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Cited by 849

The DOI matches its Crossref record; 255 of the 255 references it cites were found in a registry or an index.

Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration

Le Clainche, Christophe, Carlier, Marie-France·2008·Physiological Reviews

Abstract

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this process. The first part of this review (sect. ii) describes the formation of the lamellipodial and filopodial actin networks. In lamellipodia, the WASP-Arp2/3 pathways generate a branched filament array. This polarized dendritic actin array is maintained in rapid treadmilling by the concerted action of ADF, profilin, and capping proteins. In filopodia, formins catalyze the processive assembly of nonbranched actin filaments. Cell matrix adhesions mechanically couple actin filaments to the substrate to convert the treadmilling into protrusion and the actomyosin contraction into traction of the cell body and retraction of the tail. The second part of this review (sect. iii) focuses on the function and the regulation of major proteins (vinculin, talin, tensin, and α-actinin) that control the nucleation, the binding, and the barbed-end growth of actin filaments in adhesions.

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Crossref · 10.1152/physrev.00021.2007

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Metadata

Authors
Le Clainche, C., & Carlier, M.-F.
Venue
Physiological Reviews
Published
2008-04
Volume
88
Issue
2
Pages
489-513
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W2105809801
Cited by
849
References
255
FWCI
3.65
Type
journal article
Language
en
Open access
closed

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