CoChat
Sign Up
Cited by 102Cardiovascular and exercise physiologyMuscle metabolism and nutritionReproductive Health and Contraception

Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise

Suh, Sang-Hoon, Casazza, Gretchen A., Horning, Michael A., Miller, Benjamin F., Brooks, George A.·2003·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00693.2002
Open this paper in CoChat — free account

Abstract

We examined the effects of oral contraceptives (OC) on glucose flux and whole body substrate oxidation rates during rest (90 min) and two exercise intensities [60-min leg ergometer cycling at 45 and 65% peak O 2 uptake (V˙o 2 peak)]. Eight healthy, eumenorrheic women were studied during the follicular and luteal phases before OC and the inactive and high-dose phases after 4 mo of a low-dose, triphasic OC. Subjects were studied in the morning 3 h after a standardized (308 kcal) breakfast. There were significant reductions in glucose rates of appearance and disappearance during exercise of both intensities with OC but not rest. There were no phase effects on substrate oxidation during rest or exercise. These results are interpreted to mean that, in women fed several hours before study, 1) OC decreases glucose flux, but not overall carbohydrate and lipid oxidation rates during moderate-intensity exercise; and 2) synthetic ovarian hormone analogs in the doses contained in OC have greater metabolic effects on glucose metabolism during exercise than do endogenous ovarian hormones.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.00693.2002

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In oral contraceptives, progestogens are insufficient to counteract the sodium-retaining effect of the estradiol component, so the estradiol component causes fluid retention.

    “in OCs, the progestogens are insufficient to counteract the sodium-retaining effect of the estradiol component; consequently, the estradiol component causes fluid retention [97].”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [97]

  • Women utilize more lipid than men, largely attributable to sex-specific hormonal influences and epigenetic adaptations to endurance exercise.

    “women utilize more lipid when compared to men and this is largely attributable to sex-specific hormonal influences and epigenetic adaptations to endurance exercise [86,175–177].”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [177]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Suh, S.-H., Casazza, G. A., Horning, M. A., Miller, B. F., & Brooks, G. A.
Affiliations
University of California, Berkeley (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2003-01-01
Volume
94
Issue
1
Pages
285-294
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00693.2002
OpenAlex
W2047024490
Cited by
102
References
40
Citations by year
2026: 1 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
14.40
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR42906, R01AR042906)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Keywords
oral contraceptives, glucose flux, substrate oxidation, exercise metabolism, carbohydrate oxidation, lipid oxidation, ovarian hormones, menstrual cycle phases, women
MeSH terms
Adult, Bicycling, Blood Glucose, Contraceptives, Oral, Estradiol, Female, Glucagon, Glucose, Humans, Insulin, Kinetics, Lactates, Longitudinal Studies, Oxidation-Reduction, Progesterone, Pulmonary Gas Exchange, Random Allocation, Rest, Exercise

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review