Cited by 49Ion channel regulation and functionNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

The calcium-binding protein parvalbumin modulates the firing 1 properties of the reticular thalamic nucleus bursting neurons

Albéri, Lavinia, Lintas, Alessandra, Kretz, Robert, Schwaller, Beat, Villa, Alessandro E. P.·2013·Journal of Neurophysiology

Abstract

The reticular thalamic nucleus (RTN) of the mouse is characterized by an overwhelming majority of GABAergic neurons receiving afferences from both the thalamus and the cerebral cortex and sending projections mainly on thalamocortical neurons. The RTN neurons express high levels of the “slow Ca 2+ buffer” parvalbumin (PV) and are characterized by low-threshold Ca 2+ currents, I T . We performed extracellular recordings in ketamine/xylazine anesthetized mice in the rostromedial portion of the RTN. In the RTN of wild-type and PV knockout (PVKO) mice we distinguished four types of neurons characterized on the basis of their firing pattern: irregular firing (type I), medium bursting (type II), long bursting (type III), and tonically firing (type IV). Compared with wild-type mice, we observed in the PVKOs the medium bursting (type II) more frequently than the long bursting type and longer interspike intervals within the burst without affecting the number of spikes. This suggests that PV may affect the firing properties of RTN neurons via a mechanism associated with the kinetics of burst discharges. Ca v 3.2 channels, which mediate the I T currents, were more localized to the somatic plasma membrane of RTN neurons in PVKO mice, whereas Ca v 3.3 expression was similar in both genotypes. The immunoelectron microscopy analysis showed that Ca v 3.2 channels were localized at active axosomatic synapses, thus suggesting that the differential localization of Ca v 3.2 in the PVKOs may affect bursting dynamics. Cross-correlation analysis of simultaneously recorded neurons from the same electrode tip showed that about one-third of the cell pairs tended to fire synchronously in both genotypes, independent of PV expression. In summary, PV deficiency does not affect the functional connectivity between RTN neurons but affects the distribution of Ca v 3.2 channels and the dynamics of burst discharges of RTN cells, which in turn regulate the activity in the thalamocortical circuit.

Integrity signals

Registry

Crossref · 10.1152/jn.00375.2012

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Albéri, L., Lintas, A., Kretz, R., Schwaller, B., & Villa, A. E. P.
Affiliations
  • Unit of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland; and
  • University of Fribourg (CH)
  • University of Lausanne (CH)
Corresponding author
Villa, Alessandro E. P.
Venue
Journal of Neurophysiology
Published
2013-06-01
Volume
109
Issue
11
Pages
2827-2841
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
OpenAlex
W2084755356
Cited by
49
References
105
Citations by year
2026: 3 · 2025: 4 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 2
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
  • reroDoc Digital Library (submittedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
  • Universität Heidelberg
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
parvalbumin, thalamic reticular nucleus, bursting neurons, low-threshold calcium current, calcium buffering, neuronal firing patterns, axosomatic synapses, neuronal synchronization, thalamocortical circuits, GABAergic neurons
MeSH terms
Action Potentials, Animals, Axons, Calcium, Genotype, Mice, Inbred C57BL, Neurons, Parvalbumins, Synapses, Intralaminar Thalamic Nuclei, Calcium Channels, T-Type, Protein Transport, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review