The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Mitochondrial Transporters as Novel Targets for Intracellular Calcium Signaling
Abstract
Ca 2+signaling in mitochondria is important to tune mitochondrial function to a variety of extracellular stimuli. The main mechanism is Ca 2+entry in mitochondria via the Ca 2+uniporter followed by Ca 2+activation of three dehydrogenases in the mitochondrial matrix. This results in increases in mitochondrial NADH/NAD ratios and ATP levels and increased substrate uptake by mitochondria. We review evidence gathered more than 20 years ago and recent work indicating that substrate uptake, mitochondrial NADH/NAD ratios, and ATP levels may be also activated in response to cytosolic Ca 2+signals via a mechanism that does not require the entry of Ca 2+in mitochondria, a mechanism depending on the activity of Ca 2+-dependent mitochondrial carriers (CaMC). CaMCs fall into two groups, the aspartate-glutamate carriers (AGC) and the ATP-Mg/P i carriers, also named SCaMC (for short CaMC). The two mammalian AGCs, aralar and citrin, are members of the malate-aspartate NADH shuttle, and citrin, the liver AGC, is also a member of the urea cycle. Both types of CaMCs are activated by Ca 2+in the intermembrane space and function together with the Ca 2+uniporter in decoding the Ca 2+signal into a mitochondrial response.
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Citations
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Metadata
- Authors
- Satrústegui, J., Pardo, B., & del Arco, A.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2007-01
- Volume
- 87
- Issue
- 1
- Pages
- 29-67
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2167378780
- Cited by
- 256
- References
- 18
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
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