Social isolation delays the positive effects of running on adult neurogenesis
Open accessAbstract
Social isolation can exacerbate the negative consequences of stress and increase the risk of developing psychopathology. However, the influence of living alone on experiences generally considered to be beneficial to the brain, such as physical exercise, remains unknown. We report here that individual housing precludes the positive influence of short-term running on adult neurogenesis in the hippocampus of rats and, in the presence of additional stress, suppresses the generation of new neurons. Individual housing also influenced corticosterone levels--runners in both housing conditions had elevated corticosterone during the active phase, but individually housed runners had higher levels of this hormone in response to stress. Moreover, lowering corticosterone levels converted the influence of short-term running on neurogenesis in individually housed rats from negative to positive. These results suggest that, in the absence of social interaction, a normally beneficial experience can exert a potentially deleterious influence on the brain.
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Social isolation delays the positive effects of running on adult neurogenesis in rats.
“delays the positive effects of running on adult neurogenesis in rats;15”
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Bustamante, E. E., Williams, C. F., & Davis, C. L. (2016) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2016.02.004 · Cited by 32 · see citing works
Li, A., Yau, S.-Y., Machado, S., Wang, P., Yuan, T.-F., & So, K.-F. (2019) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527318666190308102804 · Cited by 27 · see citing works
- Authors
- Stranahan, A. M., Khalil, D., & Gould, E.
- Affiliations
- Princeton University (US)
- Corresponding author
- Gould, Elizabeth
- Venue
- Nature Neuroscience
- Published
- 2006-03-12
- Volume
- 9
- Issue
- 4
- Pages
- 526-533
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3029943
- OpenAlex
- W2147162709
- Cited by
- 467
- References
- 49
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 12 · 2020: 17 · 2019: 19 · 2018: 15 · 2017: 21 · 2016: 34 · 2015: 31 · 2014: 34 · 2013: 30 · 2012: 31
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (F31AG024690)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- social isolation, adult neurogenesis, running, hippocampus, corticosterone, stress, individual housing, social interaction, physical activity, rats
- MeSH terms
- Adrenalectomy, Animals, Anti-Inflammatory Agents, Corticosterone, Hippocampus, Housing, Animal, Male, Neurons, Running, Social Isolation, Stress, Psychological, Time Factors, Rats, Sprague-Dawley, Cell Proliferation, Rats
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