Role of Autophagy in COPD Skeletal Muscle Dysfunction
Abstract
Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by parenchymal damage and irreversible airflow limitation. In addition to lung dysfunction, patients with COPD develop weight loss, malnutrition, poor exercise performance, and skeletal muscle atrophy. The latter has been attributed to an imbalance between muscle protein synthesis and protein degradation. Several reports have confirmed that enhanced protein degradation and atrophy of limb muscles of COPD patient is mediated in part through activation of the ubiquitin-proteasome pathway and that this activation is triggered by enhanced production of reactive oxygen species. Until recently, the importance of the autophagy-lysosome pathway in protein degradation of skeletal muscles has been largely ignored, however, recent evidence suggests that this pathway is actively involved in recycling of cytosolic proteins, organelles, and protein aggregates in normal skeletal muscles. The protective role of autophagy in the regulation of muscle mass has recently been uncovered in mice with muscle-specific suppression of autophagy. These mice develop severe muscle weakness, atrophy, and decreased muscle contractility. No information is yet available about the involvement of the autophagy in the regulation of skeletal muscle mass in COPD patients. Pilot experiments on vastus lateralis muscle samples suggest that the autophagy-lysosome system is induced in COPD patients compared with control subjects. In this revi…
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Hussain and colleagues reported an increase in quadricipital LC3BII, Beclin-1, and p62/SQSTM1 at the protein level.
“By contrast, Hussain and colleagues reported an increase in quadricipital LC3BII, Beclin-1, and p62/SQSTM1 at the protein level [179].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [179]
Autophagy-induced lysosomal degradation is an essential process leading to degradation of cytoplasmic portions in lysosomes.
“A major other proteolytic pathway is autophagy-induced lysosomal degradation, an essential process leading to the degradation of cytoplasmic portions of variable sizes in the lysosomes (see the review by [179]).”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [179]
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- Authors
- Hussain, S. N. A., & Sandri, M.
- Affiliations
- McGill University Health Centre (CA)
- Veneto Institute of Molecular Medicine (IT)
- Corresponding author
- Hussain, Sabah N. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2013-05-01
- Volume
- 114
- Issue
- 9
- Pages
- 1273-1281
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2005001992
- Cited by
- 77
- References
- 76
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 11 · 2021: 4 · 2020: 8 · 2019: 2 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 6
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- chronic obstructive pulmonary disease, autophagy, autophagy-lysosome pathway, skeletal muscle atrophy, muscle protein degradation, muscle protein synthesis, ubiquitin-proteasome system, reactive oxygen species, muscle mass regulation, vastus lateralis, muscle dysfunction
- MeSH terms
- Animals, Autophagy, Humans, Models, Biological, Muscle Proteins, Signal Transduction, Muscle, Skeletal, Pulmonary Disease, Chronic Obstructive, Mice, Proteolysis
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