The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis
Abstract
Preeclampsia, a systemic syndrome of pregnancy clinically characterized by new onset of proteinuria and hypertension, is associated with significant morbidity and mortality to both mothers and fetuses. The pathogenesis of preeclampsia has been enigmatic; this review will focus on understanding the origins of this disorder. Preeclampsia originates in the placenta, starting with inadequate cytotrophoblast invasion and ending with widespread maternal endothelial dysfunction. Production of placental anti-angiogenic factors, specifically soluble fms-related tyrosine kinase 1 and soluble endoglin, have been shown to be upregulated in preeclampsia. These placental anti-angiogenic factors are released into the maternal circulation; their actions disrupt the maternal endothelium and result in hypertension, proteinuria, and the other systemic manifestations of preeclampsia. The molecular basis for placental dysregulation of these pathogenic factors remains unknown, remains unknown. Hypoxia is likely an important regulator. Other factors such as alterations in the renin-angiotensin-aldosterone axis, immune maladaption, excessive shedding of trophoblast debris, oxidative stress, and genetic factors likely contribute to the pathogenesis of the abnormal placentation. As of 2009, the only successful treatment for preeclampsia is delivery. No definitive preventive strategies have been identified. However, several of the recent observations related to phenotypic causality provide stimuli for the development of novel therapies.
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Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101
Self-citationCirculating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720
Self-citationA Reversible Posterior Leukoencephalopathy Syndrome
Hinchey, J., Chaves, C., Appignani, B., Breen, J., Pao, L., Wang, A., Pessin, M. S., Lamy, C., Mas, J.-L., & Caplan, L. R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602223340803 · Cited by 3,340
Self-citationCirculating angiogenic factors and the risk of preeclampsia*
(2004) · Obstetrics & Gynecology · doi:10.1097/00006250-200405000-00028 · Cited by 2,615
Latest Advances in Understanding Preeclampsia
Redman, C. W., & Sargent, I. L. (2005) · Science · doi:10.1126/science.1111726 · Cited by 2,607
Preeclampsia: an endothelial cell disorder
Roberts, J. M., Taylor, R. N., Musci, T. J., Rodgers, G. M., Hubel, C. A., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90665-0 · Cited by 1,859
Soluble endoglin contributes to the pathogenesis of preeclampsia
Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855
Self-citationSoluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia
Levine, R. J., Lam, C., Qian, C., Yu, K. F., Maynard, S. E., Sachs, B. P., Sibai, B. M., Epstein, F. H., Romero, R., Thadhani, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055352 · Cited by 1,802
Self-citationRisk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
Duckitt, K., & Harrington, D. (2005) · BMJ · doi:10.1136/bmj.38380.674340.e0 · Cited by 1,784
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
Hanna, J., Goldman-Wohl, D., Hamani, Y., Avraham, I., Greenfield, C., Natanson-Yaron, S., Prus, D., Cohen-Daniel, L., Arnon, T. I., Manaster, I., et al. (2006) · Nature Medicine · doi:10.1038/nm1452 · Cited by 1,681
Cited by
Stepan, H., Galindo, A., Hund, M., Schlembach, D., Sillman, J., Surbek, D., & Vatish, M. (2023) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.26032 · Cited by 245
The Effects of Hemodynamic Force on Embryonic Development
CULVER, J. C., & DICKINSON, M. E. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00025.x · Cited by 173
Ishibashi, O., Ohkuchi, A., Ali, M. M., Kurashina, R., Luo, S.-S., Ishikawa, T., Takizawa, T., Hirashima, C., Takahashi, K., Migita, M., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.180232 · Cited by 173
Ambient Air Pollution and Preeclampsia: A Spatiotemporal Analysis
Dadvand, P., Figueras, F., Basagaña, X., Beelen, R., Martinez, D., Cirach, M., Schembari, A., Hoek, G., Brunekreef, B., & Nieuwenhuijsen, M. J. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1206430 · Cited by 145
Pre‐eclampsia and long‐term health outcomes for mother and infant: an umbrella review
Pittara, T., Vyrides, A., Lamnisos, D., & Giannakou, K. (2021) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16683 · Cited by 125
Metadata
- Authors
- Wang, A., Rana, S., & Karumanchi, S. A.
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2009-06
- Volume
- 24
- Issue
- 3
- Pages
- 147-158
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2138852027
- Cited by
- 549
- References
- 113
- FWCI
- 38.19
- Type
- journal article
- Language
- en
- Open access
- closed
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