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Cited by 286

The DOI matches its Crossref record; 613 of the 613 references it cites were found in a registry or an index.

Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation

Open access
Wettschureck, Nina, Strilic, Boris, Offermanns, Stefan·2019·Physiological Reviews
DOI 10.1152/physrev.00037.2018
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Abstract

A central function of the vascular endothelium is to serve as a barrier between the blood and the surrounding tissue of the body. At the same time, solutes and cells have to pass the endothelium to leave or to enter the bloodstream to maintain homeostasis. Under pathological conditions, for example, inflammation, permeability for fluid and cells is largely increased in the affected area, thereby facilitating host defense. To appropriately function as a regulated permeability filter, the endothelium uses various mechanisms to allow solutes and cells to pass the endothelial layer. These include transcellular and paracellular pathways of which the latter requires remodeling of intercellular junctions for its regulation. This review provides an overview on endothelial barrier regulation and focuses on the endothelial signaling mechanisms controlling the opening and closing of paracellular pathways for solutes and cells such as leukocytes and metastasizing tumor cells.

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Crossref · 10.1152/physrev.00037.2018

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Metadata

Authors
Wettschureck, N., Strilic, B., & Offermanns, S.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2019-07-01
Volume
99
Issue
3
Pages
1467-1525
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00037.2018
OpenAlex
W2947593497
Cited by
286
References
613
FWCI
4.25
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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