CoChat
Sign Up
Cited by 67Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionVisual perception and processing mechanisms

Feedforward inhibitory connections from multiple thalamic cells to multiple regular-spiking cells in layer 4 of the somatosensory cortex

Inoue, Tsuyoshi, Imoto, Keiji·2006·Journal of Neurophysiology
DOI 10.1152/jn.00301.2006
Open this paper in CoChat — free account

Abstract

Thalamocortical (TC) cells in the ventrobasal thalamus make direct excitatory connections with regular-spiking (RS) cells in layer 4 of the somatosensory cortex, but also make disynaptic feedforward inhibitory connections with the RS cells by layer 4 fast-spiking (FS) cells. In this study, we investigated connection rules of the feedforward inhibitory circuit from multiple TC cells to multiple RS cells, at the level of synaptic potentials. Using thalamocortical brain slices of young mice (postnatal days 12-16), we made simultaneous patch-clamp recordings from three adjacent cortical cells (two RS cells and one FS cell), combined with minimal stimulation of presumed single TC fibers. We found that nearly all (97%) of TC fibers, which generated excitatory inputs onto RS cells, also generated divergent excitatory inputs onto adjacent FS cells. Some 44% of TC fibers generated divergent excitatory inputs onto adjacent pairs of RS cells. We then combined the triple patch-clamp recording with multisite (two to three) minimal stimulation of single TC fibers and found that 86% of FS cells received convergent inputs from all of the stimulated TC fibers. We also found that 68% of FS cells generated divergent inhibitory inputs onto adjacent pairs of RS cells. The results indicate that spikes in TC cells, which excite RS cells, also excite adjacent FS cells with high fidelity. The results also indicate that FS cells receive convergent excitatory inputs from multiple TC cells and then send…

Integrity signals

Registry

Crossref · 10.1152/jn.00301.2006

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Unitary thalamocortical connections onto PV cells are faster and about fourfold stronger than those onto pyramidal cells.

    “Unitary thalamocortical connections onto PV cells are faster and fourfold stronger than those onto the PCs(Cruikshank et al., 2007; Gabernet et al., 2005; Inoue and Imoto, 2006)”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Inoue and Imoto, 2006

  • Thalamocortical axons synapse onto both pyramidal cells and neighboring PV cells, but have a higher connection probability onto PV interneurons through greater convergence and divergence.

    “TC axons synapse onto both PCs and neighboring PV cells (Cruikshank et al., 2007; Gabernet et al., 2005; Inoue and Imoto, 2006), but show higher connection probability onto PV INs through larger convergence and divergence (Bruno and Simons, 2002; Cruikshank et al., 2007; Inoue and Imoto, 2006; Swadlow and Gusev, 2002).”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Inoue and Imoto, 2006

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Inoue, T., & Imoto, K.
Affiliations
National Institute for Physiological Sciences (JP)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2006-10
Volume
96
Issue
4
Pages
1746-1754
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00301.2006
OpenAlex
W1982143985
Cited by
67
References
38
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 2
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
ventrobasal thalamus, feedforward inhibition, fast-spiking interneurons, synaptic connectivity, thalamocortical circuits
MeSH terms
Action Potentials, Animals, Cell Communication, Electrophysiology, Mice, Inbred C57BL, Neural Inhibition, Synaptic Transmission, Somatosensory Cortex, Synapses, Thalamus, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review