Cited by 102Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyAdipose Tissue and Metabolism

Exercise and GLUT4

Flores-Opazo, Marcelo, McGee, Sean L., Hargreaves, Mark·2020·Exercise and Sport Sciences Reviews

Abstract

The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the sarcolemma and t-tubule and, over the longer term, total GLUT4 protein content. Here, we review key aspects of GLUT4 biology in relation to exercise, with a focus on exercise-induced GLUT4 translocation, postexercise metabolism and muscle insulin sensitivity, and exercise effects on GLUT4 expression.

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Registry

Crossref · 10.1249/jes.0000000000000224

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158 of 158 references verified0 citation errors · 0 not checkable

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Authors
Flores-Opazo, M., McGee, S. L., & Hargreaves, M.
Affiliations
  • Laboratory of Exercise and Physical Activity Sciences, Department of Physiotherapy, University Finis Terrae, Santiago, Chile
  • Deakin University (AU)
  • The University of Melbourne (AU)
Corresponding author
Hargreaves, Mark
Venue
Exercise and Sport Sciences Reviews
Published
2020-07
Volume
48
Issue
3
Pages
110-118
ISSN
  • 0091-6331 (ISSN-L)
  • 1538-3008
OpenAlex
W3036769478
Cited by
102
References
158
Citations by year
2026: 20 · 2025: 17 · 2024: 17 · 2023: 15 · 2022: 22 · 2021: 10 · 2020: 1
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Locations
  • Exercise and Sport Sciences Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
GLUT4, glucose transporters, physical activity, skeletal muscle glucose uptake, insulin sensitivity, GLUT4 translocation, sarcolemma, T-tubules, GLUT4 expression, muscle contraction
MeSH terms
Animals, Glucose, Humans, Insulin Resistance, Muscle Contraction, Sarcolemma, Transcription, Genetic, Exercise, Muscle, Skeletal, Protein Transport, Glucose Transporter Type 4

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