17β-Estradiol Supplementation Decreases Glucose Rate of Appearance and Disappearance with No Effect on Glycogen Utilization during Moderate Intensity Exercise in Men
Abstract
CONTEXT AND OBJECTIVE: Women use less carbohydrate during endurance exercise, as compared with men. In rodents, 17beta-estradiol (E2) supplementation robustly increases lipid use and lowers muscle and liver glycogen use during exercise. E2 supplementation has been found to influence substrate selection by decreasing glucose rate of appearance (Ra), disappearance (Rd), and metabolic clearance rate during exercise in humans; however, neither a change in total carbohydrate use nor a sparing of muscle glycogen was demonstrated. SUBJECTS AND METHODS: We investigated the effect of 8 d of E2 (2 mg/d) supplementation on glucose turnover and net muscle glycogen use in 11 men using a randomized, double-blind, placebo-controlled, crossover design. Subjects underwent primed constant infusion of [6,6-(2)H]glucose, and muscle biopsies were taken before and after 90 min of cycling at 65% maximal oxygen uptake. RESULTS: E2 supplementation decreased the respiratory exchange ratio (P = 0.03) and glucose Ra and Rd (both P = 0.04) during exercise, as compared with placebo. E2 supplementation lowered proglycogen (P < 0.05) and total glycogen (P = 0.04) concentration, as compared with placebo; however, there was no effect of E2 on net muscle glycogen use during exercise. CONCLUSIONS: These findings show that E2 supplementation alters fuel selection in exercising men by increasing lipid use and reducing carbohydrate use, glucose Ra (primarily liver glucose production), and Rd (primarily muscle glucose uptake). Furthermore, E2 reduces the basal level of total muscle glycogen, particularly the proglycogen form.
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Oestrogen acts primarily on the liver, decreasing glucose release to influence substrate metabolism during END.
“Collectively, these data suggest that oestrogen acts primarily on the liver, decreasing glucose release to influence substrate metabolism during END.”
From Sex‐based differences in endurance exercise muscle metabolism: impact on exercise and nutritional strategies to optimize health and performance in women (2016) · cites this paper as Devries et al. 2005
Short-term oestrogen supplementation, at doses mimicking follicular phase, luteal phase or supraphysiological oestrogen concentrations, administered to amenorrheic women or men decreases liver glucose output and muscle uptake.
“Short-term supplementation of oestrogen (doses to mimic follicular phase, luteal phase and supraphysiological oestrogen concentrations) administered to ammenorrhoeic women or to men decreased liver glucose output and muscle uptake (Ruby et al. 1997;Carter et al. 2001a;Devries et al. 2005)”
From Sex‐based differences in endurance exercise muscle metabolism: impact on exercise and nutritional strategies to optimize health and performance in women (2016) · cites this paper as Devries et al. 2005
Oestrogen supplementation increases plasma free fatty acid concentrations and lowers muscle glycogen content.
“Additionally, oestrogen supplementation has been found to increase plasma FFA concentrations (Ruby et al. 1997) and lower muscle glycogen content (Devries et al. 2005).”
From Sex‐based differences in endurance exercise muscle metabolism: impact on exercise and nutritional strategies to optimize health and performance in women (2016) · cites this paper as Devries et al. 2005
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- Authors
- Devries, M. C., Hamadeh, M. J., Graham, T. E., & Tarnopolsky, M. A.
- Affiliations
- McMaster University Medical Centre (CA)
- McMaster University (CA)
- University of Guelph (CA)
- Corresponding author
- Tarnopolsky, Mark A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-11
- Volume
- 90
- Issue
- 11
- Pages
- 6218-6225
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1979765945
- Cited by
- 77
- References
- 41
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 3 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Laboratories
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- glucose turnover, glucose appearance rate, muscle glycogen, substrate selection, endurance exercise, respiratory exchange ratio, men
- MeSH terms
- Adult, Body Weight, Double-Blind Method, Estradiol, Glucose, Glycogen, Humans, Male, Metabolic Clearance Rate, Exercise, Lactic Acid, Lipid Metabolism
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