Cited by 128Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

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Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat.

Naylor, Andrew S., Persson, Anders I., Eriksson, Peter S., Jonsdottir, Ingibjörg H., Thorlin, Thorleif·2005·Journal of Neurophysiology

DOI 10.1152/jn.01085.2004

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Abstract

Previous work has shown that voluntary running increases cell proliferation and neurogenesis in the dentate gyrus of the adult hippocampus. Here we report that long-term running for 24 days results in a down-regulation of hippocampal progenitor proliferation to one-half the level of nonrunning controls compared with a fivefold increase in progenitor proliferation seen after 9 days of voluntary running (short-term running). The negative effects seen on proliferation after 24 days of running were prevented by restricting daily running distances (by 30-50%) during 24 days. Long-term running for 24 days increases the response of the hypothalamic-pituitary-adrenal axis, with an increase in adrenal gland weight and increased plasma corticosterone levels, as well as decreased thymus weight, indicating a stress response as a possible mediator of decreased progenitor proliferation. Furthermore, the negative effects seen on the observed stress response after 24 days of running were prevented by restricting daily running distance. Short-term running did not alter these stress parameters compared with nonrunning controls. However, it increased phosphorylated cyclic AMP response element binding protein (pCREB) in the dentate gyrus, an increase that was not seen in nonrunning controls or after 24 days of running. Taken together, these data suggest that voluntary running does not always enhance proliferation and that the decrease in progenitor proliferation seen in long-term running is possibly mediated by mechanisms involving a stress response in the animal. However, a moderate level of long-term running was able to prevent the negative stress-related changes seen in unrestricted long-term running.

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Authors: Naylor, A. S., Persson, A. I., Eriksson, P. S., Jonsdottir, I. H., & Thorlin, T.
Affiliations: University of Gothenburg (SE)
ORCID: Persson, Anders I.
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 2005-05
Volume: 93
Issue: 5
Pages: 2406-2414
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.01085.2004
OpenAlex: W2054113947
Cited by: 127
References: 50
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2019: 1 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 12 · 2012: 6
FWCI: 1.60
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: voluntary running, adult neurogenesis, dentate gyrus, spontaneously hypertensive rats, hypothalamic-pituitary-adrenal axis, corticosterone, stress response, thymus, CREB phosphorylation, exercise duration
MeSH terms: Adrenal Glands, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Bromodeoxyuridine, Cell Count, Corticosterone, Female, Hippocampus, Immunohistochemistry, Inhibition, Psychological, Phosphorylation, Physical Conditioning, Animal, Random Allocation, Rats, Inbred SHR, Running, Stem Cells, Thymus Gland, Time Factors, Cyclic AMP Response Element-Binding Protein, Cell Proliferation, Rats

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Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat.

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