Hydroxysteroid (17-β) Dehydrogenase 1 Is Dysregulated by Mir-210 and Mir-518c That Are Aberrantly Expressed in Preeclamptic Placentas: A Novel Marker for Predicting Preeclampsia
Abstract
In this study, to search for novel preeclampsia (PE) biomarkers, we focused on microRNA expression and function in the human placenta complicated with PE. By comprehensive analyses of microRNA expression, we identified 22 microRNAs significantly upregulated in preeclamptic placentas, 5 of which were predicted in silico to commonly target the mRNA encoding hydroxysteroid (17-β) dehydrogenase 1 (HSD17B1), a steroidogenetic enzyme expressed predominantly in the placenta. In vivo HSD17B1 expression, at both the mRNA and protein levels, was significantly decreased in preeclamptic placentas. Of these microRNAs, miR-210 and miR-518c were experimentally validated to target HSD17B1 by luciferase assay, real-time PCR, and ELISA. Furthermore, we found that plasma HSD17B1 protein levels in preeclamptic pregnant women reflected the decrease of its placental expression. Moreover, a prospective cohort study of plasma HSD17B1 revealed a significant reduction of plasma HSD17B1 levels in pregnant women at 20 to 23 and 27 to 30 weeks of gestation before PE onset compared with those with normal pregnancies. The sensitivities/specificities for predicting PE at 20 to 23 and 27 to 30 weeks of gestation were 0.75/0.67 (cutoff value=21.9 ng/mL) and 0.88/0.51 (cutoff value=30.5 ng/mL), and the odds ratios were 6.09 (95% CI: 2.35–15.77) and 7.83 (95% CI: 1.70–36.14), respectively. We conclude that HSD17B1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placenta and that reducing plasma level of HSD17B1 precedes the onset of PE and is a potential prognostic factor for PE.
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MiR-210 is increased in normal placentas from pregnancies at high altitude, and in placentas from pregnancies complicated by pre-eclampsia.
“It is increased in normal placentas from pregnancies at high altitude (121), and in placentas from pregnancies complicated by pre-eclampsia (272, 351, 401, 611).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [272]
Other targets identified for miR-210 include the steroidogenic enzyme hydroxysteroid (17-ß) dehydrogenase 1, ephrin-A3 and homeobox-A9 which are involved in trophoblast cell migration and vascular remodeling, and thrombospondin type 1 domain containing 7A in the placental vasculature.
“Besides mitochondria, other targets identified for miR-210 include the steroidogenic enzyme hydroxysteroid (17-ß) dehydrogenase 1 (272), ephrin-A3 and homeobox-A9 which are involved in trophoblast cell migration and vascular remodeling (611), and thrombospondin type 1 domain containing 7A in the placental vasculature (351).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [272]
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- Authors
- Ishibashi, O., Ohkuchi, A., Ali, M. M., Kurashina, R., Luo, S.-S., Ishikawa, T., Takizawa, T., Hirashima, C., Takahashi, K., Migita, M., Ishikawa, G., Yoneyama, K., Asakura, H., Izumi, A., Matsubara, S., Takeshita, T., & Takizawa, T.
- Affiliations
- Jichi Medical University (JP)
- ORCID
- Venue
- Hypertension
- Published
- 2012-02
- Volume
- 59
- Issue
- 2
- Pages
- 265-273
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1987627565
- Cited by
- 173
- References
- 31
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 11 · 2021: 15 · 2020: 11 · 2019: 11 · 2018: 17 · 2017: 13 · 2016: 16 · 2015: 19 · 2014: 14 · 2013: 18 · 2012: 5
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jichi Medical University
- China Medical University
- Japan Society for the Promotion of Science (22791554, 20390437, 23390386, 23592419)
- RIKEN
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- preeclampsia, HSD17B1, miR-210, microRNA, placenta, preeclampsia biomarkers, steroidogenesis, prognostic factors, microRNA target regulation
- MeSH terms
- Adult, Hypoxia, Cells, Cultured, Estradiol Dehydrogenases, Female, Humans, Placenta, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Prognosis, Prospective Studies, ROC Curve, Trophoblasts, Cohort Studies, Biomarkers, MicroRNAs
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