Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle

Percival, Michael E.; Martin, Brian J.; Gillen, Jenna B.; Skelly, Lauren E.; MacInnis, Martin J.; Green, Alex E.; Tarnopolsky, Mark A.; Gibala, Martin J.

doi:10.1152/japplphysiol.00048.2015

Cited by 50Muscle metabolism and nutritionExercise and Physiological ResponsesCardiovascular and exercise physiology

Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle

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Percival, Michael E., Martin, Brian J., Gillen, Jenna B., Skelly, Lauren E., MacInnis, Martin J., Green, Alex E., Tarnopolsky, Mark A., Gibala, Martin J.·2015·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00048.2015PMC PMC4669344

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Abstract

We tested the hypothesis that ingestion of sodium bicarbonate (NaHCO 3) prior to an acute session of high-intensity interval training (HIIT) would augment signaling cascades and gene expression linked to mitochondrial biogenesis in human skeletal muscle. On two occasions separated by ∼1 wk, nine men (mean ± SD: age 22 ± 2 yr, weight 78 ± 13 kg, V̇o 2 peak 48 ± 8 ml·kg−1·min−1) performed 10 × 60-s cycling efforts at an intensity eliciting ∼90% of maximal heart rate (263 ± 40 W), interspersed with 60 s of recovery. In a double-blind, crossover manner, subjects ingested a total of 0.4 g/kg body weight NaHCO 3 before exercise (BICARB) or an equimolar amount of a placebo, sodium chloride (PLAC). Venous blood bicarbonate and pH were elevated at all time points after ingestion ( P < 0.05) in BICARB vs. PLAC. During exercise, muscle glycogen utilization (126 ± 47 vs. 53 ± 38 mmol/kg dry weight, P < 0.05) and blood lactate accumulation (12.8 ± 2.6 vs. 10.5 ± 2.8 mmol/liter, P < 0.05) were greater in BICARB vs. PLAC. The acute exercise-induced increase in the phosphorylation of acetyl-CoA carboxylase, a downstream marker of AMP-activated protein kinase activity, and p38 mitogen-activated protein kinase were similar between treatments ( P > 0.05). However, the increase in PGC-1α mRNA expression after 3 h of recovery was higher in BICARB vs. PLAC (approximately sevenfold vs. fivefold compared with rest, P < 0.05). We conclude that NaHCO 3 before HIIT alters the mRNA expression of this key regulatory protein associated with mitochondrial biogenesis. The elevated PGC-1α mRNA response provides a putative mechanism to explain the enhanced mitochondrial adaptation observed after chronic HIIT supplemented with NaHCO 3 in rats.

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Sodium bicarbonate supplementation resulted in significantly higher levels of PGC-1-α, a key protein known to drive mitochondrial adaptations.
“Interestingly, Percival and investigators [499] reported that sodium bicarbonate supplementation resulted in significantly higher levels of PGC-1-α, a key protein known to drive mitochondrial adaptations.”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [499]
The Muscle Data section reports a significantly greater increase in PGC-1α mRNA after bicarbonate supplementation, but says the nuclear abundance of PGC-1α protein was not different at any point. The citing sentence describes higher levels of the protein, which is contrary to the reported protein result. (LLM, conf=0.86)
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Sodium bicarbonate promotes non-oxidative energy metabolism, as observed through greater muscle lactate production and muscle glycogen utilization during intermittent exercise performed in the severe-intensity domain.
“Evidence suggests that sodium bicarbonate promotes non-oxidative energy metabolism, as observed through greater muscle lactate production and muscle glycogen utilization during intermittent exercise performed in the severe-intensity domain (Percival et al., 2015).”
From Acute enteric-coated sodium bicarbonate has negligible effect on anaerobic performance but affects metabolomics and attenuates the gastrointestinal response (2022) · cites this paper as Percival et al., 2015
The Abstract reports greater muscle glycogen utilization and blood lactate accumulation with sodium bicarbonate during high-intensity interval cycling. The Blood and Muscle Metabolites section (page not supplied) explicitly says muscle lactate was not measured in this study, so the claimed observation of greater muscle lactate production is not supported. (LLM, conf=0.88)
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ISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945 · see citing works
“Interestingly, Percival and investigators [499] reported that sodium bicarbonate supplementation resulted in significantly higher levels of PGC-1-α, a key”
Background
Coordination of mitochondrial biogenesis by PGC-1α in human skeletal muscle: A re-evaluation
Islam, H., Edgett, B. A., & Gurd, B. J. (2018) · Metabolism · doi:10.1016/j.metabol.2017.11.001 · Cited by 99 · see citing works
Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle
Kitaoka, Y., Takeda, K., Tamura, Y., & Hatta, H. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0016 · Cited by 85 · see citing works
Recent Developments in the Use of Sodium Bicarbonate as an Ergogenic Aid
McNaughton, L. R., Gough, L. A., Deb, S. K., Bentley, D. J., & Sparks, S. A. (2016) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000283 · Cited by 83 · see citing works
A Single Bout of High-intensity Interval Exercise Increases Corticospinal Excitability, Brain-derived Neurotrophic Factor, and Uncarboxylated Osteolcalcin in Sedentary, Healthy Males
Nicolini, C., Michalski, B., Toepp, S. L., Turco, C. V., D'Hoine, T., Harasym, D., Gibala, M. J., Fahnestock, M., & Nelson, A. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.042 · Cited by 69 · see citing works
Self-citation
The effect of chronic progressive-dose sodium bicarbonate ingestion on CrossFit-like performance: A double-blind, randomized cross-over trial
Durkalec-Michalski, K., Zawieja, E. E., Podgórski, T., Łoniewski, I., Zawieja, B., Warzybok, M., & Jeszka, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197480 · Cited by 55 · see citing works
Effects of Dietary Supplements on Adaptations to Endurance Training
Rothschild, J. A., & Bishop, D. J. (2019) · Sports Medicine · doi:10.1007/s40279-019-01185-8 · Cited by 61 · see citing works
Effects of lactate administration on mitochondrial enzyme activity and monocarboxylate transporters in mouse skeletal muscle
Takahashi, K., Kitaoka, Y., Matsunaga, Y., & Hatta, H. (2019) · Physiological Reports · doi:10.14814/phy2.14224 · Cited by 48 · see citing works
Greater lactate accumulation following an acute bout of high-intensity exercise in males suppresses acylated ghrelin and appetite postexercise
Vanderheyden, L. W., McKie, G. L., Howe, G. J., & Hazell, T. J. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00081.2020 · Cited by 47 · see citing works
No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males
Nicolini, C., Toepp, S. L., Harasym, D., Michalski, B., Fahnestock, M. L., Gibala, M. J., & Nelson, A. J. (2019) · Physiological Reports · doi:10.14814/phy2.14140 · Cited by 42 · see citing works
Self-citation
Sodium bicarbonate supplementation improves severe-intensity intermittent exercise under moderate acute hypoxic conditions
Deb, S. K., Gough, L. A., Sparks, S. A., & McNaughton, L. R. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3801-7 · Cited by 38 · see citing works
The impact of work-matched interval training on VO2peak and VO2 kinetics: diminishing returns with increasing intensity
Raleigh, J. P., Giles, M. D., Scribbans, T. D., Edgett, B. A., Sawula, L. J., Bonafiglia, J. T., Graham, R. B., & Gurd, B. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0614 · Cited by 35 · see citing works
Determinants of curvature constant (W’) of the power duration relationship under normoxia and hypoxia: the effect of pre-exercise alkalosis
Deb, S. K., Gough, L. A., Sparks, S. A., & McNaughton, L. R. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3574-4 · Cited by 35 · see citing works
Characterization of the Human Skeletal Muscle Metabolome for Elucidating the Mechanisms of Bicarbonate Ingestion on Strenuous Interval Exercise
Saoi, M., Percival, M. E., Nemr, C. R., Li, A., Gibala, M. J., & Britz‐McKibbin, P. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00149 · Cited by 34 · see citing works
Self-citation
Effects of High-Intensity Interval Training Protocols on Blood Lactate Levels and Cognition in Healthy Adults: Systematic Review and Meta-Regression
Jacob, N., So, I., Sharma, B., Marzolini, S., Tartaglia, M. C., OH, P. I., & Green, R. (2023) · Sports Medicine · doi:10.1007/s40279-023-01815-2 · Cited by 37 · see citing works
Evolution of the use of sports supplements
Alonso, M. R., & Fernández‐Garcia, B. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100239 · Cited by 32 · see citing works
Factors Influencing AMPK Activation During Cycling Exercise: A Pooled Analysis and Meta-Regression
Rothschild, J. A., Islam, H., Bishop, D. J., Kilding, A. E., Stewart, T. I., & Plews, D. J. (2021) · Sports Medicine · doi:10.1007/s40279-021-01610-x · Cited by 32 · see citing works
Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA
Gurd, B. J., Menezes, E. S., Arhen, B. B., & Islam, H. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.05.016 · Cited by 31 · see citing works
High-intensity interval training enhances oxidative capacity and substrate availability in skeletal muscle
Hoshino, D., Kitaoka, Y., & Hatta, H. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.13 · Cited by 31 · see citing works
Post-exercise Supplementation of Sodium Bicarbonate Improves Acid Base Balance Recovery and Subsequent High-Intensity Boxing Specific Performance
Gough, L. A., Rimmer, S., Sparks, S. A., McNaughton, L. R., & Higgins, M. F. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00155 · Cited by 28 · see citing works
The influence of alkalosis on repeated high-intensity exercise performance and acid–base balance recovery in acute moderate hypoxic conditions
Gough, L. A., Brown, D., Deb, S. K., Sparks, S. A., & McNaughton, L. R. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3975-z · Cited by 28 · see citing works
The effects of sodium bicarbonate ingestion on cycling performance and acid base balance recovery in acute normobaric hypoxia
Gough, L. A., Deb, S. K., Brown, D., Sparks, S. A., & McNaughton, L. R. (2019) · Journal of Sports Sciences · doi:10.1080/02640414.2019.1568173 · Cited by 28 · see citing works
Oral Lactate Administration Additively Enhances Endurance Training-Induced Increase in Cytochrome C Oxidase Activity in Mouse Soleus Muscle
Takahashi, K., Kitaoka, Y., Yamamoto, K., Matsunaga, Y., & Hatta, H. (2020) · Nutrients · doi:10.3390/nu12030770 · Cited by 25 · see citing works
The influence of progressive-chronic and acute sodium bicarbonate supplementation on anaerobic power and specific performance in team sports: a randomized, double-blind, placebo-controlled crossover study
Durkalec-Michalski, K., Nowaczyk, P., Adrian, J., Kamińska, J., & Podgórski, T. (2020) · Nutrition and Metabolism · doi:10.1186/s12986-020-00457-9 · Cited by 25 · see citing works
A systematic upregulation of nuclear and mitochondrial genes is not present in the initial postexercise recovery period in human skeletal muscle
Scribbans, T. D., Edgett, B. A., Bonafiglia, J. T., Baechler, B. L., Quadrilatero, J., & Gurd, B. J. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0455 · Cited by 20 · see citing works
Effect of lactate administration on mouse skeletal muscle under calorie restriction
Shirai, T., Uemichi, K., Hidaka, Y., Kitaoka, Y., & Takemasa, T. (2021) · Current Research in Physiology · doi:10.1016/j.crphys.2021.09.001 · Cited by 21 · see citing works
Effects of lactate administration on hypertrophy and mTOR signaling activation in mouse skeletal muscle
Shirai, T., Kitaoka, Y., Uemichi, K., Tokinoya, K., Takeda, K., & Takemasa, T. (2022) · Physiological Reports · doi:10.14814/phy2.15436 · Cited by 16 · see citing works
The Effect of Beta-Alanine versus Alkaline Agent Supplementation Combined with Branched-Chain Amino Acids and Creatine Malate in Highly-Trained Sprinters and Endurance Athletes: A Randomized Double-Blind Crossover Study
Durkalec‐Michalski, K., Kusy, K., Ciekot-Sołtysiak, M., & Zieliński, J. (2019) · Nutrients · doi:10.3390/nu11091961 · Cited by 17 · see citing works
High-Intensity Intermittent Exercise and Autonomic Modulation: Effects of Different Volume Sessions
Castrillón, C. I. M., Miranda, R. A. T., Cabral‐Santos, C., Vanzella, L. M., Rodrigues, B., Vanderlei, L. C. M., Lira, F. S., & Campos, E. Z. (2017) · International Journal of Sports Medicine · doi:10.1055/s-0042-121898 · Cited by 15 · see citing works
Time course and fibre type‐dependent nature of calcium‐handling protein responses to sprint interval exercise in human skeletal muscle
Tripp, T. R., Frankish, B. P., Lun, V. M. Y., Wiley, J. P., Shearer, J. E., Murphy, R. M., & MacInnis, M. J. (2022) · The Journal of Physiology · doi:10.1113/jp282739 · Cited by 13 · see citing works
Self-citation
The effect of pre-exercise alkalosis on lactate/pH regulation and mitochondrial respiration following sprint-interval exercise in humans
Thomas, C., Delfour‐Peyrethon, R., Lambert, K., Granata, C., Hobbs, T., Hanon, C., & Bishop, D. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1073407 · Cited by 11 · see citing works
Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress
Bastola, T., Perkins, G. A., Huu, V. A. N., Ju, S., Kim, K.-Y., Shen, Z., Skowronska‐Krawczyk, D., Weinreb, R. N., & Ju, W. (2024) · Antioxidants · doi:10.3390/antiox13060743 · Cited by 10 · see citing works
The effects of sodium bicarbonate ingestion on swimming interval performance in trained competitive swimmers
Gough, L. A., Newbury, J. W., & Price, M. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05192-6 · Cited by 11 · see citing works
Influence of Sodium Citrate Supplementation after Dehydrating Exercise on Responses of Stress Hormones to Subsequent Endurance Cycling Time-Trial in the Heat
Suvi, S., Mooses, M., Timpmann, S., Medijainen, L., Unt, E., & Ööpik, V. (2019) · Medicina · doi:10.3390/medicina55040103 · Cited by 9 · see citing works
Effects of daily ingestion of sodium bicarbonate on acid-base status and anaerobic performance during an altitude sojourn at high altitude: a randomized controlled trial
Limmer, M., de Marées, M., & Platen, P. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00351-y · Cited by 9 · see citing works
Acute enteric-coated sodium bicarbonate has negligible effect on anaerobic performance but affects metabolomics and attenuates the gastrointestinal response
Zhou, N., Fan, Y., Wang, X., Wang, J., & Wu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.996381 · Cited by 8 · see citing works
“Evidence suggests that sodium bicarbonate promotes nonoxidative energy metabolism, as observed through greater muscle lactate production and muscle glycogen utilization during intermittent exercise performed in the severe-intensity domain (Percival et al., 2015).”
Background
Carbohydrate-Energy Replacement Following High-Intensity Interval Exercise Blunts Next-Day Glycemic Control in Untrained Women
Estafanos, S., Friesen, B., Govette, A., & Gillen, J. B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.868511 · Cited by 7 · see citing works
Self-citation
Activating soluble adenylyl cyclase protects mitochondria, rescues retinal ganglion cells, and ameliorates visual dysfunction caused by oxidative stressPreprint
Bastola, T., Perkins, G. A., Huu, V. A. N., Ju, S., Keun-young Kim, A., Shen, Z., Skowronska‐Krawczyk, D., Weinreb, R. N., & Ju, W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.04.583371 · Cited by 7 · see citing works
Finding the metabolic stress ‘sweet spot’: implications for sprint interval training‐induced muscle remodelling
Skelly, L. E., & Gillen, J. B. (2018) · The Journal of Physiology · doi:10.1113/jp276912 · Cited by 5 · see citing works
Self-citation
Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges
Álvarez, M. R., Alarcón, J. M., Roman, C. A. J., Lazaro, D. M., Bobrowski‐Khoury, N., Baena-Caldas, G. P., & Esber, G. R. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106525 · Cited by 5 · see citing works
Effect of Oral and Topical Sodium Bicarbonate on Functional Recovery and Soccer-Specific Performance After Exercise-Induced Muscle Damage: A Randomized, Double-Blind, Placebo-Controlled Study
Gurton, W. H., Gough, L. A., Lynn, A., & Ranchordas, M. K. (2025) · Nutrients · doi:10.3390/nu17213383 · Cited by 4 · see citing works
Acute effects of sodium citrate supplementation on competitive performance and lactate level of elite fitness challenge athletes: A crossover, placebo-controlled, double-blind study
Nabilpour, M., Zouita, A., Mayhew, J., Rahimi, G. M. M., Alikhajeh, Y., Taheri, M., Irandoust, K., Youzbashi, L., Granacher, U., & Zouhal, H. (2024) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2024.02.001 · Cited by 3 · see citing works
Greater lactate accumulation does not alter peripheral concentrations of key appetite-regulating neuropeptides
McCarthy, S. F., Bornath, D. P. D., Tucker, J. A. L., Cohen, T. R., Medeiros, P. J., & Hazell, T. J. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00559.2024 · Cited by 4 · see citing works
Effects of sodium bicarbonate on 200 m time trial performance and physiological responses in swimmers: a systematic review and meta-analysis of randomized controlled trials
Huang, D., Wang, X., Takagi, H., Wang, Z., Wang, C., Yang, L., & Huang, B. (2025) · Research in Sports Medicine · doi:10.1080/15438627.2025.2456630 · Cited by 2 · see citing works
The effect of infrared radiation-emitting garments on the acute skeletal muscle molecular signalling responses to high-intensity interval exercise
Bond, J. W., Harrison, P. T., Dugdale, H. F., Martin, N. R. W., Bailey, S. J., Brownstone, T., & Ferguson, R. A. (2026) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00258.2026
The adaptive response of humans to exercise: Impact of exercise intensity, fibre-type specific responses and molecular patterns of response
Scribbans, T. D. (2016) · QSpace (Queen's University Library)
The effectiveness of sodium bicarbonate as an ergogenic aid in normoxia and hypoxia : the importance of ingestion dose and timing
Gough, L. A. (2018)
ERGOGENIC AIDS IN COMPETITIVE HANDBALL PLAYERS: A NARRATIVE REVIEW
Muñoz, A., Sánchez-Oliver, A. J., Rivilla-García, J., López‐Samanes, Á., & Coso, J. D. (2022) · Journal of Sport and Health Research · doi:10.58727/jshr.92827
Investigating the Effect of Foot Reflexology Massage on Post-electroconvulsive Therapy Headache
Zareei, A., Fallahi‐Khoshknab, M., Vahedi, M., Farahani, Z. B., & Rahgoi, A. (2023) · Complementary Medicine Journal · doi:10.61186/cmja.12.4.33
Common questions and misconceptions of sodium bicarbonate as an ergogenic aid: what does the science really show?
Antonio, B. B., Shannon, E. S., Candow, D. G., Gough, L. A., Grgić, J., Gurton, W. H., McNaughton, L. R., Roberts, J., Saunders, B., Schwarz, A. V., et al. (2026) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2026.2724103

Metabolic Acidosis Reduces Exercise-induced Up-regulation Of PGC-1alpha mRNA
Bishop, D. J., Edge, J., Mündel, T., Hawk, E., Leikis, M. J., & Pilegaard, H. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000321589.97446.a8 · Cited by 1 · see citing works
Ammonium Chloride Ingestion Attenuates Exercise-Induced mRNA Levels in Human Muscle
Edge, J., Mündel, T., Pilegaard, H., Hawke, E. J., Leikis, M. J., Lopez-Villalobos, N., Oliveira, R. S. F., & Bishop, D. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141317 · Cited by 20 · see citing works
The effect of pre-exercise alkalosis on lactate/pH regulation and mitochondrial respiration following sprint-interval exercise in humans
Thomas, C., Delfour‐Peyrethon, R., Lambert, K., Granata, C., Hobbs, T., Hanon, C., & Bishop, D. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1073407 · Cited by 11 · see citing works
Effect of sodium bicarbonate on muscle metabolism during intense endurance cycling
Stephens, T. J., McKenna, M. J., Canny, B. J., Snow, R. J., & McConell, G. K. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200204000-00009 · Cited by 115 · see citing works
EFFECT OF SODIUM BICARBONATE INGESTION ON MUSCLE METABOLISM AND PERFORMANCE DURING INTENSE ENDURANCE EXERCISE
McConell, G. K., Stephens, T., Snow, R. J., & Canny, B. J. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805001-01518

Authors: Percival, M. E., Martin, B. J., Gillen, J. B., Skelly, L. E., MacInnis, M. J., Green, A. E., Tarnopolsky, M. A., & Gibala, M. J.
Affiliations: McMaster University (CA)
Corresponding author: Gibala, Martin J.
ORCID: Martin, Brian J.
Gillen, Jenna B.
Skelly, Lauren E.
MacInnis, Martin J.
Green, Alex E.
Tarnopolsky, Mark A.
Gibala, Martin J.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2015-12-01
Volume: 119
Issue: 11
Pages: 1303-1312
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00048.2015
PMC: PMC4669344
OpenAlex: W797190648
Cited by: 50
References: 71
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 5
FWCI: 2.67
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Applied Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
MacSphere (McMaster University) (submittedVersion)
MacSphere (McMaster University)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: sodium bicarbonate ingestion, PGC-1α, mitochondrial biogenesis, high-intensity interval training, skeletal muscle, post-exercise recovery, muscle glycogen utilization, blood lactate, AMPK, p38 MAPK, bicarbonate buffering, exercise adaptation
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adult, Bicarbonates, Double-Blind Method, Glycogen, Heart Rate, Humans, Male, Mitochondria, Muscle, Phosphorylation, RNA, Messenger, Transcription Factors, Exercise, Sodium Bicarbonate, Muscle, Skeletal, Cross-Over Studies, p38 Mitogen-Activated Protein Kinases, Young Adult

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Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle

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