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Cited by 7Acute Kidney Injury ResearchThermoregulation and physiological responsesRenal function and acid-base balance

Acute sodium bicarbonate supplementation reduces the increase in markers of acute kidney injury during physical work in the heat

Masoud, Abdulaziz A., Li, Zidong, Deyhle, Michael R., Siegler, Jason, Specht, Jonathan, McKenna, Zachary J., Mermier, Christine, Amorim, Fabiano·2025·European Journal of Applied Physiology
DOI 10.1007/s00421-025-05850-x
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Abstract

Introduction In response to metabolic acidosis, compensatory mechanisms are deployed by the kidney to maintain acid-base homeostasis. During physical work in the heat, kidney perfusion is reduced, and the metabolic cost of acid-base balance can make the kidneys more prone to acute kidney injury (AKI). Sodium bicarbonate ingestion (NaHCO 3 ) may reduce metabolic acidosis and the risk of developing AKI. Purpose We tested the hypothesis that acute NaHCO 3 supplementation reduces the increase in AKI markers during physical work in the heat. Methods In a randomized double-blinded placebo-controlled crossover design 8 participants (3 females) completed 2 h of walking at 65% of maximal heart rate in 40 °C and ~ 20% relative humidity (RH) with NaHCO 3 (0.2 g/kg) or a placebo. Urine samples collected pre- and 1 h post-physical work were assayed for insulin-like growth factor binding protein 7 (IGFBP7), tissue inhibitor of metalloproteinase 2 (TIMP-2), and neutrophil gelatinase-associated lipocalin (NGAL). Results The increase in IGFBP7 × TIMP-2 was lower with NaHCO 3 (Δ log 2.77 ± 1.40 [pg/min] 2 ) compared to placebo (Δ log 4.19 ± 1.77 [pg/min] 2 ) (interaction: p = 0.05). NGAL increased from pre to 1 h post in the placebo (Δ log 2.55 ± 0.99 pg/min) and NaHCO 3 (Δ log 1.94 ± 1.06 pg/min) trials (main effect of time: p Conclusion These findings suggest that acute NaHCO 3 supplementation may be a beneficial intervention for individuals attempting to mitigate AKI risk during physical wo…

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Crossref · 10.1007/s00421-025-05850-x

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  • Investigations that administered different doses provided 0.18 g/kg, 0.2 g/kg, 0.21-0.24 g/kg, 0.4 g/kg, 0.43 g/kg, or 0.6 g/kg.

    “Investigations that administered different doses provided 0.18 g/kg (Poffé, Wyns, et al. 2021), 0.2 g/kg (Masoud et al. 2025), 0.21–0.24 g/kg (Ramos‐Campo et al. 2023), 0.4 g/kg (S. F. McCarthy et al. 2024), 0.43 g/kg (Dalle et al. 2019), or 0.6 g/kg (Marcus et al. 2019).”

    From Gastrointestinal Symptoms Associated With Sodium Bicarbonate Supplementation Protocols: A Systematic Review (2026) · cites this paper as Masoud et al. 2025

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Authors
Masoud, A. A., Li, Z., Deyhle, M. R., Siegler, J., Specht, J., McKenna, Z. J., Mermier, C., & Amorim, F.
Affiliations
  • Jazan University (SA)
  • Christopher Newport University (US)
  • University of New Mexico (US)
  • Arizona State University (US)
  • Texas Health Dallas (US)
Corresponding author
Masoud, Abdulaziz A.
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2025-06-21
Volume
125
Issue
12
Pages
3619-3630
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-025-05850-x
OpenAlex
W4411506989
Cited by
6
References
56
Citations by year
2026: 5 · 2025: 1
FWCI
4.09
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Jazan University (GSSRD-25)
Topics
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
Keywords
sodium bicarbonate supplementation, acute kidney injury, heat stress, metabolic acidosis, acid-base balance, IGFBP7, TIMP-2, neutrophil gelatinase-associated lipocalin, kidney injury biomarkers, walking exercise
MeSH terms
Lipocalin-2, Adult, Double-Blind Method, Female, Hot Temperature, Humans, Male, Biomarkers, Sodium Bicarbonate, Cross-Over Studies, Insulin-Like Growth Factor Binding Proteins, Dietary Supplements, Tissue Inhibitor of Metalloproteinase-2, Acute Kidney Injury

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