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Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics
Abstract
Patients with chronic obstructive pulmonary disease (COPD) have slowed pulmonary O 2 uptake (V̇o 2p) kinetics during exercise, which may stem from inadequate muscle O 2 delivery. However, it is currently unknown how COPD impacts the dynamic relationship between systemic and microvascular O 2 delivery to uptake during exercise. We tested the hypothesis that, along with slowed V̇o 2p kinetics, COPD patients have faster dynamics of muscle deoxygenation, but slower kinetics of cardiac output (Q̇t) following the onset of heavy-intensity exercise. We measured V̇o 2p, Q̇t (impedance cardiography), and muscle deoxygenation (near-infrared spectroscopy) during heavy-intensity exercise performed to the limit of tolerance by 10 patients with moderate-to-severe COPD and 11 age-matched sedentary controls. Variables were analyzed by standard nonlinear regression equations. Time to exercise intolerance was significantly ( P < 0.05) lower in patients and related to the kinetics of V̇o 2p( r = −0.70; P < 0.05). Compared with controls, COPD patients displayed slower kinetics of V̇o 2p(42 ± 13 vs. 73 ± 24 s) and Q̇t (67 ± 11 vs. 96 ± 32 s), and faster overall kinetics of muscle deoxy-Hb (19.9 ± 2.4 vs. 16.5 ± 3.4 s). Consequently, the time constant ratio of O 2 uptake to mean response time of deoxy-Hb concentration was significantly greater in patients, suggesting a slower kinetics of microvascular O 2 delivery. In conclusion, our data show that patients with moderate-to-severe COPD have impaired central and peripheral cardiovascular adjustments following the onset of heavy-intensity exercise. These cardiocirculatory disturbances negatively impact the dynamic matching of O 2 delivery and utilization and may contribute to the slower V̇o 2p kinetics compared with age-matched controls.
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“RND (and ventilatory demand) is often greatly increased in COPD because of the effect of increased wasted ventilation (high ventilation/perfusion ratios) [6,[56][57][58] and, in some instances, significant arterial hypoxemia and metabolic acidosis secondary to skeletal muscle deconditioning and/or poor O 2 delivery [6,59].”
From Lung hyperinflation in COPD: applying physiology to clinical practice (2015) · cites this paper as [59]
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“There is also evidence that impaired cardiac output response in the rest-to-exercise transition in non-hypoxemic patients with moderateto-severe COPD is associated with increased muscle deoxygenation thereby suggesting reduced muscle perfusion [59].”
From Lung hyperinflation in COPD: applying physiology to clinical practice (2015) · cites this paper as [59]
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Cited by
Chiappa, G. R., Queiroga, F., Meda, E., Ferreira, L. F., Diefenthaeler, F., Nunes, M., Vaz, M. A., Machado, M. C. L., Nery, L. E., & Neder, J. A. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200811-1793oc · Cited by 122
Self-citationLung hyperinflation in COPD: applying physiology to clinical practice
O’Donnell, D. E., Webb, K. A., & Neder, J. A. (2015) · COPD Research and Practice · doi:10.1186/s40749-015-0008-8 · Cited by 93
Self-citationLaveneziana, P., Palange, P., Ora, J., Martolini, D., & O’Donnell, D. E. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1169-4 · Cited by 60
Metadata
- Authors
- Chiappa, G. R., Borghi-Silva, A., Ferreira, L. F., Carrascosa, C., Oliveira, C. C., Maia, J., Gimenes, A. C., Queiroga, F., Berton, D., Ferreira, E. M. V., Nery, L. E., & Neder, J. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2008-05
- Volume
- 104
- Issue
- 5
- Pages
- 1341-1350
- ISSN
- 8750-7587
- 1522-1601
- Cited by
- 108
- References
- 4
- Language
- en
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- Chiappa, G. R., Borghi-Silva, A., Ferreira, L. F., Carrascosa, C., Oliveira, C. C., Maia, J., Gimenes, A. C., Queiroga, F., Berton, D., Ferreira, E. M. V., Nery, L. E., & Neder, J. A. (2008). Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.01364.2007
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