The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle
Abstract
The cytokine interleukin-6 (IL-6) exerts it actions via the IL-6 receptor (IL-6R) in conjunction with the ubiquitously expressed gp130 receptor. IL-6 is tightly regulated in response to exercise, being affected by factors such as exercise intensity and duration, as well as energy availability. Although the IL-6 response to exercise has been extensively studied, little is known about the regulation of the IL-6R response. In the present study, we aimed to investigate the effect of exercise, training, and glycogen availability, factors known to affect IL-6, on the regulation of gene expression of the IL-6R in human skeletal muscle. Human subjects performed either 10 wk of training with an acute exercise bout before and after the training period, or a low-glycogen vs. normal-glycogen acute exercise trial. The IL-6R mRNA response was evaluated in both trials. In response to acute exercise, an increase in IL-6R mRNA levels was observed. Neither training nor intramuscular glycogen levels had an effect on the IL-6R mRNA response to exercise. However, after 10 wk of training, the skeletal muscle expressed a higher mRNA level of IL-6R compared with before training. The present study demonstrated that the IL-6R gene expression levels in skeletal muscle are increased in response to acute exercise, a response that is very well conserved, being affected by neither training status nor intramuscular glycogen levels, as opposed to IL-6. However, after the training period, IL-6R mRNA production was increased in skeletal muscle, suggesting a sensitization of skeletal muscle to IL-6 at rest.
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“In contrast, the muscular expression of the IL-6 receptor (IL-6R) is elevated in trained human muscle (57), suggesting that muscular sensitivity to IL-6 is increased by training adaptation.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [57]
In the citing paper
“in humans, chronic exercise training reduces plasma concentrations of IL-6; however, this effect could be partially mitigated by increased skeletal muscle mRNA expression of IL-6 receptor32.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [32]
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Cites
1 retracted
Interleukin‐6 receptor expression in contracting human skeletal muscle: regulating role of IL‐6
Keller, P., Penkowa, M., Keller, C., Steensberg, A., Fischer, C. P., Giralt, M., Hidalgo, J., & Pedersen, B. K. (2005) · The FASEB Journal · doi:10.1096/fj.04-3278fje · Cited by 77
Self-citationRetractedPrinciples of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · cited 2×
“Also the MAPK and the PI3K pathways are activated by binding of IL-6 to its receptor (25).”
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
An Overview of Real-Time Quantitative PCR: Applications to Quantify Cytokine Gene Expression
Giulietti, A., Overbergh, L., Valckx, D., Decallonne, B., Bouillon, R., & Mathieu, C. (2001) · Methods · doi:10.1006/meth.2001.1261 · Cited by 1,403
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095
Self-citationMuscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875
Self-citationInterleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767
Self-citationEvidence that interleukin-6 is produced in human skeletal muscle during prolonged running
Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.949bp.x · Cited by 673
Self-citationMuscle triglyceride utilization during exercise: effect of training
Hurley, B. F., Nemeth, P. M., Martin, W. H., Hagberg, J. M., Dalsky, G. P., & Holloszy, J. O. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.2.562 · Cited by 522
Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K., & Neufer, P. D. (2001) · The FASEB Journal · doi:10.1096/fj.01-0507fje · Cited by 514
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Items 101–178 of 178
sIL-6R Is Related to Weekly Training Mileage and Psychological Well-being in Athletes
Cullen, T., Thomas, A. W., Webb, R., Phillips, T., & Hughes, M. G. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001210 · Cited by 14
A Cytokine-based model for the pathophysiology of Long COVID symptomsPreprint
Low, R. N., Low, R. J., & Akrami, A. (2020) · doi:10.31219/osf.io/7gcnv · Cited by 14
Franchini, É., Lira, F. S., Júlio, U. F., Antunes, B. M., Agostinho, M. F., Shiroma, S. A., & Panissa, V. L. G. (2018) · International Journal of Performance Analysis in Sport · doi:10.1080/24748668.2018.1501993 · Cited by 12
Nieman, D. C., Zwetsloot, K. A., Lomiwes, D. D., Meaney, M. P., & Hurst, R. D. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00431 · Cited by 13
Neuroinflammation, cortical activity, and fatiguing behaviour during self-paced exercise
Vargas, N., & Marino, F. E. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2086-8 · Cited by 11
Effect of prolonged dynamic exercise on plasma adrenomedullin concentration in healthy young men.
Krzeminski, K., Mikulski, T., & Nazar, K. (2006) · PubMed · Cited by 11
Horváth, L., Pekár, M., Švagera, Z., Horká, V., Mráz, M., & Bužga, M. (2025) · Physiological Research · doi:10.33549/physiolres.935751 · Cited by 14
Pattamaprapanont, P., Muanprasat, C., Soodvilai, S., Srimaroeng, C., & Chatsudthipong, V. (2016) · The Review of Diabetic Studies · doi:10.1900/rds.2016.13.197 · Cited by 10
Minafra, A. R., Chadt, A., Rafii, P., Al‐Hasani, H., Behnke, K., & Scheller, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1028808 · Cited by 9
Halmos, T., & Suba, I. (2014) · Orvosi Hetilap · doi:10.1556/oh.2014.29959 · Cited by 9
[Immunometabolism of exercise and sedentary lifestyle].
Moreno‐Eutímio, M. A., & Acosta‐Altamirano, G. (2014) · PubMed · Cited by 9
Inflammatory Response 24 h Post-Exercise in Youth with Juvenile Idiopathic Arthritis
Rochette, E., Merlin, É., Hourdé, C., Evrard, B., Peraira, B., Echaubard, S., & Duché, P. (2018) · International Journal of Sports Medicine · doi:10.1055/a-0640-9063 · Cited by 9
Aktitiz, S., ATAKAN, M. M., Turnagöl, H. H., & Koşar, Ş. N. (2022) · Peptides · doi:10.1016/j.peptides.2022.170864 · Cited by 8
Efeitos de diferentes intensidades de exercício sobre a concentração sérica de interleucinas
Neves, P. R. D. S., Tenório, T. R. D. S., Muniz, M. T. C., Neto, L. M. D. V., Botero, J. P., Oyama, L. M., & do Prado, W. L. (2014) · Revista Brasileira de Educação Física e Esporte · doi:10.1590/1807-55092014000400545 · Cited by 9
Lutosławska, G. (2013) · Human Movement · doi:10.2478/v10038-012-0045-y · Cited by 8
Exercise-Associated Iron Deficiency
Goldstein, E. R. (2016) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000202 · Cited by 12
Ringleb, M., Javelle, F., Haunhorst, S., Bloch, W., Fennen, L., Baumgart, S., Drube, S., Reuken, P. A., Pletz, M. W., Wagner, H., et al. (2023) · medRxiv · doi:10.1101/2023.05.10.23289790 · Cited by 8
Berg, R. M. G. (2025) · The Journal of Physiology · doi:10.1113/jp289744 · Cited by 8
Xu, Y., Yang, Y., Song, H., Li, M., Shi, W., Yu, T., Lin, J., & Yu, Y. (2025) · Orthopaedic Surgery · doi:10.1111/os.14365 · Cited by 8
Health benefits of physical activity: What role does skeletal muscle-organ crosstalk play?
Powers, S. K., Goldstein, E. R., Lategan-Potgieter, R., Schrager, M. A., Skelton, M., & Demirel, H. A. (2025) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2025.02.010 · Cited by 7
Gavin, J. P., Myers, S., & Willems, M. E. T. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00383.2015 · Cited by 7
Skeletal Muscle as Endocrine Organ
Ma, M., Zhang, Z., Hai, B., & Zhang, Y. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_22 · Cited by 9
Quero-Calero, C. D., Abellán‐Aynés, O., Manonelles, P., & Ortega, E. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063421 · Cited by 7
Cytokines in Skeletal Muscle Growth and Decay
Orzechowski, A. (2017) · Springer eBooks · doi:10.1007/978-981-10-3292-9_5 · Cited by 7
Caldwell, L. K., Kraemer, W. J., Post, E. M., Volek, J. S., Focht, B. C., Newton, R. U., Häkkinen, K., & Maresh, C. M. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002906 · Cited by 8
Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers
Rochette, E., Duché, P., Hourdé, C., Evrard, B., Pereira, B., Echaubard, S., & Etienne, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/9365745 · Cited by 6
Effect of exercise therapy on cytokine secretion in the saliva of bedridden patients.
Iki, H., Sawa, S., Teranishi, T., Tomita, M., Nishii, K., & Yamada, K. (2016) · Journal of Physical Therapy Science · doi:10.1589/jpts.28.2871 · Cited by 5
Moro, T., Monaco, L., Naro, F., Reggiani, C., & Paoli, A. (2022) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004209 · Cited by 6
Bao, Z., Li, Z., Zhao, M., Wang, S., Liu, F., & Wang, H. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2548009 · Cited by 4
Sportmedizinische Grundlagen: Immunologische Beanspruchung durch körperliche Belastung
Puta, C., & Gabriel, H. H. W. (2021) · Springer eBooks · doi:10.1007/978-3-662-53386-4_20-1 · Cited by 3
Muscle-to-organ cross-talk mediated by interleukin 6 during exercise: a review
Rad, R. S., & Panahzadeh, F. (2023) · Sport Sciences for Health · doi:10.1007/s11332-023-01102-7 · Cited by 5
Pedersen, B. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_31 · Cited by 4
Self-citationEFFECT OF RESISTANCE TRAINING AND DETRAINING ON METABOLIC MARKERS
Kim, J.-K., Kang, S., & Park, K.-M. (2019) · Journal of Men s Health · doi:10.22374/jomh.v15i2.125 · Cited by 4
Gene expression profile of mouse masseter muscle after repetitive electrical stimulation
Ono, T., Maekawa, K., Sonoyama, W., Kojima, S., Tanaka, T., Clark, G. T., & Kuboki, T. (2009) · Journal of Prosthodontic Research · doi:10.1016/j.jpor.2009.09.001 · Cited by 3
Exercise Suppresses Appetite in Obesity: A Biochemical, Metabolic, and Molecular Approach
Razi, O., Zamani, N., de Moraes, C., Laher, I., & Hadjicharalambous, M. (2025) · Applied Sciences · doi:10.3390/app15116191 · Cited by 4
Li, H., & Thirupathi, A. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1639427 · Cited by 2
da Silva, E. P., Borges, L., Bachi, A. L. L., Hirabara, S. M., & Lambertucci, R. H. (2020) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2019.1711006 · Cited by 2
Withnall, E., Hazeldine, J., Llibre, A., Duggal, N. A., Lord, J. M., & Sardeli, A. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.20.607078 · Cited by 2
Damay, V. A., Setiawan, S., Lesmana, R., Akbar, M. R., Lukito, A. A., Tarawan, V. M., Martha, J. W., Nugroho, J., & Sugiharto, S. (2025) · Physical Activity and Health · doi:10.5334/paah.490 · Cited by 1
Sylviana, N., Karisa, P., Romadona, N. F., & Megantara, I. (2025) · Experimental Physiology · doi:10.1113/ep092970 · Cited by 1
Interleuquina-6 en la regulación de la ingesta energética post-ejercicio físico
Santos, J. L., Carmen Almada, F., & Smalley, S. V. (2013) · Revista chilena de nutrición · doi:10.4067/s0717-75182013000200013 · Cited by 2
PETROFSKY, J. S., Laymon, M. S., Lee, H., Khowailed, I. A., & Fisher, S. D. (2014) · Cited by 1
Toloee, M. E., Soh, K. G., Abdullah, M. N. H., & Samah, B. A. (2012) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · Cited by 1
Patrizi, R. M. (2008) · University Microfilms International eBooks · Cited by 1
Pedersen, B. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_31-1 · Cited by 1
Self-citationThe Cytokine Interleukin 6 (IL-6) as a Neural and Endocrine Regulator
Castro, K. E. N., Méndez-García, L. A., Solleiro-Villavicencio, H., & Morales‐Montor, J. (2018) · Advances in Neuroimmune Biology · doi:10.3233/nib-180143 · Cited by 1
Posont, R. J. (2019) · Lincoln (University of Nebraska) · Cited by 1
Broken Connections: The Evidence for Neuroglial Failure in ME/CFSPreprint
Renz‐Polster, H. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/ef3n4 · Cited by 1
Moodie, N. J. G. (2010) · KU ScholarWorks (The University of Kansas) · Cited by 1
The Short Review on Protein Markers in Sport and Fitness Exercises
Borcz, A., Wiącek, M., Zając, A., Broda, D., & Zubrzycki, I. Z. (2006) · Cited by 1
Exercise, Nutrition, and Inflammation
Kraakman, M. J., Whitham, M., & Febbraio, M. A. (2013) · Wiley eBooks · doi:10.1002/9781118692318.ch38
Role of interleukin-6 in states of metabolic health and disease
Holmes, A. G. (2010) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27354477
Organ-Specific Physiological Responses to Acute Physical Exercise and Long-Term Training
Garatachea, N., Berger, N. A., Lucía, A., Knuuti, J. M., HEINONEN, I. H. A., Kalliokoski, K. K., Hannukainen, J. C., Duncker, D. J., Nuutila, P., Bouchard, C., et al. (2015)
Dehrashid, K. A. (2016) · Journal of Research and Health
Abbey, E. L. (2009) · VTechWorks (Virginia Tech)
Environmental extremes and the immune response to exercise
Dolci, A. (2015) · Bangor University Research Portal (Bangor University)
Schroer, A. B. (2013) · JMU Scholoraly Commons (James Madison University)
Miguélez, P. R. (2014) · Buleria (Universidad de León) · doi:10.18002/10612/3388
The Anti-Inflammatory Effects of Vitamin D and Exercise
Forney, L. A. (2014) · Louisiana State University · doi:10.31390/gradschool_dissertations.3667
The role of central IL-6 signalling in the development of Type 2 diabetes
Yiannakas, A. (2016) · Discovery Research Portal (University of Dundee)
冠動脈疾患急性治療後の糖代謝異常患者におけるIL-6 の運動時急性応答
広大, 石., 湯口, 聡., 梨恵子, 垣., 拓也, 大., 智恵子, 武., 森沢, 知., & 一紀, 清. (2017) · 理学療法学 · doi:10.15063/rigaku.11305
Wright, C. L. (2009) · UA Campus Repository (The University of Arizona)
Novel aspects of exercise training to promote human metabolic health
Mancilla, R. (2022) · Research Publications (Maastricht University) · doi:10.26481/dis.20220210rm
Tytell, M., & Robinson, M. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731224239.793547139
Rodríguez, A. M., Bonet, M. L., & Ribot, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00026-2
Interleukin-6 in exhaustive exercises and its correlation to bacteremia: a pilot study
Elgharib, A. A., Khalifa, D. S., Khodeer, S. A., Mohsen, Y., & Masallat, D. T. A. (2022) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2022.2124343
Sportmedizinische Grundlagen: Immunologische Beanspruchung durch körperliche Belastung
Puta, C., & Gabriel, H. H. W. (2023) · Springer eBooks · doi:10.1007/978-3-662-53410-6_20
Das, U. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95469-3.00010-3
Sylviana, N., Romadona, N. F., Megantara, I., & Karisa, P. (2025) · Research Square · doi:10.21203/rs.3.rs-6270599/v1
Genetic Influences on Inflammation, Oxidative Stress, and Recovery in Sports Performance
Pires, C. M. R. (2025) · Springer eBooks · doi:10.1007/978-3-032-11647-5_5
Ferrer, B. (2013) · TDX (Tesis Doctorals en Xarxa)
Liu, W., Shang, L., Li, P., Yao, Y., Yin, H., Zhang, H., Liu, Z., & Guo, Y. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03170-8
Daigle, D., Creasy-Marrazzo, A., Gradoville, L., El-Guindy, A. S., Mukherjee, R., Das, S., Baral, B., Rousseau, B. A., Park, R., McIntosh, M. T., et al. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1014211
The role of interleukin-6 receptor in cardiovascular and cerebrovascular diseases
Zou, J., Wang, Z., Jiang, M., Yang, Y., Liu, R., Wu, J., Li, H., Wang, Y., & Cheng, S. (2026) · The Innovation Medicine · doi:10.59717/j.xinn-med.2026.100239
Srpčič, A., Miš, K., Gantar, B. Ž. B., Dolinar, K., Mjaaseth, U. N., Rustan, A. C., Kase, E. T., Lakota, K., Pirkmajer, K. P., & Pirkmajer, S. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00264.2026
Mills, D. E. (2013) · Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)
Metadata
- Authors
- Keller, C., Steensberg, A., Hansen, A. K., Fischer, C. P., Plomgaard, P., & Pedersen, B. K.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-12
- Volume
- 99
- Issue
- 6
- Pages
- 2075-2079
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2147235183
- Cited by
- 179
- References
- 32
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 16 · 2012: 8
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Research Centre
- Danmarks Grundforskningsfond
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- IL-6 receptor, skeletal muscle, physical activity, training, acute exercise, interleukin-6, gp130, energy availability
- MeSH terms
- Adaptation, Physiological, Adult, Physical Exertion, Gene Expression Regulation, Glycogen, Humans, Male, Physical Fitness, Exercise, Muscle, Skeletal, Receptors, Interleukin-6
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