Responses to Auditory Stimuli in Macaque Lateral Intraparietal Area I. Effects of Training
Abstract
The lateral intraparietal area (LIP) of macaques has been considered unresponsive to auditory stimulation. Recent reports, however, indicate that neurons in this area respond to auditory stimuli in the context of an auditory-saccade task. Is this difference in auditory responsiveness of LIP due to auditory-saccade training? To address this issue, LIP responses in two monkeys were recorded at two different times: before and after auditory-saccade training. Before auditory-saccade training, the animals had never been trained on any auditory task, but had been trained on visual tasks. In both sets of experiments, activity of LIP neurons was recorded while auditory and visual stimuli were presented and the animals were fixating. Before training, 172 LIP neurons were recorded. Among these, the number of cells responding to auditory stimuli did not reach significance, whereas about one-half of the cells responded to visual stimuli. An information theory analysis confirmed that no information about auditory stimulus location was available in LIP neurons in the experiments before training. After training, activity from 160 cells was recorded. These experiments showed that 12% of cells in area LIP responded to auditory stimuli, whereas the proportion of cells responding to visual stimuli remained about the same as before training. The information theory analysis confirmed that, after training, information about auditory stimulus location was available in LIP neurons. Auditory-saccade training therefore generated responsiveness to auditory stimuli de novo in LIP neurons. Thus some LIP cells become active for auditory stimuli in a passive fixation task, once the animals have learned that these stimuli are important for oculomotor behavior.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Learned sensory-motor associations have been shown to correspond to changes in LIP but not MT.
“Learned sensory-motor associations have been shown to correspond to changes in LIP but not MT41, 42.”
From Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area (2008) · cites this paper as [42]
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388 · see citing works
Taussig, M. (1991) · Routledge eBooks · doi:10.4324/9780203397244 · Cited by 2,403 · see citing works
Mountcastle, V. B., Lynch, J. C., Georgopoulos, A., Sakata, H., & Acuna, C. (1975) · Journal of Neurophysiology · doi:10.1152/jn.1975.38.4.871 · Cited by 2,061 · cited 2× · see citing works
“Thus one resolution to the discrepancy between earlier studies that reported no auditory responses in LIP (Hyva¨rinen 1982; Koch and Fuster 1989; Mountcastle et al. 1975) and later studies that did find auditory responses in LIP (Mazzoni et al. 1996a; Stricanne et al. 1996) is that in the former…”
BackgroundResultA Common Network of Functional Areas for Attention and Eye Movements
Corbetta, M., Akbudak, E., Conturo, T. E., Snyder, A. Z., Ollinger, J. M., Drury, H. A., Linenweber, M. R., Petersen, S. E., Raichle, M. E., Essen, D. C. V., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80593-0 · Cited by 1,590 · see citing works
Implantation of magnetic search coils for measurement of eye position: An improved method
Judge, S. J., Richmond, B. J., & Chu, F. C. (1980) · Vision Research · doi:10.1016/0042-6989(80)90128-5 · Cited by 1,545 · see citing works
Andersen, R. A., Snyder, L. H., Bradley, D. C., & Xing, J. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.303 · Cited by 1,486 · see citing works
Self-citationMaunsell, J. H. R., & Essen, D. C. V. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.49.5.1127 · Cited by 1,462 · see citing works
Encoding of Spatial Location by Posterior Parietal Neurons
Andersen, R., Essick, G. K., & Siegel, R. M. (1985) · Science · doi:10.1126/science.4048942 · Cited by 1,413 · see citing works
Self-citationNeuronal correlates of a perceptual decision
Newsome, W. T., Britten, K. H., & Movshon, J. A. (1989) · Nature · doi:10.1038/341052a0 · Cited by 1,177 · see citing works
Coding of intention in the posterior parietal cortex
Snyder, L. H., Batista, A. P., & Andersen, R. A. (1997) · Nature · doi:10.1038/386167a0 · Cited by 1,103 · see citing works
Self-citationCortico-cortical connections in the rhesus monkey
Pandya, D. Ν., & Kuypers, H. G. J. M. (1969) · Brain Research · doi:10.1016/0006-8993(69)90141-3 · Cited by 1,085 · see citing works
The representation of visual salience in monkey parietal cortex
Gottlieb, J. P., Kusunoki, M., & Goldberg, M. E. (1998) · Nature · doi:10.1038/35135 · Cited by 1,078 · see citing works
Andersen, R., Asanuma, C., Essick, G., & Siegel, R. M. (1990) · The Journal of comparative neurology · doi:10.1002/cne.902960106 · Cited by 853 · see citing works
Self-citationMotion perception: seeing and deciding.
Shadlen, M. N., & Newsome, W. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.628 · Cited by 723 · see citing works
Chafee, M. V., & Goldman, P. S. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.6.2919 · Cited by 655 · see citing works
Shared neural control of attentional shifts and eye movements
Kustov, A. A., & Robinson, D. L. (1996) · Nature · doi:10.1038/384074a0 · Cited by 637 · see citing works
Visual, presaccadic, and cognitive activation of single neurons in monkey lateral intraparietal area
Colby, C. L., Duhamel, J. R., & Goldberg, M. E. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.5.2841 · Cited by 631 · see citing works
Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques
Baizer, J. S., Ungerleider, L. G., & Desimone, R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-01-00168.1991 · Cited by 626 · see citing works
Blatt, G. J., Andersen, R. A., & Stoner, G. R. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902990404 · Cited by 611 · see citing works
Self-citationArchitectonic parcellation of the temporal operculum in rhesus monkey and its projection pattern
Pandya, D. Ν., & Sanides, F. (1973) · Anatomy and Embryology · doi:10.1007/bf00523634 · Cited by 553 · see citing works
Receptive-field organization of monkey superior colliculus.
Cynader, M., & Berman, N. E. J. (1972) · Journal of Neurophysiology · doi:10.1152/jn.1972.35.2.187 · Cited by 520 · see citing works
Sparseness of the neuronal representation of stimuli in the primate temporal visual cortex
Rolls, E. T., & Tovée, M. J. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.2.713 · Cited by 500 · see citing works
Functional subdivisions of the temporal lobe neocortex
Baylis, G. C., Rolls, E. T., & Leonard, C. M. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00330.1987 · Cited by 453 · see citing works
Shape selectivity in primate lateral intraparietal cortex
Sereno, A. B., & Maunsell, J. H. R. (1998) · Nature · doi:10.1038/26752 · Cited by 436 · see citing works
Posterior parietal lobe of the primate brain.
Hyvärinen, J. (1982) · Physiological Reviews · doi:10.1152/physrev.1982.62.3.1060 · Cited by 390 · see citing works
Head position signals used by parietal neurons to encode locations of visual stimuli
Brotchie, P., Andersen, R. A., Snyder, L. H., & Goodman, S. J. (1995) · Nature · doi:10.1038/375232a0 · Cited by 382 · see citing works
Self-citationAuditory receptive fields in primate superior colliculus shift with changes in eye position
Jay, M. F., & Sparks, D. L. (1984) · Nature · doi:10.1038/309345a0 · Cited by 341 · see citing works
Coordinate transformations in the representation of spatial information
Andersen, R. A., Snyder, L. H., Li, C.-S. R., & Stricanne, B. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90206-e · Cited by 328 · see citing works
Self-citationAndersen, R. A., Asanuma, C., & Cowan, W. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902320403 · Cited by 313 · see citing works
Self-citationHikosaka, K., Iwai, E., Saito, H., & Tanaka, K. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.5.1615 · Cited by 297 · see citing works
Asanuma, C., Andersen, R. A., & Cowan, W. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410309 · Cited by 294 · see citing works
Self-citationEye-centered, head-centered, and intermediate coding of remembered sound locations in area LIP
Stricanne, B., Andersen, R. A., & Mazzoni, P. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.2071 · Cited by 284 · see citing works
Self-citationRecanzone, G. H., Merzenich, M. M., & Jenkins, W. M. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1057 · Cited by 268 · see citing works
Inferior Parietal Lobule Function in Spatial Perception and Visuomotor Integration
Andersen, R. A. (1987) · Comprehensive physiology · doi:10.1002/cphy.cp010512 · Cited by 263 · see citing works
Self-citationVisual feature selectivity in frontal eye fields induced by experience in mature macaques
Bichot, N. P., Schall, J. D., & Thompson, K. G. (1996) · Nature · doi:10.1038/381697a0 · Cited by 255 · see citing works
Chen, L. L., & Wise, S. P. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.3.1101 · Cited by 250 · see citing works
Functional properties of neurons in the temporo-parietal association cortex of awake monkey
Leinonen, L. M., Hyv�rinen, J., & Sovij�rvi, A. R. A. (1980) · Experimental Brain Research · doi:10.1007/bf00237551 · Cited by 226 · see citing works
Unit study of monkey frontal cortex: active localization of auditory and of visual stimuli
Vaadia, E., Benson, D. A., Hienz, R. D., & Goldstein, M. H. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.4.934 · Cited by 209 · see citing works
Plum, F., & Mountcastle, V. B. (1987) · Medical Entomology and Zoology · Cited by 203 · see citing works
Mazzoni, P., Bracewell, R. M., Barash, S., & Andersen, R. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1439 · Cited by 197 · see citing works
Self-citationResponses of Intraparietal Neurons to Saccadic Targets and Visual Distractors
Platt, M. L., & Glimcher, P. W. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.3.1574 · Cited by 194 · see citing works
Unit activity in monkey parietal cortex related to haptic perception and temporary memory
Koch, K. W., & Fuster, J. M. (1989) · Experimental Brain Research · doi:10.1007/bf00247889 · Cited by 191 · see citing works
Mazzoni, P., Bracewell, R. M., Barash, S., & Andersen, R. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.3.1233 · Cited by 189 · see citing works
Self-citationSnyder, L. H., Batista, A. P., & Andersen, R. A. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.5.2814 · Cited by 151 · see citing works
Self-citationFrontal units of the monkey coding the associative significance of visual and auditory stimuli
Watanabe, M. (1992) · Experimental Brain Research · doi:10.1007/bf00228241 · Cited by 123 · see citing works
Responses to Auditory Stimuli in Macaque Lateral Intraparietal Area II. Behavioral Modulation
Linden, J. F., Grunewald, A., & Andersen, R. A. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.343 · Cited by 116 · see citing works
Self-citationFrontal eye field activity preceding aurally guided saccades
Russo, G. S., & Bruce, C. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.3.1250 · Cited by 113 · see citing works
Chen, L. L., & Wise, S. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03067.1996 · Cited by 112 · see citing works
Motor intention activity in the macaque's lateral intraparietal area. II. Changes of motor plan
Bracewell, R. M., Mazzoni, P., Barash, S., & Andersen, R. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1457 · Cited by 102 · see citing works
Self-citationLocalization of noise bands by Old World monkeys
Brown, C. H., Beecher, M. D., Moody, D. B., et al. (1980) · The Journal of the Acoustical Society of America · doi:10.1121/1.384638 · Cited by 57 · see citing works
Statistical Analysis of the Information Content in the Activity of Cortical Neurons
Gnadt, J., & Breznen, B. (1996) · Vision Research · doi:10.1016/0042-6989(96)00049-1 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Intentional Maps in Posterior Parietal Cortex
Andersen, R. A., & Buneo, C. A. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142922 · Cited by 1,294 · see citing works
Self-citationA common reference frame for movement plans in the posterior parietal cortex
Cohen, Y. E., & Andersen, R. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn873 · Cited by 695 · see citing works
Self-citationNeural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area
Law, C.-T., & Gold, J. I. (2008) · Nature Neuroscience · doi:10.1038/nn2070 · Cited by 516 · see citing works
Thalamus Modulates Consciousness via Layer-Specific Control of Cortex
Redinbaugh, M. J., Phillips, J. M., Kambi, N. A., Mohanta, S., Andryk, S., Dooley, G. L., Afrasiabi, M., Raz, A., & Saalmann, Y. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.005 · Cited by 391 · see citing works
A human parietal face area contains aligned head-centered visual and tactile maps
Sereno, M. I., & Huang, R.-S. (2006) · Nature Neuroscience · doi:10.1038/nn1777 · Cited by 322 · see citing works
Multisensory Space Representations in the Macaque Ventral Intraparietal Area
Schlack, A., Sterbing-D'Angelo, S. J., Hartung, K., Hoffmann, K.-P., & Bremmer, F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0455-05.2005 · Cited by 318 · see citing works
Ben Hamed, S., Duhamel, J.-R., Bremmer, F., & Graf, W. (2001) · Experimental Brain Research · doi:10.1007/s002210100785 · Cited by 242 · see citing works
Rama, P. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh037 · Cited by 110 · see citing works
Genovesio, A., & Ferraina, S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00712.2003 · Cited by 100 · see citing works
Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates
Dai, J., Brooks, D. I., & Sheinberg, D. L. (2014) · Current Biology · doi:10.1016/j.cub.2013.11.011 · Cited by 97 · see citing works
- Authors
- Grunewald, A., Linden, J. F., & Andersen, R. A.
- Affiliations
- Division of Biology and
- California Institute of Technology (US)
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1999-07-01
- Volume
- 82
- Issue
- 1
- Pages
- 330-342
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2199619069
- Cited by
- 129
- References
- 51
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 6
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- lateral intraparietal area, auditory responses, macaque, oculomotor behavior, information theory, visual responses
- MeSH terms
- Acoustic Stimulation, Animals, Conditioning, Psychological, Feedback, Fixation, Ocular, Functional Laterality, Macaca mulatta, Male, Neurons, Oculomotor Muscles, Parietal Lobe, Photic Stimulation, Reaction Time, Saccades, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
