Urge to scratch represented in the human cerebral cortex during itch
Abstract
1. We used functional positron emission tomography (PET), measuring regional cerebral blood flow (rCBF) as an index of neuronal activity, to investigate the central processing of itch in 10 healthy volunteers subjected to intracutaneous injections of histamine. 2. The study has unraveled a central representation that depicts a motor intention of the urge to scratch contingent on the perception of unpleasant itch. The coactivation of the anterior cingulate cortex (ACC), supplementary motor area (SMA), premotor area (PM), and inferior parietal lobule (IPL) substantiates that the posterior sector of the ACC (Brodmann 24) is related to the sensorial/affectional aspect of the event. The premotor cortical areas (SMA, PM) and the IPL may participate in the preparation of an intended action.
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The activity in SMA and pre-SMA during threat to the owned rubber hand reflects an urge to withdraw the hand rather than anxiety.
“Thus, we suggest that the activity in SMA and pre-SMA in the present study reflects an urge to withdraw the hand, rather than anxiety, because this activity was not correlated with the anxiety ratings.”
From Threatening a rubber hand that you feel is yours elicits a cortical anxiety response. (2007) · cites this paper as [29]
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BackgroundResultInfluentialSelf-citationSpinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch
Andrew, D., & Craig, A. D. (2001) · Nature Neuroscience · doi:10.1038/82924 · Cited by 568 · see citing works
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Self-citationCerebral processing of acute skin and muscle pain in humans.
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“The reason for this reduction but is activated by various attention and motor tasks not in rCBF is not known, but similar observations have been related to pain (Hsieh et al. 1994, 1995; Paus et al. 1993; presented in other PET pain studies (Derbyshire et al. 1994; Stephan et al. 1995).”
BackgroundDrzezga, A. E., Darsow, U. G., Treede, R., Siebner, H. R., Frisch, M., Munz, F., Weilke, F., Ring, J., Schwaiger, M., & Bartenstein, P. (2001) · Pain · doi:10.1016/s0304-3959(01)00271-8 · Cited by 255 · see citing works
“Consistent with a previous study (Hsieh et al., 1994), we did not detect any activation in the thalamic nuclei following histamine application, either by subtraction or by correlation analysis (up to a signi®cance level of P 0:1).”
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Porro, C. A., Cettolo, V., Francescato, M. P., & Baraldi, P. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3312 · Cited by 253 · see citing works
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“Imaging studies in humans have shown that the anterior cingulate cortex is activated by noxious stimuli and is a critical site for the affective-motivational aspects of thermal pain and other adverse sensations (Hsieh et al., 1994; Craig et al., 1996; Rainville et al., 1997).”
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Mochizuki, H., Tashiro, M., Kano, M., Sakurada, Y., Itoh, M., & Yanai, K. (2003) · Pain · doi:10.1016/s0304-3959(03)00249-5 · Cited by 211 · see citing works
“Both sensory signals are conveyed to the brain via C-fibers and spinothalamic tracts, and activate the same brain regions such as the frontal, parietal and cingulate cortex (Schmelz, 2001; Hsieh et al., 1994).”
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“While brain processing of histamine-induced itch has been investigated in several studies (Hsieh et al, 1994; Darsow et al, 2000; Drzezga et al, 2001; Mochizuki et al, 2003, 2009; Leknes et al, 2007; Schneider et al, 2008; Valet et al, 2008; Vierow et al, 2009; Pfab et al, 2010) no studies have yet…”
Tickling Expectations: Neural Processing in Anticipation of a Sensory Stimulus
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“This right-hemispheric dominance in activation may either be interpreted in terms of it being part of an attentional network or as lateralized processing of somatospatial information (Coull, 1998; Vallar, 1997; Kolb & Whishaw, 1996; Hsieh et al., 1994).”
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“…and neuroimaging studies identified a network comprised of the ACC, parietal operculum, thalamus and the insula as the origin of unpleasant sensations associated with itching and the urge to scratch, or pain (Hsieh et al., 1994; Kwan et al., 2000; Derbyshire et al., 2004; Bohlhalter et al., 2006).”
BackgroundBrain processing of capsaicin-induced secondary hyperalgesia
Baron, R., Baron, Y., Disbrow, E. A., & Roberts, T. P. L. (1999) · Neurology · doi:10.1212/wnl.53.3.548 · Cited by 186 · see citing works
Right-lateralised central processing for pain of nitroglycer-induced cluster headache
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“The interpretation is substantiatedby the evidencethat acute itch activated the ipsilateralSMA and the contralateral BA24 whileacutepain activatedcontralaterallyboth the SMA and BA24(Coghillet al. 1994;Hsieh 1995;Hsieh et al. 1994;Hsiehet al. 1995b;Hsiehet al. 1995d).”
Self-citationIshiuji, Y., Coghill, R. C., Patel, T. S., Oshiro, Y., Kraft, R., & Yosipovitch, G. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09308.x · Cited by 176 · see citing works
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Central circuit mechanisms of itch
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A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy
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“In addition, movement intention/preparation may increase the activity in the motor cortex (Hsieh et al., 1994; Deiber et al., 1996).”
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“It has been found that similar areas of the brain, including the premotor areas, are involved in both sensations.(55,56) Itch is also recognized as a symptom of neuropathic pain and is measured as one component of the neuropathic pain scale.”
BackgroundPeyron, R., Garcı́a-Larrea, L., Grégoire, M., Convers, P., Richard‐Mornas, A., Lavenne, F., Barral, F.-G., Mauguı̀ere, F., Michel, D., & Laurent, B. (2000) · Pain · doi:10.1016/s0304-3959(99)00190-6 · Cited by 162 · see citing works
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“In PET studies induction of itch by histamine application co-activated the anterior cingulate and insular cortex, premotor and supplementary motor area, cerebellum, primary somatosensory cortex and thalamus (Hsieh et al., 1994; Drzezga et al., 2001; Mochizuki et al., 2003).”
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“The same area has also been reported to be involved in the perception of itch (Hsieh et al. 1994), and it is conceivable that the frontal activation reported by Di Piero et al. (1994) also corresponds to this region.”
BackgroundDarsow, U. G., Drzezga, A. E., Frisch, M., Munz, F., Weilke, F., Bartenstein, P., Schwaiger, M., & Ring, J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00193.x · Cited by 156 · see citing works
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Garcı́a-Larrea, L. (2012) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2012.06.001 · Cited by 154 · see citing works
“Studies in which these regions were not activated by itching (e.g. Hsieh et al 1994, Darsow et al 2000, Mochizuki et al 2003) to determine activated regions, with possible lack of sensitivity to small activation volumes.”
Zusman, M. (2002) · Manual Therapy · doi:10.1054/math.2002.0442 · Cited by 155 · see citing works
“Evidence suggests that complimentary activation of cortical and subcortical motor areas is related to instructions for movements or postures intended to escape painful stimulation (Hsieh et al, 1994; Price 2000).”
BackgroundNeural basis of contagious itch and why some people are more prone to it
Holle, H., Warne, K., Seth, A. K., Critchley, H. D., & Ward, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216160109 · Cited by 145 · see citing works
“The planning of scratching movements is linked to premotor activity, whereas the intention to scratch (or not) is linked to engagement of the prefrontal cortex (12), consistent with this area’s recognized role in willed actions (13).”
BackgroundCutaneous field stimulation (CFS): a new powerful method to combat itch
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“Interestingly, the sensation of itch also involves activation of anterior cingulate cortex [71] and can similarly be inhibited by cold or by noxious stimuli [110].”
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“Several neuroimaging studies of itching also reported that an pruritic stimulus did not activate the thalamus (Drzezga et al., 2001; Darsow et al., 2000; Hsieh et al., 1994).”
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Buddenkotte, J., & Steinhoff, M. S. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.01995.x · Cited by 126 · see citing works
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Kupers, R. C., Gybels, J., & GJEDDE, A. H. (2000) · Pain · doi:10.1016/s0304-3959(00)00295-5 · Cited by 116 · see citing works
“Since the ACC also plays a major role in response selection and inhibition (Devinsky et al., 1995), this may explain the lack of activation of BA 24 0 in chronic pain (but see Hsieh et al., 1994).”
BackgroundLugon, J. R. (2005) · Hemodialysis International · doi:10.1111/j.1492-7535.2005.01130.x · Cited by 115 · see citing works
Schmelz, M. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00167-0 · Cited by 112 · see citing works
“Moreover, the itch sensation is intimately linked to the desire to scratch, which has recently been visualized as an activation of the pre-motor cortical areas in positron emission tomography investigations [24–26].”
Neural correlates of prickle sensation: a percept-related fMRI study
Davis, K. D., Pope, G. E., Crawley, A. P., & Mikulis, D. J. (2002) · Nature Neuroscience · doi:10.1038/nn955 · Cited by 111 · see citing works
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The Brain Processing of Scratching
Yosipovitch, G., Ishiuji, Y., Patel, T. S., Hicks, M. I., Oshiro, Y., Kraft, R., Winnicki, E., & Coghill, R. C. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.3 · Cited by 107 · see citing works
“Neuroimaging studies assessing the central processing of pruritus have presumed activity in the premotor and supplementary motor areas to the behavioral urge of scratching (Hsieh et al., 1994; Darsow et al., 2000; Drzezga et al., 2001; Mochizuki et al., 2003; Walter et al., 2005; Leknes et al., 2007; Valet et al., 200…”
BackgroundInfluentialItch Induced by a Novel Method Leads to Limbic Deactivations— A Functional MRI Study
Herde, L., Forster, C., Strupf, M., & Handwerker, H. O. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00475.2007 · Cited by 106 · see citing works
“Generally, in most of our subjects the ensuing perception of itch was stronger compared with other studies (Drzezga et al. 2001; Hsieh et al. 1994), inciting ratings of TABLE 1.”
InfluentialSchneider, G., Ständer, S., Burgmer, M., Driesch, G., Heuft, G., & Weckesser, M. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.12.003 · Cited by 105 · see citing works
“Previous PET studies (Hsieh et al., 1994; Darsow et al., 2000, 2001; Drzezga et al., 2001; Mochizuki et al., 2003) and fMRI studies (McGlone and Rukwied, 2001; Walter et al.”
BackgroundResultInfluentialNeuronal correlates of gastric pain induced by fundus distension: a 3T‐fMRI study
Lu, C., Wu, Y., Yeh, T.-C., Chen, L., Chang, F. Y., Lee, S., Ho, L. ‐., & Hsieh, J. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00562.x · Cited by 100 · see citing works
Self-citationScratching and noxious heat stimuli inhibit itch in humans: a psychophysical study
Yosipovitch, G., Duque, M. I., Fast, K., Dawn, A. G., & Coghill, R. C. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07711.x · Cited by 102 · see citing works
Valet, M., Pfab, F., Sprenger, T., Wöller, A. A., Zimmer, C., Behrendt, H., Ring, J., Darsow, U. G., & Tölle, T. R. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701002 · Cited by 100 · see citing works
“There are only few neuroimaging studies investigating the patho-/physiological cerebral mechanisms of itch processing (Hsieh et al., 1994; Darsow et al., 2000; Drzezga et al., 2001; Mochizuki et al., 2003; Walter et al., 2005; Leknes et al., 2007).”
BackgroundResultInfluentialTRP channels as novel players in the pathogenesis and therapy of itch
Bı́ró, T., Tóth, B. I., Marincsák, R., Dobrosi, N., Géczy, T., & Paus, R. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.03.002 · Cited by 98 · see citing works
“The various sensory components of itch have been therefore attributed to activation of certain brain areas: the sensory-discriminative component in the primary somatosensory cortex; the motor component of the goal-directed scratching in the premotor and supplementary motor cortex; the affective and motivational compon…”
BackgroundSavin, J. A. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70087-8 · Cited by 97 · see citing works
Weißhaar, E., Kucenic, M., & Fleischer, A. B. (2003) · Acta Dermato Venereologica · doi:10.1080/00015555-0369 · Cited by 99 · see citing works
Pruritus, Personality Traits and Coping in Long-term Follow-up of Burn-injured Patients
Willebrand, M., Low, A., Dyster‐Aas, J., et al. (2004) · Acta Dermato Venereologica · doi:10.1080/00015550410032941 · Cited by 89 · see citing works
“Pruritus can be defined as ‘an unpleasant sensation with the urge to scratch’, and it is represented by mechanisms in the cerebral cortex leading to motor responses to alleviate the problem (1).”
BackgroundPruritus in Burns: Review Article
Goutos, I., Dziewulski, P. G., & Richardson, P. M. (2009) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e318198a2fa · Cited by 88 · see citing works
“This interaction leads to impulse generation to the central nervous system and also to the local release of neuropeptides, including SP.22 Low concentrations of SP can sensitize mast cells and increase tumor necrosis factor- production, which further primes nociceptive nerve terminals.23 The close interaction between…”
BackgroundCell type-specific modulation of sensory and affective components of itch in the periaqueductal gray
Samineni, V. K., Grajales‐Reyes, J. G., Sundaram, S. S., Yoo, J. J., & Gereau, R. W. (2019) · Nature Communications · doi:10.1038/s41467-019-12316-0 · Cited by 87 · see citing works
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Time Course of Activity in Itch-Related Brain Regions: A Combined MEG–fMRI Study
Mochizuki, H., Inui, K., Tanabe, H. C., Akiyama, L. F., Otsuru, N., Yamashiro, K., Sasaki, A. T., Nakata, H., Sadato, N., & Kakigi, R. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00460.2009 · Cited by 85 · see citing works
“Previous studies used histamine to elicit itch (e.g., Drzezga et al. 2001; Hsieh et al. 1994; Leknes et al. 2007; Valet et al. 2008), whereas this study used electrically evoked itch.”
MethodResultEffects of smoking opportunity on cue-elicited urge: A facial coding analysis.
Sayette, M. A., Wertz, J. M., Martin, C. S., Cohn, J. F., Perrott, M. A., & Hobel, J. (2003) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.11.3.218 · Cited by 83 · see citing works
“A positron emission tomography study (Hsieh et al., 1994) offers data consistent with this position.”
Neural basis of reward and craving - a homeostatic point of view
Paulus, M. P. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.4/mpaulus · Cited by 79 · see citing works
“First, in a functional positron emission tomography (PET) study to investigate the neural substrates underlying itch and the motor intention of the urge to scratch, investigators found activation of the anterior cingulate cortex, supplementary motor area, premotor area, and inferior parietal lobule.(55) Others have ob…”
BackgroundThe cerebral representation of scratching-induced pleasantness
Mochizuki, H., Tanaka, S., Morita, T., Wasaka, T., Sadato, N., & Kakigi, R. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00374.2013 · Cited by 81 · see citing works
“…observed in this study were similar to those observed in previous itch studies using PET and fMRI (Darsow et al. 2000; Drzezga et al. 2001; Herde et al. 2007; Hsieh et al. 1994; Ishiuji et al. 2009; Leknes et al. 2007; Mochizuki et al. 2003, 2007, 2009; Papoiu et al. 2011; Walter et al. 2005).”
ResultNeuroanatomy and neurophysiology of itch
Wallengren, J. (2005) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2005.00041.x · Cited by 79 · see citing works
“The C-type primary afferent fibers that conduct itch are not only sensitive to neurotransmitters but also to histamine and to other inflammatory mediators (13).”
BackgroundNeurofilament and calcium-binding proteins in the human cingulate cortex
Nimchinsky, E. A., Vogt, B. A., Morrison, J. H., & Hof, P. R. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970811)384:4 · Cited by 78 · see citing works
Primer of Postoperative Pruritus for Anesthesiologists
Waxler, B., Dadabhoy, Z. P., Stojiljković, L., Rabito, S. F., & Warltier, D. C. (2005) · Anesthesiology · doi:10.1097/00000542-200507000-00025 · Cited by 77 · see citing works
Mediators of Pruritus in Psoriasis
Reich, A., & Szepietowski, J. C. (2007) · Mediators of Inflammation · doi:10.1155/2007/64727 · Cited by 76 · see citing works
Facets and mechanisms of adaptive pain behavior: predictive regulation and action
Morrison, I., Perini, I., & Dunham, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00755 · Cited by 74 · see citing works
“But unlike posterior insula, intracranial microstimulation of human ACC does not result in pain sensations, but in reported feelings of urgency (Bancaud et al., 1976; Hsieh et al., 1994).”
BackgroundHorga, G., Kaur, T., & Peterson, B. S. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12185 · Cited by 74 · see citing works
“, 1991), and in studies of induced itch in which participants are not allowed to scratch (Hsieh et al., 1994).”
BackgroundCerebral Representation of the Relief of Itch by Scratching
Vierow, V., Fukuoka, M., Ikoma, A., Dörfler, A., Handwerker, H. O., & Forster, C. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00207.2009 · Cited by 68 · see citing works
Pfab, F., Valet, M., Sprenger, T., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02163.x · Cited by 68 · see citing works
The functional anatomy of lamina I and its role in post-stroke central pain
Craig, A. D. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)29010-9 · Cited by 66 · see citing works
Pruritus in systemic disease: mechanisms and management
Etter, L., & Myers, S. A. (2002) · Dermatologic Clinics · doi:10.1016/s0733-8635(02)00011-6 · Cited by 67 · see citing works
“Recent research using positron emission tomography (PET) suggests that histamine-induced itch activates both the anterior cingulate cortex, which processes the sensorial and emotional aspects of itch, and the supplemental motor area, which is thought to participate in the preparation of scratching behavior [6].”
BackgroundWhat Do Brain Data Really Show?
Hardcastle, V. G., & Stewart, C. M. (2002) · Philosophy of Science · doi:10.1086/341769 · Cited by 66 · see citing works
“Area 6 appears significantly active after subtraction in studies of phonetic speech processing, voluntary hand and arm movements, sight-reading music, spatial working memory, recognizing facial emotions, binocular disparity, sequence learning, idiopathic dystonia, pain, itch, delayed response alternation, and category…”
BackgroundBrain Activation by Histamine Prick Test-Induced Itch
Walter, B., Sadlo, M., Kupfer, J., et al. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23817.x · Cited by 66 · see citing works
Mochizuki, H., & Kakigi, R. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.11.019 · Cited by 65 · see citing works
“To the best of our knowledge, the cerebral mechanism of itch in humans was first investigated about 20 years ago (Hsieh et al., 1994).”
BackgroundStänder, S., Raap, U., Weißhaar, E., Schmelz, M., Mettang, T., Handwerker, H. O., & Luger, T. A. (2011) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2011.07585.x · Cited by 64 · see citing works
Anatomy and Neurophysiology of Pruritus
Ikoma, A., Cevikbas, F., Kempkes, C., & Steinhoff, M. S. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.04.001 · Cited by 62 · see citing works
Itch Associated with Skin Disease
Yosipovitch, G., & Fleischer, A. B. (2003) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200304090-00004 · Cited by 64 · see citing works
Craig, A. D., Zhang, E.-T., & Blomqvist, A. G. (2002) · Pain · doi:10.1016/s0304-3959(02)00009-x · Cited by 61 · see citing works
“…between the cortical targets of ascending lamina I STT activity and the sites that are activated during pain, temperature and itch sensations in humans (Coghill et al., 1994; Hsieh et al., 1994; Casey et al., 1996; Derbyshire and Jones, 1998; Craig, 2000c; Craig et al., 2000; Drzezga et al., 2001).”
Can itch-related visual stimuli alone provoke a scratch response in healthy individuals?
Lloyd, D. M., Hall, E., Hall, S., & McGlone, F. P. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12132 · Cited by 61 · see citing works
Pathophysiology of itching and sneezing in allergic rhinitis
Pfaar, O., Raap, U., Holz, M., Hoermann, K., & Klimek, L. (2009) · Swiss Medical Weekly · doi:10.4414/smw.2009.12468 · Cited by 63 · see citing works
Recent Advances in Pathophysiology and Current Management of Itch
Greaves, M. W. (2007) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v36n9p788 · Cited by 61 · see citing works
Movement control of manipulative tasks in patients with Gilles de la Tourette syndrome
Serrien, D. J., Nirkko, A. C., Loher, T. J., Lövblad, K., Burgunder, J., & Wiesendanger, M. (2002) · Brain · doi:10.1093/brain/awf024 · Cited by 60 · see citing works
“The latter ®ts in with the observation that secondary motor areas are activated during the urge to scratch (Hsieh et al., 1994).”
BackgroundPsychopathology, depression and dissociative experiences in patients with lichen simplex chronicus
Konuk, N., Koca, R., Atik, L., Muhtar, Ş., Atasoy, N., & Bostancı, B. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.01.006 · Cited by 60 · see citing works
“In patients with no underlying medical or dermatological condition, the scratching may begin unconsciously and evolves into a compulsive ritual, which may cause the lichenification of the skin [7].”
BackgroundMochizuki, H., Schut, C., Nattkemper, L. A., & Yosipovitch, G. (2016) · Allergology International · doi:10.1016/j.alit.2016.08.013 · Cited by 59 · see citing works
Pruritus in Primary Biliary Cirrhosis: Pathogenesis and Therapy
Bergasa, N. V. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.02.013 · Cited by 57 · see citing works
ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation
Lu, Y.-C., Wang, Y.-J., Lu, B., Chen, M., Zheng, P., & Liu, J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3466-17.2018 · Cited by 58 · see citing works
“…et al., 2003; Rushworth et al., 2004; Walton et al., 2004), has been consistently reported to be activated in functional imaging studies of itch (Hsieh et al., 1994; Darsow et al., 2000; Drzezga et al., 2001; Mochizuki et al., 2003; Walter et al., 2005; Leknes et al., 2007), suggesting a…”
BackgroundPruritus and Atopic Dermatitis
Darsow, U. G., Pfab, F., Valet, M., Huss‐Marp, J., Behrendt, H., Ring, J., & Ständer, S. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-010-8230-2 · Cited by 54 · see citing works
“induced itch correlated subjective itch sensation with central activation using positron emission tomography (PET) like in pain studies [24–26].”
MethodAn approach to the treatment of anogenital pruritus
Weichert, G. (2004) · Dermatologic Therapy · doi:10.1111/j.1396-0296.2004.04013.x · Cited by 53 · see citing works
“Histamine-induced itch has been shown to activate central motor areas which are linked to the act of scratching, thereby supporting the observed itch-scratch-itch behavior (2).”
BackgroundPain, temperature, and the sense of the body
Craig, A. D. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9016-8_3 · Cited by 52 · see citing works
Repetitive scratching and noxious heat do not inhibit histamine-induced itch in atopic dermatitis
Ishiuji, Y., Coghill, R. C., Patel, T. S., Dawn, A. G., Fountain, J. M., Oshiro, Y., & Yosipovitch, G. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08281.x · Cited by 51 · see citing works
Jaundice associated pruritis: A review of pathophysiology and treatment
Bassari, R. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i5.1404 · Cited by 50 · see citing works
- Authors
- Hsieh, J. C., Hagermark, O., Stahle-Backdahl, M., Ericson, K., Eriksson, L., Stone-Elander, S., & Ingvar, M.
- Affiliations
- Karolinska Institutet (SE)
- Department of Clinical Neuroscience, Karolinska Institute/Hospital,Stockholm, Sweden.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1994-12-01
- Volume
- 72
- Issue
- 6
- Pages
- 3004-3008
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1902361870
- Cited by
- 237
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- pruritus, anterior cingulate cortex, supplementary motor area, premotor cortex, inferior parietal lobule, regional cerebral blood flow, histamine, action preparation, motor intention
- MeSH terms
- Adult, Cerebral Cortex, Cerebrovascular Circulation, Histamine, Humans, Image Processing, Computer-Assisted, Middle Aged, Pruritus, Tomography, Emission-Computed
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