The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat.
Abstract
Previous work has shown that voluntary running increases cell proliferation and neurogenesis in the dentate gyrus of the adult hippocampus. Here we report that long-term running for 24 days results in a down-regulation of hippocampal progenitor proliferation to one-half the level of nonrunning controls compared with a fivefold increase in progenitor proliferation seen after 9 days of voluntary running (short-term running). The negative effects seen on proliferation after 24 days of running were prevented by restricting daily running distances (by 30-50%) during 24 days. Long-term running for 24 days increases the response of the hypothalamic-pituitary-adrenal axis, with an increase in adrenal gland weight and increased plasma corticosterone levels, as well as decreased thymus weight, indicating a stress response as a possible mediator of decreased progenitor proliferation. Furthermore, the negative effects seen on the observed stress response after 24 days of running were prevented by restricting daily running distance. Short-term running did not alter these stress parameters compared with nonrunning controls. However, it increased phosphorylated cyclic AMP response element binding protein (pCREB) in the dentate gyrus, an increase that was not seen in nonrunning controls or after 24 days of running. Taken together, these data suggest that voluntary running does not always enhance proliferation and that the decrease in progenitor proliferation seen in long-term running is possibly mediated by mechanisms involving a stress response in the animal. However, a moderate level of long-term running was able to prevent the negative stress-related changes seen in unrestricted long-term running.
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“Using hippocampus dependent paradigms, AE has been reliably demonstrated to improve task performance in animal models (van Praag, 2009; Voss et al., 2013a), although this does also depend on others aspects of AE such as the duration and intensity of AE (Naylor et al., 2005; Ploughman et al., 2007; O’Callaghan et al., 2009).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Naylor et al., 2005
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Cites
Neurogenesis in the adult human hippocampus
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Self-citationRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
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Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
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Running enhances neurogenesis, learning, and long-term potentiation in mice
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Learning enhances adult neurogenesis in the hippocampal formation
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Hippocampal atrophy in recurrent major depression
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The stressed hippocampus, synaptic plasticity and lost memories
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Mirescu, C., & Gould, E. (2006) · Hippocampus · doi:10.1002/hipo.20155 · Cited by 701
Olson, A. K., Eadie, B. D., Ernst, C., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20157 · Cited by 592
Social isolation delays the positive effects of running on adult neurogenesis
Stranahan, A. M., Khalil, D., & Gould, E. (2006) · Nature Neuroscience · doi:10.1038/nn1668 · Cited by 467
Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., Oomen, C. A., & Czéh, B. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.08.003 · Cited by 449
Self-citationGarland, T., Schutz, H., Chappell, M. A., Keeney, B. K., Meek, T. H., Copes, L. E., Acosta, W., Drenowatz, C., Maciel, R. C., van Dijk, G., et al. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048397 · Cited by 444
Metadata
- Authors
- Naylor, A. S., Persson, A. I., Eriksson, P. S., Jonsdottir, I. H., & Thorlin, T.
- Affiliations
- University of Gothenburg (SE)
- ORCID
- Persson, Anders I.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2005-05
- Volume
- 93
- Issue
- 5
- Pages
- 2406-2414
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2054113947
- Cited by
- 127
- References
- 50
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2019: 1 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 12 · 2012: 6
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- voluntary running, adult neurogenesis, dentate gyrus, spontaneously hypertensive rats, hypothalamic-pituitary-adrenal axis, corticosterone, stress response, thymus, CREB phosphorylation, exercise duration
- MeSH terms
- Adrenal Glands, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Bromodeoxyuridine, Cell Count, Corticosterone, Female, Hippocampus, Immunohistochemistry, Inhibition, Psychological, Phosphorylation, Physical Conditioning, Animal, Random Allocation, Rats, Inbred SHR, Running, Stem Cells, Thymus Gland, Time Factors, Cyclic AMP Response Element-Binding Protein, Cell Proliferation, Rats
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