Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex
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Inhibitory interneurons in the cerebral cortex include a vast array of subtypes, varying in their molecular signatures, electrophysiological properties, and connectivity patterns. This diversity suggests that individual inhibitory classes have unique roles in cortical circuits; however, their characterization to date has been limited to broad classifications including many subtypes. We used the Cre/LoxP system, specifically labeling parvalbumin(PV)-expressing interneurons in visual cortex of PV-Cre mice with red fluorescent protein (RFP), followed by targeted loose-patch recordings and two-photon imaging of calcium responses in vivo to characterize the visual receptive field properties of these cells. Despite their relative molecular and morphological homogeneity, we find that PV+ neurons have a diversity of feature-specific visual responses that include sharp orientation and direction-selectivity, small receptive fields, and band-pass spatial frequency tuning. These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties.
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A few interneurons within a molecularly defined group show strong stimulus selectivity similar to that of pyramidal neurons.
“a few INs within a molecularly defined group show strong stimulus selectivity that is similar to that of pyramidal neurons (Ma et al., 2010; Runyan et al., 2010).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Runyan et al., 2010
A subset of PV interneurons in superficial layers of mouse V1 responds highly selectively to visual orientation.
“a subset of PV INs in superficial layers of mouse V1 responds highly selectively to visual orientation (Runyan et al., 2010).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Runyan et al., 2010
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- Authors
- Runyan, C. A., Schummers, J., Van Wart, A., Kuhlman, S. J., Wilson, N. R., Huang, Z. J., & Sur, M.
- Affiliations
- Massachusetts Institute of Technology (US)
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Sur, Mriganka
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 67
- Issue
- 5
- Pages
- 847-857
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2948796
- OpenAlex
- W2046426203
- Cited by
- 244
- References
- 70
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 21 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 12 · 2019: 10 · 2018: 16 · 2017: 13 · 2016: 18 · 2015: 16 · 2014: 20 · 2013: 26 · 2012: 28
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Figshare (submittedVersion, cc-by)
- Elsevier eBooks
- KiltHub Repository
- Funders
- National Institutes of Health (1f32ey018065-01a2)
- U.S. Public Health Service (F31N067951)
- National Institute of Mental Health (T32MH074249)
- National Eye Institute (R01EY018648, F32 EY018065, T32EY013935, R01EY007023)
- National Institute of Neurological Disorders and Stroke (R01NS052784, F31NS067951)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- parvalbumin interneurons, inhibitory interneurons, visual cortex, orientation selectivity, direction selectivity, receptive fields, spatial frequency tuning, perisomatic inhibition, cortical circuits, calcium imaging
- MeSH terms
- Red Fluorescent Protein, Animals, Biophysics, Calcium, Electric Stimulation, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Interneurons, Luminescent Proteins, Membrane Potentials, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Parvalbumins, Photic Stimulation, Visual Cortex, Visual Pathways, Photons, Patch-Clamp Techniques, Green Fluorescent Proteins, Mice
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