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Cited by 5Exercise and Physiological ResponsesDysphagia Assessment and ManagementIntensive Care Unit Cognitive Disorders

Effect of exercise therapy on cytokine secretion in the saliva of bedridden patients.

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Iki, Hidemasa, Sawa, Shunji, Teranishi, Toshio, Tomita, Masao, Nishii, Kazuhiro, Yamada, Kouji·2016·Journal of Physical Therapy Science
DOI 10.1589/jpts.28.2871PMC PMC5088144
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Abstract

[Purpose] The number of bedridden patients requiring nursing care in Japan has increased sharply in recent years because of its aging population and advances in medical care and has become a major social issue. Because bedridden patients are susceptible to nursing and healthcare-associated pneumonia, it is very important to improve their immunocompetence. Therefore, the effect of exercise therapy on stimulation of cytokine secretion in the saliva of bedridden patients was investigated. [Subjects and Methods] The subjects of this study were bedridden patients admitted to nursing care facilities. They were instructed to perform active assistive movement in the supine and sitting positions, with vital signs used as an index of the exercise load. Thirty-five patients fulfilled the inclusion criteria, which included cerebrovascular disease as the main cause of being bedridden and at least 6 months since onset. Interleukins were measured by enzyme-linked immunosorbent assay as immune mediators. [Results] Vital signs improved significantly after therapeutic exercise intervention, and the IL-6, IL-8, IL-15, and IL-17 levels also increased significantly after the intervention. [Conclusion] The results demonstrated that measurement of saliva samples may offer a safe minimally invasive method of measuring immune response in bedridden patients. This study suggests that exercise therapy may hold promise as an effective means of improving immunity in bedridden patients and may contribute to preventing aspiration pneumonia and promoting spontaneous recovery.

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  • Risk factors such as increased inhalation, poor oral hygiene, and viral infection are related to the occurrence of respiratory infection.

    “These studies suggested that keen vigilance should be maintained against infections derived from the oral microbiome during infection by respiratory viruses and have uncovered risk factors such as increased inhalation, poor oral hygiene, and viral infection are related to the occurrence of respiratory infection (Pace and McCullough, 2010; Krone et al., 2014; Iki et al., 2016).”

    From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Iki et al., 2016

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Authors
Iki, H., Sawa, S., Teranishi, T., Tomita, M., Nishii, K., & Yamada, K.
Affiliations
Fujita Health University (JP)
Corresponding author
Yamada, Kouji
ORCID
Yamada, Kouji
Venue
Journal of Physical Therapy Science
Publisher
Society of Physical Therapy Science
Published
2016
Volume
28
Issue
10
Pages
2871-2876
ISSN
  • 0915-5287 (ISSN-L)
  • 2187-5626
DOI
10.1589/jpts.28.2871
PMC
PMC5088144
OpenAlex
W2546291030
Cited by
5
References
34
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2018: 1
FWCI
0.36
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Journal of Physical Therapy Science (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (26560314)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
exercise therapy, bedridden patients, interleukins, immunocompetence, nursing facilities, cerebrovascular disease, aspiration pneumonia prevention, vital signs

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