The DOI matches its Crossref record; 278 of the 282 references it cites were found in a registry or an index.
Systemic Iron Homeostasis
Abstract
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content. Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and negatively regulated by the activity of erythrocyte precursors, the dominant consumers of iron. Hepcidin and ferroportin also play a role in host defense and inflammation, and hepcidin synthesis is induced by inflammatory signals including interleukin-6 and activin B. This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Macrophages are essential for systemic iron recycling, and also control iron availability to pathogens.”
From Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection (2015) · cites this paper as Ganz, 2013
In the citing paper
“The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells.”
From Pharmacological Targeting of the Hepcidin/Ferroportin Axis (2016) · cites this paper as Ganz, 2013
In the citing paper
“Amongst these, hepcidin stands out as the central regulator of systemic iron balance [14].”
From Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans (2015) · cites this paper as [14]
Citations
Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Self-citationCloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 2×
“Subsequently, microbial molecules, the plant-derived inflammatory agent turpentine, and cytokines were shown to be potent inducers of hepcidin synthesis (162, 165, 168, 186).”
BackgroundSelf-citationHepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Self-citationTwo to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Identification of the haemoglobin scavenger receptor
Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H.-J., Law, S. K. A., & Moestrup, S. K. (2001) · Nature · doi:10.1038/35051594 · Cited by 1,712
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
Self-citation
Flagged first, then by citations
4 of the 282 references couldn’t be matched to a known paper.
Research works printed but not linked: 15
- Akinc A, 2011, 53rd ASH Annu Meet Abstr, 688
- Aoki CA, 2005, J Clin Gastroenterol, 39, 71
- Beutler E, 2007, ASH Annu Meet Abstr, 110, 3
- Booten S, 2011, 53rd ASH Annu Meet Abstr, 1047
- Cazzola M, 1989, Prog Clin Biol Res, 309, 93
- Centers for Disease Control and Prevention, 2011, Morb Mortal Wkly Rep, 60, 201
- 10.3324/haematol.2010.033449 · DOI
- Hohlbaum AM, 2011, 53rd ASH Annu Meet Abstr, 687
- Kwiatkowski JL, 2011, ASH Education Program Book, 2011, 451
- Mackenzie Bryan, 2011, FASEB J, 25
- Mitchell CJ, 2010, FASEB J, 24
- Nemeth E, 2006, Haematologica, 91, 727
- Riecke K, 2012, 54rd ASH Annu Meet Abstr, 2342
- Van Eijk L, 2012, 54rd ASH Ann Meet Abstr, 3452
- Wyllie JC, 1982, Lab Invest, 47, 471
Cited by
Sorted by citations
Ferroptosis as a target for protection against cardiomyopathy
Fang, X., Wang, H., Han, D., Xie, E., Yang, X., Wei, J., Gu, S., Gao, F., Zhu, N., Yin, X., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821022116 · Cited by 2,163
Weiss, G., Ganz, T., & Goodnough, L. T. (2019) · Blood · doi:10.1182/blood-2018-06-856500 · Cited by 1,219
Self-citationMechanisms of action of plant growth promoting bacteria
Olanrewaju, O. S., Glick, B. R., & Babalola, O. O. (2017) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-017-2364-9 · Cited by 1,203
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
Fang, X., Ardehali, H., Min, J., & Wang, F. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00735-4 · Cited by 1,121
Iron homeostasis in host defence and inflammation
Ganz, T., & Nemeth, E. (2015) · Nature Reviews Immunology · doi:10.1038/nri3863 · Cited by 843
Self-citation
Metadata
- Authors
- Ganz, T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ganz, Tomas
- ORCID
- Ganz, Tomas
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2013-10
- Volume
- 93
- Issue
- 4
- Pages
- 1721-1741
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2170885365
- Cited by
- 1,122
- References
- 282
- Citations by year
- 2026: 77 · 2025: 91 · 2024: 89 · 2023: 107 · 2022: 91 · 2021: 95 · 2020: 90 · 2019: 67 · 2018: 78 · 2017: 91 · 2016: 97 · 2015: 83 · 2014: 63 · 2013: 1
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- iron homeostasis, hepcidin, ferroportin, intestinal iron absorption, erythroid precursors, inflammation, interleukin-6, activin B, iron deficiency, iron overload
- MeSH terms
- Ferroportin, Amino Acid Sequence, Hemostasis, Humans, Iron, Macrophages, Molecular Sequence Data, Hepatocytes, Cation Transport Proteins, Hepcidins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
