & Wehrwein, E. A. (2014) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2014.09.013 · Cited by 65 · see citing works
“For example, “Cardiovascular variability is/is not an index of autonomic control of circulation” was one of the earliest topics considered in Point:Counterpoint published by Journal of Applied Physiology ((Parati et al., 2006) and (Taylor and Studinger, 2006), respectively).”
Background
Investigating the relationship between cardiac interoception and autonomic cardiac control using a predictive coding framework
Owens, A. P., Friston, K. J., Low, D. A., Mathias, C. J., & Critchley, H. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.01.001 · Cited by 79 · see citing works
Omega-3 Polyunsaturated Fatty Acids and Heart Rate Variability
Christensen, J. H. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00084 · Cited by 76 · see citing works
Cardiac autonomic modulation and sleepiness: Physiological consequences of sleep deprivation due to 40 h of prolonged wakefulness
Glos, M., Fietze, I., Blau, A., Baumann, G., & Penzel, T. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.11.011 · Cited by 75 · see citing works
The Role of n-3 PUFAs in Preventing the Arrhythmic Risk in Patients with Idiopathic Dilated Cardiomyopathy
Nodari, S., Metra, M., Milesi, G., Manerba, A., Cesana, B. M., Gheorghiade, M., & Cas, L. D. (2008) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-008-6142-7 · Cited by 73 · see citing works
“The significance of PSA of HR variability is still discussed [37].”
Background
Reduced short-term complexity of heart rate and blood pressure dynamics in patients with diabetes mellitus type 1: multiscale entropy analysis
Trunkvalterova, Z., Javorka, M., Tonhajzerová, I., Javorkova, J., Lazarova, Z., Javorka, K., & Baumert, M. (2008) · Physiological Measurement · doi:10.1088/0967-3334/29/7/010 · Cited by 73 · see citing works
Measurement of Heart Rate Variability to Assess Pain in Sedated Critically Ill Patients: A Prospective Observational Study
Broucqsault-Dedrie, C., Jonckheere, J. D., Jeanne, M., & Nseir, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147720 · Cited by 73 · see citing works
Preadolescents' Somatic and Cognitive-Affective Depressive Symptoms Are Differentially Related to Cardiac Autonomic Function and Cortisol: The TRAILS Study
Bosch, N. M., Riese, H., Dietrich, A., Ormel, J., Verhulst, F. C., & Oldehinkel, A. J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181bc756b · Cited by 71 · see citing works
Breathing through an inspiratory threshold device improves stroke volume during central hypovolemia in humans
Ryan, K. L., Cooke, W. H., Rickards, C. A., Lurie, K. G., & Convertino, V. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00439.2007 · Cited by 71 · see citing works
“While it is clear that RRIHF oscillations reflect vagal cardiac control (38), the meaning of the RRILF oscillations remains controversial (47).”
Background
Heart rate variability analysis as an index of emotion regulation processes: Interest of the Analgesia Nociception Index (ANI)
Jonckheere, J. D., Rommel, D., Nandrino, J., Jeanne, M., & Logier, R. (2012) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2012.6346703 · Cited by 70 · see citing works
The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment
Billman, G. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.011 · Cited by 69 · see citing works
Functional Variation in the Androgen-Receptor Gene Is Associated With Visceral Adiposity and Blood Pressure in Male Adolescents
Pausová, Z., Abrahamowicz, M., Mahboubi, A., Syme, C. A., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Gaudet, D., & Paus, T. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.146720 · Cited by 65 · see citing works
High-Intensity Interval Exercise Improves Vagal Tone and Decreases Arrhythmias in Chronic Heart Failure
Guiraud, T., Labrunée, M., GAUCHER-CAZALIS, K., Despas, F., MEYER, P., Bosquet, L., Galès, C., Vaccaro, A., Bousquet, M., Galinier, M., et al. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182967559 · Cited by 65 · see citing works
“However, we remain cautious about our results since the large discussion on the limitations of spectral analysis in HRV (35).”
Background
The effect of orthostasis on recurrence quantification analysis of heart rate and blood pressure dynamics
Javorka, M., Turianiková, Z., Tonhajzerová, I., Javorka, K., & Baumert, M. (2008) · Physiological Measurement · doi:10.1088/0967-3334/30/1/003 · Cited by 64 · see citing works
Alterations in autonomic function and cerebral hemodynamics to orthostatic challenge following a mountain marathon
Murrell, C., Wilson, L. C., Cotter, J. D., Lucas, S. J. E., Ogoh, S., George, K., & Ainslie, P. N. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01396.2006 · Cited by 63 · see citing works
Heart rate variability and muscle sympathetic nerve activity response to acute stress: the effect of breathing
DeBeck, L. D., Petersen, S. R., Jones, K. E., & Stickland, M. K. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00246.2009 · Cited by 62 · see citing works
Comparison of effects of OSA treatment by MAD and by CPAP on cardiac autonomic function during daytime
Glos, M., Penzel, T., Schoebel, C., Nitzsche, G.-R., Zimmermann, S., Rudolph, C., Blau, A., Baumann, G., Jost‐Brinkmann, P., Rautengarten, S., et al. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1265-0 · Cited by 59 · see citing works
Beyond HRV: attractor reconstruction using the entire cardiovascular waveform data for novel feature extraction
Aston, P. J., Christie, M. I., Huang, Y. H., & Nandi, M. (2018) · Physiological Measurement · doi:10.1088/1361-6579/aaa93d · Cited by 59 · see citing works
Cohort Profile: The Saguenay Youth Study (SYS)
Pausová, Z., Paus, T., Abrahamowicz, M., Bernard, M., Gaudet, D., Leonard, G. T., Peron, M., Pike, G. B., Richer, L., Séguin, J. R., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw023 · Cited by 58 · see citing works
Respiratory–cardiovascular interactions
Fisher, J. P., Żera, T., & Paton, J. F. R. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-323-91534-2.00006-0 · Cited by 57 · see citing works
Autonomic Nervous System Changes in Men With Chronic Pelvic Pain Syndrome
Yilmaz, U., Liu, Y.-W., Berger, R. E., & Yang, C. C. (2007) · The Journal of Urology · doi:10.1016/j.juro.2007.01.144 · Cited by 55 · see citing works
Applying fractal analysis to short sets of heart rate variability data
Peña, M. A., Echeverría, J. C., García, M. T., & González-Camarena, R. (2009) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-009-0436-1 · Cited by 50 · see citing works
Hydrocortisone effects on cardiovascular variability in septic shock: A spectral analysis approach*
Aboab, J., Polito, A., Orlikowski, D., Sharshar, T., Castel, M., & Annane, D. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31816f48f2 · Cited by 52 · see citing works
Heart rate variability and target organ damage in hypertensive patients
Melillo, P., Izzo, R., LUCA, N. D., & Pecchia, L. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-105 · Cited by 51 · see citing works
Impact of Restless Legs Syndrome on Cardiovascular Autonomic Control
Bertisch, S. M., Muresan, C., Schoerning, L., Winkelman, J. W., & Taylor, J. A. (2016) · SLEEP · doi:10.5665/sleep.5528 · Cited by 51 · see citing works
Cardiovascular variability is/is not an index of autonomic control of circulation
Malliani, A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00562.2006 · Cited by 51 · see citing works
TRACKING CENTRAL HYPOVOLEMIA WITH ECG IN HUMANS
Ryan, K. L., Rickards, C. A., Ludwig, D. A., & Convertino, V. A. (2010) · Shock · doi:10.1097/shk.0b013e3181cd8cbe · Cited by 50 · see citing works
Heart rate variability analysis for newborn infants prolonged pain assessment
Jonckheere, J. D., Rakza, T., Logier, R., Jeanne, M., Jounwaz, R., & Storme, L. (2011) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2011.6091909 · Cited by 50 · see citing works
Cardiovascular and metabolic responses to tap water ingestion in young humans: does the water temperature matter?
Girona, M., Grasser, E. K., Dulloo, A. G., & Montani, J. P. (2014) · Acta Physiologica · doi:10.1111/apha.12290 · Cited by 49 · see citing works
Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure
Chan, G. S. H., Ainslie, P. N., Willie, C. K., Taylor, C. E., Atkinson, G., Jones, H., Lovell, N. H., & Tzeng, Y. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01407.2010 · Cited by 49 · see citing works
Autonomic compensation to simulated hemorrhage monitored with heart period variability
Cooke, W. H., Rickards, C. A., Ryan, K. L., & Convertino, V. A. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181760d0c · Cited by 50 · see citing works
Analysis of Reproducibility of Noninvasive Measures of Sympathetic Autonomic Control Based on Electrodermal Activity and Heart Rate Variability
Posada-Quintero, H. F., Dimitrov, T., Moutran, A., Park, S., & Chon, K. H. (2019) · IEEE Access · doi:10.1109/access.2019.2899485 · Cited by 51 · see citing works
Sympathetic nerve activity and heart rate variability during severe hemorrhagic shock in sheep
Batchinsky, A. I., Cooke, W. H., Kuusela, T., Jordan, B. S., Wang, J. J., & Cancio, L. C. (2007) · Autonomic Neuroscience · doi:10.1016/j.autneu.2007.03.004 · Cited by 48 · see citing works
The Royal Canadian Mounted Police (RCMP) study: Protocol for a prospective investigation of mental health risk and resilience factors
Carleton, R. N., Krätzig, G. P., Sauer-Zavala, S., Neary, J. P., Lix, L. M., Fletcher, A. J., Afifi, T. O., Brunet, A., Martin, R., Hamelin, K. S., et al. (2022) · Health Promotion and Chronic Disease Prevention in Canada · doi:10.24095/hpcdp.42.8.02 · Cited by 45 · see citing works
Chronic baroreflex activation restores spontaneous baroreflex control and variability of heart rate in obesity-induced hypertension
Iliescu, R., Tudorancea, I., Irwin, E. D., & Lohmeier, T. E. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00464.2013 · Cited by 46 · see citing works
Cardiovascular autonomic regulation, inflammation and pain in rheumatoid arthritis
Adlan, A., Zanten, J. V., Lip, G. Y. H., Paton, J. F. R., Kitas, G. D., & Fisher, J. P. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.09.003 · Cited by 46 · see citing works
“The LF/HF ratio has been used as an estimate of ‘ sympathovagal balance ’ , however this concept has been debated (Parati et al., 2006; Taylor and Studinger, 2006).”
Method
Heart rate variability and catecholamines during hypoglycemia and orthostasis
Vlček, M., Rádiková, Ž., Penesová, A., Květňanský, R., & Imrich, R. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.08.001 · Cited by 45 · see citing works
Reproducibility of heart rate variability parameters measured in healthy subjects at rest and after a postural change maneuver
Dantas, E. M., Gonçalves, C. P., Silva, A., Rodrigues, S. L., Ramos, M. S., Andreão, R. V., Pimentel, E. B., Lunz, W., & Mill, J. G. (2010) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2010007500101 · Cited by 45 · see citing works
Selective quantification of the cardiac sympathetic and parasympathetic nervous systems by multisignal analysis of cardiorespiratory variability
Chen, X., & Mukkamala, R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01061.2007 · Cited by 45 · see citing works
Linear and nonlinear parameters of heart rate variability in ischemic stroke patients
Constantinescu, V. A., Matei, D., Costache, V. S., Cuciureanu, D. I., & Georgescu, C. A. (2017) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2017.10.002 · Cited by 44 · see citing works
Low-frequency heart rate variability is related to the breath-to-breath variability in the respiratory pattern
Beda, A., Simpson, D. M., Carvalho, N. C., & Carvalho, A. R. S. (2014) · Psychophysiology · doi:10.1111/psyp.12163 · Cited by 43 · see citing works
Complexity of heartbeat interval series in young healthy trained and untrained men
Platiša, M. M., Mazic, S. D., Nestorović, Z., & Gal, V. (2008) · Physiological Measurement · doi:10.1088/0967-3334/29/4/002 · Cited by 42 · see citing works
Aerobic physical training has little effect on cardiovascular autonomic control in aging rats subjected to early menopause.
Tezini, G. C., Dias, D., & Souza, H. C. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.009 · Cited by 38 · see citing works
Influence of ageing on carotid baroreflex peak response latency in humans
Fisher, J. P., Kim, A., Young, C. N., Ogoh, S., Raven, P. B., Secher, N. H., & Fadel, P. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.177998 · Cited by 41 · see citing works
“The ratio between LF and HF has been proposed as a measure of the balance between the cardiac and sympathetic control of the heart (Task Force, 1996; Pagani et al. 1997), but this remains questionable (Taylor & Studinger, 2006).”
BackgroundMethod
Spontaneous Hemodynamic Oscillations during Human Sleep and Sleep Stage Transitions Characterized with Near-Infrared Spectroscopy
Näsi, T., Virtanen, J., Noponen, T., Toppila, J. P., Salmi, T. K., & Ilmoniemi, R. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025415 · Cited by 41 · see citing works
Fingertip photoplethysmographic waveform variability and systemic vascular resistance in intensive care unit patients
Middleton, P. M., Chan, G. S. H., Steel, E., Malouf, P. J., Critoph, C., Flynn, G. M., O’Lone, E., Celler, B. G., & Lovell, N. H. (2011) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-011-0749-8 · Cited by 41 · see citing works
Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies
Billman, G. E., Nishijima, Y., Belevych, A. E., Terentyev, D., Xu, Y., Haizlip, K. M., Monasky, M. M., Hiranandani, N., Harris, W. S., Gyorke, S., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01065.2009 · Cited by 40 · see citing works
Dynamic time-varying analysis of heart rate and blood pressure variability in cats exposed to short-term chronic intermittent hypoxia
Rey, S., Tarvainen, M. P., Karjalainen, P. A., & Iturriaga, R. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00070.2008 · Cited by 40 · see citing works
Effect of dietary omega-3 fatty acids on the heart rate and the heart rate variability responses to myocardial ischemia or submaximal exercise
Billman, G. E., & Harris, W. S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00140.2011 · Cited by 39 · see citing works
C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function
Buttgereit, J., Shanks, J. A., Li, D., Hao, G., Athwal, A., Langenickel, T., Wright, H., Gonçalves, A. C. D. C., Monti, J., Plehm, R., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw184 · Cited by 39 · see citing works
Abnormal cardiovascular sympathetic and parasympathetic responses to physical and emotional stimuli in depersonalization disorder
Owens, A. P., David, A. S., Low, D. A., Mathias, C. J., & Sierra‐Siegert, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00089 · Cited by 37 · see citing works
Heart rate variability after heart transplantation: A 10-year longitudinal follow-up study
Cornelissen, V., Vanhaecke, J., AUBERT, A. E., & Fagard, R. H. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.12.002 · Cited by 37 · see citing works
Normative values, reliability and sample size estimates in heart rate variability
SANDERCOCK, G. R. H. (2007) · Clinical Science · doi:10.1042/cs20070137 · Cited by 37 · see citing works

FINAL WORDS ON DEBATE "POINT: COUNTERPOINT CARDIOVASCULAR VARIABILITY IS/IS NOT AN INDEX OF AUTONOMIC CONTROL OF CIRCULATION"
Taylor, J. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00576.2006 · Cited by 10 · see citing works
Reply to Dr. Cysarz's comment on Point:Counterpoint “Cardiovascular variability is/is not an index of autonomic control of circulation”
Rienzo, M. D., Castiglioni, P., & Parati, G. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00087.2007 · Cited by 3 · see citing works
Self-citation
Point:Counterpoint Comments
Karemaker, J. M. (2016)
Cardiovascular variability is/is not an index of autonomic control of circulation
Pichon, A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01038.2006 · Cited by 6 · see citing works
Comment on Point:Counterpoint: “Cardiovascular variability is/is not an index of autonomic control of circulation”
Notarius, C. F., & Floras, J. S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00283.2007 · Cited by 2 · see citing works

Authors: Parati, G., Mancia, G., Rienzo, M. D., & Castiglioni, P.
Affiliations: University of Milano-Bicocca (IT)
IRCCS Istituto Auxologico Italiano (IT)
Don Carlo Gnocchi Foundation (IT)
ORCID: Parati, Gianfranco
Mancia, Giuseppe
Rienzo, Marco Di
Castiglioni, Paolo
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2006-08
Volume: 101
Issue: 2
Pages: 676-682
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00446.2006
OpenAlex: W2048348029
Cited by: 325
References: 67
Citations by year: 2026: 3 · 2025: 7 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 14 · 2018: 9 · 2017: 19 · 2016: 18 · 2015: 11 · 2014: 16 · 2013: 23 · 2012: 26
FWCI: 20.38
Type: journal article
Language: en
Open access: green
hdl.handle.net
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
IrInSubria (University of Insubria) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords: cardiovascular variability, autonomic control of circulation, heart rate variability, blood pressure variability, autonomic nervous system
MeSH terms: Animals, Autonomic Nervous System, Blood Circulation, Blood Pressure, Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Heart Rate, Homeostasis, Humans, Mathematics, Prognosis, Baroreflex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Point:Counterpoint: Cardiovascular variability is/is not an index of autonomic control of circulation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks