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Additive effect of contractions and insulin on GLUT-4 translocation into the sarcolemma

Gao, J., Ren, J., Gulve, E. A., Holloszy, J. O.·1994·Journal of Applied Physiology

DOI 10.1152/jappl.1994.77.4.1597

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Abstract

The maximal effects of insulin and muscle contractions on glucose transport are additive. GLUT-4 is the major glucose transporter isoform expressed in skeletal muscle. Muscle contraction and insulin each induce translocation of GLUT-4 from intracellular sites into the plasma membrane. The purpose of this study was to test the hypothesis that the incremental effect of contractions and insulin on glucose transport is mediated by additivity of the maximal effects of these stimuli on GLUT-4 translocation into the sarcolemma. Anesthetized rats were given insulin by intravenous infusion to raise plasma insulin to 2,635 +/- 638 microU/ml. The gastrocnemius-plantaris-soleus group was stimulated to contract via the sciatic nerve by using a protocol that maximally activates glucose transport. After treatment with insulin, contractions, or insulin plus contractions or no treatment, the gastrocnemius-plantaris-soleus muscle group was dissected out and was subjected to subcellular fractionation to separate the plasma membrane and intracellular membrane fractions. Insulin induced a 70% increase and contractions induced a 113% increase in the GLUT-4 content of the plasma membrane fraction. The effects of insulin and contractions were additive, as evidenced by a 185% increase in the GLUT-4 content of the sarcolemmal fraction. This finding provides evidence that the incremental effect of maximally effective insulin and contractile stimuli on glucose transport is mediated by additivity of their effects on GLUT-4 translocation into the sarcolemma.

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CARACTERIZAÇÃO DO TREINAMENTO FÍSICO EXPERIMENTAL DE ENDURANCE EM ESTEIRA ADAPTADA ATRAVÉS DE MARCADORES METABÓLICOS ENERGÉTICOS
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“…including; a) increases in GLUT4, a glucose transporter protein (Wallberg-Henriksson et al., 1988, Goodyear et al., 1991, Brozinick et al., 1994, Gao et al., 1994, Hansen et al., 1995, Lund et al., 1995, Kristiansen et al., 1996), b) reductions in fatty acid mobilization (Santamauro et al.,…”
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Effect of eccentric exercise on insulin resistance and skeletal muscle GLUT-4 protein expression of type Ⅱ diabetes rats
정영수, & 구민석 (2009) · Exercise Science · doi:10.15857/ksep.2009.18.1.53

Authors: Gao, J., Ren, J., Gulve, E. A., & Holloszy, J. O.
Affiliations: Washington University in St. Louis (US)
ORCID: Gao, J.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1994-10-01
Volume: 77
Issue: 4
Pages: 1597-1601
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1994.77.4.1597
OpenAlex: W1864159588
Cited by: 116
References: 0
Citations by year: 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 2
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 00078)
National Institute of Diabetes and Digestive and Kidney Diseases (DK20579, DK-18986, R01DK018986)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: GLUT4, glucose transporter translocation, skeletal muscle glucose transport, insulin, muscle contraction, additive effects, sarcolemma, plasma membrane, subcellular fractionation
MeSH terms: Animals, Cell Fractionation, Cell Membrane, Electrophoresis, Polyacrylamide Gel, Glucose, Insulin, Intracellular Membranes, Male, Monosaccharide Transport Proteins, Muscle Contraction, Muscle Proteins, Sarcolemma, Blotting, Western, Rats, Wistar, Muscle, Skeletal, Glucose Transporter Type 4, Rats

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Additive effect of contractions and insulin on GLUT-4 translocation into the sarcolemma

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