Numerical data on neocortical neurons in adult rat, with special reference to the GABA population

Beaulieu, Clermont

doi:10.1016/0006-8993(93)90884-p

Cited by 301Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsNeural dynamics and brain function

Numerical data on neocortical neurons in adult rat, with special reference to the GABA population

Beaulieu, Clermont·1993·Brain Research

DOI 10.1016/0006-8993(93)90884-p

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Abstract

The disector method was used to estimate the numerical density of neurons (number per unit volume) and their actual number per column (number under a given area of pial surface), in the occipital (monocular segment of the primary visual area, Oc1M), the parietal (somatosensory barrelfield area, Par1) and the frontal cortex (primary motor area, Fr1) of adult rat. Values were first obtained for all neurons in each layer, and then for GABA neurons as identified with postembedding immunocytochemistry on semithin sections. The numerical density of neurons in the frontal cortex (34,000/mm3) was significantly lower than in the two other neocortical areas (occipital: 52,000; parietal: 48,000/mm3). The GABA population showed a similar difference and consequently represented an equivalent proportion of total (15%) in the three cortical areas. Across layers, there was an alternate distribution of low and high density of neurons from layers II-III to VI in the three cortical areas, with the highest density in layer IV of the two sensory areas. The laminar changes in density of the GABA neurons were not as pronounced as those of the overall population. Consequently, the layers with the highest overall neuronal densities tended to have a lower proportion of GABA neurons and vice versa. There were more neurons under 1 mm2 of surface in the parietal (90,000) than the occipital or the frontal cortex (71,000), which was also true of the GABA neurons. The greater number of neurons per column in the parietal cortex was mostly imputable to layer IV, the main recipient of thalamic axons.(ABSTRACT TRUNCATED AT 250 WORDS)

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Authors: Beaulieu, C.
Affiliations: Université de Montréal (CA)
Corresponding author: Beaulieu, Clermont
Venue: Brain Research
Publisher: Elsevier BV
Published: 1993-04
Volume: 609
Issue: 1-2
Pages: 284-292
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(93)90884-p
OpenAlex: W1995194777
Cited by: 301
References: 41
Citations by year: 2026: 5 · 2025: 7 · 2024: 15 · 2023: 10 · 2022: 4 · 2021: 13 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 16 · 2016: 7 · 2015: 15 · 2014: 9 · 2013: 19 · 2012: 6
FWCI: 2.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: neocortical neurons, GABAergic neurons, neuronal density, cortical layers, primary visual cortex, primary motor cortex, layer 4, rat cortex
MeSH terms: Animals, Cerebral Cortex, gamma-Aminobutyric Acid, Immunohistochemistry, Male, Motor Cortex, Neurons, Somatosensory Cortex, Visual Cortex, Tissue Embedding, Rats

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Numerical data on neocortical neurons in adult rat, with special reference to the GABA population

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