Carbohydrate ingestion and glycogen utilization in different muscle fibre types in man

Tsintzas, O K; Williams, C; Boobis, L; Greenhaff, P

doi:10.1113/jphysiol.1995.sp021046

Cited by 117Muscle metabolism and nutritionCardiovascular and exercise physiologySports Performance and Training

Carbohydrate ingestion and glycogen utilization in different muscle fibre types in man

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Tsintzas, O K, Williams, C, Boobis, L, Greenhaff, P·1995·The Journal of Physiology

DOI 10.1113/jphysiol.1995.sp021046PMC PMC1156808

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Abstract

1. The effect of carbohydrate (CHO) ingestion on muscle glycogen utilization during exercise was examined on seven male subjects completing two 60 min treadmill runs at 70% maximum oxygen uptake (VO2,max), 1 week apart. On each occasion the subjects consumed either water or a 5.5% CHO-electrolyte solution immediately before and during exercise. Muscle samples were obtained from the vastus lateralis by needle biopsy before and immediately after exercise. Venous blood samples were also collected from an ante-cubital vein at rest and at 10, 20, 40 and 60 min into the run. 2. Higher blood glucose concentrations (P < 0.01) were observed throughout the run during the CHO trial compared with the water trial. Serum insulin concentration was only higher after 20 min of exercise (P < 0.01). 3. A 28% reduction in mixed glycogen utilization was observed as a result of CHO ingestion when compared with water ingestion (108.7 +/- 16.3 vs. 150.9 +/- 19.9 mmol (kg dry matter)-1, respectively; P < 0.01). 4. The ingestion of the CHO solution resulted in sparing of glycogen in type I (slow twitch) fibres only (38 +/- 7% degradation of glycogen as opposed to 66 +/- 3% during the water trial; P = 0.01).

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When ingesting carbohydrates during constant pace running, carbohydrate oxidation can be maintained, thus sparing muscle glycogen through preferential oxidation from this exogenous carbohydrate source, in particular type I muscle fibres.
“For example, when ingesting carbohydrates during constant pace running, carbohydrate oxidation can be maintained, thus sparing muscle glycogen through preferential oxidation from this exogenous carbohydrate source [25], in particular type I muscle fibres [74].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [25]

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Self-citation

Authors: Tsintzas, O. K., Williams, C., Boobis, L., & Greenhaff, P.
Affiliations: Loughborough University (GB)
ORCID: Greenhaff, P
Venue: The Journal of Physiology
Publisher: Wiley
Published: 1995-11-15
Volume: 489
Issue: 1
Pages: 243-250
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.1995.sp021046
PMC: PMC1156808
OpenAlex: W1982479833
Cited by: 117
References: 28
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 4 · 2013: 5 · 2012: 7
FWCI: 0.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: carbohydrate intake, muscle glycogen utilization, muscle fiber type, type I muscle fibers, fast-twitch muscle, physical activity, blood glucose, serum insulin, glycogen sparing, vastus lateralis, endurance running, carbohydrate-electrolyte solution
MeSH terms: Adult, Blood Glucose, Carbohydrates, Glycogen, Humans, Male, Muscles, Time Factors, Exercise, Muscle Fibers, Slow-Twitch

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Carbohydrate ingestion and glycogen utilization in different muscle fibre types in man

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