Effect of estradiol on tissue glycogen metabolism and lipid availability in exercised male rats
Abstract
The effect of 17 beta-estradiol 3-benzoate (10 micrograms.0.1 ml sunflower oil-1.100 g body wt-1) on exercise performance, tissue glycogen utilization, and lipid availability was determined in male rats. In experiment 1, estradiol or oil was administered 1 h or 1–6 days before a treadmill run to exhaustion. No differences in body weight between oil- and estradiol-administered animals were observed during the 6-day treatment. Animals receiving estradiol for 3–6 days ran significantly longer and completed more work than oil-administered animals. Significant degradation of red and white vastus muscle, myocardial, and liver glycogen was observed in all animals run to exhaustion. In experiment 2, animals were administered estradiol for 5 days and then run for 2 h. The submaximal run for 2 h significantly reduced tissue glycogen content in red and white vastus muscle, heart, and liver of oil-administered animals. The latter effect was attenuated in both vastus muscles, liver, and myocardial tissues in the estradiol-administered animals. Estradiol administration significantly increased plasma fatty acids and lowered plasma lactate during the submaximal run. These data indicate that when body weight remained constant between groups of male rats, estradiol administration for 3–6 days increased exercise performance. Furthermore, estradiol administration for 5 days resulted in greater lipid availability and less tissue glycogen utilization during submaximal running for 2 h.
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Animal studies demonstrate that estrogens (and perhaps progesterone) increase circulating growth hormone-cortisol levels.
“Animal studies demonstrate that estrogens (and perhaps progesterone) enhance the activity of lipoprotein lipase, increase circulating growth hormone-cortisol levels, and decreases circulating insulin levels [2, 1517].”
From The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women. (2000) · cites this paper as [2]
Animal studies demonstrate that estrogens (and perhaps progesterone) enhance the activity of lipoprotein lipase.
“Animal studies demonstrate that estrogens (and perhaps progesterone) enhance the activity of lipoprotein lipase, increase circulating growth hormone-cortisol levels, and decreases circulating insulin levels [2, 1517].”
From The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women. (2000) · cites this paper as [2]
Animal studies demonstrate that estrogens (and perhaps progesterone) decrease circulating insulin levels.
“Animal studies demonstrate that estrogens (and perhaps progesterone) enhance the activity of lipoprotein lipase, increase circulating growth hormone-cortisol levels, and decreases circulating insulin levels [2, 1517].”
From The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women. (2000) · cites this paper as [2]
Rodent studies indicate that estrogens increase muscle glycogen storage at rest and reduce glycogen utilization during prolonged submaximal exercise, primarily due to increased oxidation of free fatty acids as an energy source, which results in a glycogen sparing effect.
“Rodent studies indicate estrogens increase muscle glycogen storage at rest and reduce glycogen utilization during prolonged submaximal exercise, primarily due to the increased oxidation of free-fatty acids as an energy source, which results in a glycogen sparing effect [2].”
From The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women. (2000) · cites this paper as [2]
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No effect of short-term testosterone manipulation on exercise substrate metabolism in men
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- Authors
- Kendrick, Z. V., & Ellis, G. S.
- Affiliations
- Temple University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1991-11-01
- Volume
- 71
- Issue
- 5
- Pages
- 1694-1699
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2257228634
- Cited by
- 114
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 3 · 2022: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2015: 4 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- estradiol, exercise performance, glycogen metabolism, lipid availability, myocardial glycogen, liver glycogen, plasma fatty acids, plasma lactate, submaximal running, male rats
- MeSH terms
- Animals, Estradiol, Physical Exertion, Fatty Acids, Glycogen, Lipids, Male, Muscles, Myocardium, Physical Endurance, Rats, Inbred Strains, Lipid Metabolism, Rats
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