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Cited by 98Exercise and Physiological ResponsesMuscle metabolism and nutritionSports Performance and Training

Carbohydrate supplementation affects blood granulocyte and monocyte trafficking but not function after 2.5 h or running

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Nieman, DC, Fagoaga, OR, Butterworth, DE, Warren, BJ, Utter, A, Davis, JM, Henson, DA, Nehlsen-Cannarella, SL·1997·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/66.1.153
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Abstract

This randomized, double-blind, placebo-controlled study was designed to determine the influence of carbohydrate supplementation on the granulocyte and monocyte response to 2.5 h of high-intensity running [76.7 +/- 0.4% of maximal oxygen consumption (VO2max)]. Thirty experienced marathon runners (VO2max 53.4 +/- 1.0 mL.kg-1.min-1, age 41.5 +/- 1.4 y) were randomly assigned to carbohydrate-supplement (n = 17) and placebo (n = 13) groups. Subjects rested for 10-15 min before a blood sample was taken at 0715, and then ingested 0.75 L carbohydrate beverage or placebo. At 0730 subjects began running at 75-80% of VO2max for 2.5 h, and drank 0.25 L carbohydrate or placebo fluid every 15 min. Immediately after the 2.5-h run (1000), another blood sample was taken, followed by 1.5-h, 3-h, and 6-h recovery samples. Carbohydrate supplementation had a significant effect compared with placebo on the pattern of change in plasma glucose and cortisol, and the blood concentration of neutrophils (F[14, 112] = 5.13, P = 0.001) and monocytes (F[14, 112] = 4.78, P = 0.001), but not on blood granulocyte and monocyte phagocytosis or oxidative burst activity after 2.5 h of intensive running.

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Crossref · 10.1093/ajcn/66.1.153

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  • Carbohydrate ingestion during exercise blunted the exercise-induced IL-6 response, the increase in lymphocyte number as well as the cortisol.

    “Carbohydrate ingestion during exercise blunted the exercise-induced IL-6 response, the increase in lymphocyte number as well as the cortisol (204, 205).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [204]

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Authors
Nieman, D., Fagoaga, O., Butterworth, D., Warren, B., Utter, A., Davis, J., Henson, D., & Nehlsen-Cannarella, S.
Affiliations
Appalachian State University (US)
Corresponding author
Nieman, DC
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1997-07
Volume
66
Issue
1
Pages
153-159
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/66.1.153
OpenAlex
W2115179956
Cited by
98
References
37
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
9.37
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
carbohydrate supplementation, granulocytes, monocytes, leukocyte migration, high-intensity running, marathon runners, neutrophils, phagocytosis, respiratory burst, plasma glucose, cortisol, post-exercise recovery
MeSH terms
Adult, Beverages, Blood Glucose, Carbohydrates, Double-Blind Method, Female, Granulocytes, Humans, Hydrocortisone, Immune System, Male, Middle Aged, Monocytes, Oxygen Consumption, Phagocytosis, Running, Carbohydrate Metabolism

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