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Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle
Abstract
The cytokine interleukin-6 (IL-6) exerts it actions via the IL-6 receptor (IL-6R) in conjunction with the ubiquitously expressed gp130 receptor. IL-6 is tightly regulated in response to exercise, being affected by factors such as exercise intensity and duration, as well as energy availability. Although the IL-6 response to exercise has been extensively studied, little is known about the regulation of the IL-6R response. In the present study, we aimed to investigate the effect of exercise, training, and glycogen availability, factors known to affect IL-6, on the regulation of gene expression of the IL-6R in human skeletal muscle. Human subjects performed either 10 wk of training with an acute exercise bout before and after the training period, or a low-glycogen vs. normal-glycogen acute exercise trial. The IL-6R mRNA response was evaluated in both trials. In response to acute exercise, an increase in IL-6R mRNA levels was observed. Neither training nor intramuscular glycogen levels had an effect on the IL-6R mRNA response to exercise. However, after 10 wk of training, the skeletal muscle expressed a higher mRNA level of IL-6R compared with before training. The present study demonstrated that the IL-6R gene expression levels in skeletal muscle are increased in response to acute exercise, a response that is very well conserved, being affected by neither training status nor intramuscular glycogen levels, as opposed to IL-6. However, after the training period, IL-6R mRNA production was increased in skeletal muscle, suggesting a sensitization of skeletal muscle to IL-6 at rest.
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“In contrast, the muscular expression of the IL-6 receptor (IL-6R) is elevated in trained human muscle (57), suggesting that muscular sensitivity to IL-6 is increased by training adaptation.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [57]
In the citing paper
“in humans, chronic exercise training reduces plasma concentrations of IL-6; however, this effect could be partially mitigated by increased skeletal muscle mRNA expression of IL-6 receptor32.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [32]
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Metadata
- Authors
- Keller, C., Steensberg, A., Hansen, A. K., Fischer, C. P., Plomgaard, P., & Pedersen, B. K.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-12
- Volume
- 99
- Issue
- 6
- Pages
- 2075-2079
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2147235183
- Cited by
- 179
- References
- 32
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 16 · 2012: 8
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Research Centre
- Danmarks Grundforskningsfond
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- IL-6 receptor, skeletal muscle, physical activity, training, acute exercise, interleukin-6, gp130, energy availability
- MeSH terms
- Adaptation, Physiological, Adult, Physical Exertion, Gene Expression Regulation, Glycogen, Humans, Male, Physical Fitness, Exercise, Muscle, Skeletal, Receptors, Interleukin-6
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