Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation

Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

Dudek, S. M., Jacobson, J. R., Chiang, E. T., Birukov, K. G., Wang, P., Zhan, X., & Garcia, J. G. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313969200 · Cited by 301

Real-Time Imaging of Vascular Endothelial-Cadherin During Leukocyte Transmigration Across Endothelium

Shaw, S. K., Bamba, P. S., Perkins, B. N., & Luscinskas, F. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2323 · Cited by 300

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

Coon, B. G., Baeyens, N., Han, J., Budatha, M., Ross, T. D., Fang, J. S., Yun, S., Thomas, J.-L., & Schwartz, M. A. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201408103 · Cited by 299

ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines

Etienne-Manneville, S., Manneville, J.-B., Adamson, P., Wilbourn, B., Greenwood, J., & Couraud, P.-O. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3375 · Cited by 298

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

Adamson, P., Etienne, S., Couraud, P.-O., Calder, V., & Greenwood, J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2964 · Cited by 296

Gap Junctions in the Control of Vascular Function

Figueroa, X. F., & Duling, B. R. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2117 · Cited by 294

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

Wolf, M. J., Hoos, A., Bauer, J., Boettcher, S., Knust, M., Weber, A., Simonavicius, N., Schneider, C., Lang, M., Stürzl, M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.023 · Cited by 290

Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation

Birukova, A. A., Zagranichnaya, T., Fu, P., Alekseeva, E., Chen, W., Jacobson, J. R., & Birukov, K. G. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.036 · Cited by 285

Stabilizing the VE‐cadherin–catenin complex blocks leukocyte extravasation and vascular permeability

Schulte, D., Küppers, V., Dartsch, N., Broermann, A., Li, H., Zarbock, A., Kamenyeva, O., Kiefer, F., Khandoga, A., Massberg, S., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.304 · Cited by 284

Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners

Burns, A. R., Walker, D. C., Brown, E. S., Thurmon, L. T., Bowden, R. A., Keese, C. R., Simon, S. I., Entman, M. L., & Smith, C. W. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.6.2893 · Cited by 284

Blood cells and endothelial barrier function

Rodrigues, S. F., & Granger, D. N. (2015) · Tissue Barriers · doi:10.4161/21688370.2014.978720 · Cited by 284

Tie1 controls angiopoietin function in vascular remodeling and inflammation

Korhonen, E. A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D’Amico, G., Sipilä, T. J., Lohela, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84923 · Cited by 283

The subendothelial extracellular matrix modulates NF-κB activation by flow

Orr, A. W., Sanders, J. M., Bevard, M., Coleman, E., Sarembock, I. J., & Schwartz, M. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410073 · Cited by 283

Site-Specific MicroRNA-92a Regulation of Krüppel-Like Factors 4 and 2 in Atherosusceptible Endothelium

Fang, Y., & Davies, P. F. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.244053 · Cited by 282

p120-Catenin Regulates Clathrin-dependent Endocytosis of VE-Cadherin

Xiao, K., Garner, J., Buckley, K. M., Vincent, P. A., Chiasson, C. M., Dejana, E., Faundez, V., & Kowalczyk, A. P. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-05-0440 · Cited by 282

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

Huang, R.-L., Teo, Z., Chong, H. C., Zhu, P., Tan, M. J., Tan, C. K., Lam, C. R. I., Sng, M. K., Leong, D. T. W., Tan, S. M., et al. (2011) · Blood · doi:10.1182/blood-2011-01-328716 · Cited by 281

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

Wu, W., Xiao, H., Laguna-Fernandez, A., Villarreal, G., Wang, K.-C., Geary, G. G., Zhang, Y., Wang, W.-C., Huang, H.-D., Zhou, J., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.005108 · Cited by 280

The Vesiculo–Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle

Dvorak, A. M., & Feng, D. (2001) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540104900401 · Cited by 279

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.

Feng, D., Nagy, J. A., Hipp, J., Dvorak, H. F., & Dvorak, A. M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.5.1981 · Cited by 278

Delayed Onset of Inflammation in Protease-Activated Receptor-2-Deficient Mice

Lindner, J. R., Kahn, M. L., Coughlin, S. R., Sambrano, G. R., Schauble, E., Bernstein, D., Foy, D., Hafezi-Moghadam, A., & Ley, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6504 · Cited by 274

Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction

Birukova, A. A., Smurova, K., Birukov, K. G., Kaibuchi, K., Garcia, J. G. N., & Verin, A. D. (2004) · Microvascular Research · doi:10.1016/j.mvr.2003.09.007 · Cited by 272

Platelets in atherosclerosis

Hundelshausen, P. V., & Lievens, D. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-08-0592 · Cited by 271

Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering

Wójciak-Stothard, B., Williams, L., & Ridley, A. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.6.1293 · Cited by 269

Cortactin branches out: Roles in regulating protrusive actin dynamics

Ammer, A. G., & Weed, S. A. (2008) · Cell Motility · doi:10.1002/cm.20296 · Cited by 267

The Complex Role of Angiopoietin-2 in the Angiopoietin-Tie Signaling Pathway

Thurston, G., & Daly, C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006650 · Cited by 266

Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE

Bennett, J., Basivireddy, J., Kollar, A., Biron, K. E., Reickmann, P., Jefferies, W. A., & McQuaid, S. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.011 · Cited by 265

Platelets and Chemokines in Atherosclerosis: Partners in Crime

Weber, C. (2005) · Circulation Research · doi:10.1161/01.res.0000160077.17427.57 · Cited by 265

Regulation of NF‐κB by deubiquitinases

Harhaj, E. W., & Dixit, V. M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01100.x · Cited by 260

Intercellular adhesion molecule-1 gene expression in human endothelial cells. Differential regulation by tumor necrosis factor-alpha and phorbol myristate acetate.

Wertheimer, S. J., Myers, C. L., Wallace, R. W., & Parks, T. P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49801-3 · Cited by 257

Molecular sieving characteristics of the cultured endothelial monolayer

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Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness

Galaup, A., Cazes, A., Le Jan, S., Philippe, J., Connault, E., Le Coz, E., Mekid, H., Mir, L. M., Opolon, P., Corvol, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609025103 · Cited by 252

Transient and Steady-State Effects of Shear Stress on Endothelial Cell Adherens Junctions

Noria, S., Cowan, D. B., Gotlieb, A. I., & Langille, B. L. (1999) · Circulation Research · doi:10.1161/01.res.85.6.504 · Cited by 252

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

Daly, C., Pasnikowski, E., Burova, E., Wong, V., Aldrich, T. H., Griffiths, J., Ioffe, E., Daly, T. J., Fandl, J. P., Papadopoulos, N., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607538103 · Cited by 251

Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties

Stelzner, T. J., Weil, J. V., & O'Brien, R. F. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041390122 · Cited by 251

Roles of Rho/ROCK and MLCK in TNF‐α‐induced changes in endothelial morphology and permeability

McKenzie, J. A. G., & Ridley, A. J. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21114 · Cited by 251

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability

Wegmann, F., Petri, B., Khandoga, A. G., Moser, C., Khandoga, A., Volkery, S., Li, H., Nasdala, I., Brandau, O., Fässler, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060565 · Cited by 250

Mind the gap: mechanisms regulating the endothelial barrier

Radeva, M. Y., & Waschke, J. (2018) · Acta Physiologica · doi:10.1111/apha.12860 · Cited by 249

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

Etienne, S., Adamson, P., Greenwood, J., Strosberg, A. D., Cazaubon, S., & Couraud, P.-O. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5755 · Cited by 248

Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis

Huang, Y., Song, N., Ding, Y., Yuan, S., Li, X., Cai, H., Shi, H., & Luo, Y. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4382 · Cited by 247

Endothelial cell-cell adhesion and signaling

Cerutti, C., & Ridley, A. J. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.06.003 · Cited by 244

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

Kim, M., Allen, B., Korhonen, E. A., Nitschké, M., Yang, H. W., Baluk, P., Saharinen, P., Alitalo, K., Daly, C., Thurston, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84871 · Cited by 243

Protein kinase signaling in the modulation of microvascular permeability

Yuan, S. Y. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(03)00010-7 · Cited by 242

Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration

Shaw, S. K., Ma, S., Kim, M. B., Rao, R. M., Hartman, C. U., Froio, R. M., Yang, L., Jones, T., Liu, Y., Nusrat, A., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040965 · Cited by 241

Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions

Andriopoulou, P., Navarro, P., Zanetti, A., Lampugnani, M. G., & Dejana, E. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.10.2286 · Cited by 240

Ca2+ Signaling, TRP Channels, and Endothelial Permeability

TIRUPPATHI, C., AHMMED, G. U., VOGEL, S. M., & MALIK, A. B. (2006) · Microcirculation · doi:10.1080/10739680600930347 · Cited by 239

Shear stress stimulates phosphorylation of eNOS at Ser635by a protein kinase A-dependent mechanism

Boo, Y. C., Hwang, J., Sykes, M., Michell, B. J., Kemp, B. E., Lum, H., & Jo, H. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00214.2002 · Cited by 239

YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6

Lv, Y., Kim, K., Sheng, Y., Cho, J., Qian, Z., Zhao, Y.-Y., Hu, G., Pan, D., Malik, A. B., & Hu, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.313143 · Cited by 239

Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

Durieu-Trautmann, O., Chaverot, N., Cazaubon, S., Strosberg, A. D., & Couraud, P. O. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99908-4 · Cited by 237

VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

Sun, Z., Li, X., Massena, S., Kutschera, S., Padhan, N., Gualandi, L., Sundvold-Gjerstad, V., Gustafsson, K., Choy, W. W., Zang, G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111343 · Cited by 237

Vascular endothelial cell Toll-like receptor pathways in sepsis

Khakpour, S., Wilhelmsen, K., & Hellman, J. (2015) · Innate Immunity · doi:10.1177/1753425915606525 · Cited by 234

Endothelial permeability and VE-cadherin: A wacky comradeship

Gavard, J. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.29026 · Cited by 234

The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition

Stan, R. V., Tse, D., Deharvengt, S. J., Smits, N. C., Xu, Y., Luciano, M. R., McGarry, C. L., Buitendijk, M., Nemani, K. V., Elgueta, R., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.11.003 · Cited by 232

Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

Wallez, Y., Cand, F., Cruzalegui, F., Wernstedt, C., Souchelnytskyi, S., Vilgrain, I., & Huber, P. (2007) · Oncogene · doi:10.1038/sj.onc.1209855 · Cited by 231

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

Nottebaum, A. F., Cagna, G., Winderlich, M., Gamp, A. C., Linnepe, R., Polaschegg, C., Filippova, K., Lyck, R., Engelhardt, B., Kamenyeva, O., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080406 · Cited by 229

Extracellular matrix protein βig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation

Ma, C., Rong, Y., Radiloff, D. R., Datto, M. B., Centeno, B., Bao, S., Cheng, A. W. M., Lin, F., Jiang, S., Yeatman, T. J., et al. (2008) · Genes & Development · doi:10.1101/gad.1632008 · Cited by 224

Axl is essential for VEGF‐A‐dependent activation of PI3K/Akt

Ruan, G., & Kazlauskas, A. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.21 · Cited by 223

Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis

Brodt, P., Fallavollita, L., Bresalier, R. S., Meterissian, S. H., Norton, C. R., & Wolitzky, B. A. (1997) · International Journal of Cancer · Cited by 223

Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli

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Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

Frye, M., Dierkes, M., Küppers, V., Vockel, M., Tomm, J., Zeuschner, D., Rossaint, J., Zarbock, A., Koh, G. Y., Peters, K., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150718 · Cited by 222

Temporal Gradient in Shear But Not Steady Shear Stress Induces PDGF-A and MCP-1 Expression in Endothelial Cells: Role of NO, NFκB, and egr-1

Bao, X., Lu, C., & Frangos, J. A. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.996 · Cited by 220

Role of Src-induced Dynamin-2 Phosphorylation in Caveolae-mediated Endocytosis in Endothelial Cells

Shajahan, A. N., Timblin, B. K., Sandoval, R., Tiruppathi, C., Malik, A. B., & Minshall, R. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308710200 · Cited by 219

Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation

Reglero-Real, N., Colom, B., Bodkin, J. V., & Nourshargh, S. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.307610 · Cited by 218

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

Shen, J., Frye, M., Lee, B. L., Reinardy, J. L., McClung, J. M., Ding, K., Kojima, M., Xia, H., Seidel, C., Silva, R. L. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74527 · Cited by 217

Platelets Guide Leukocytes to Their Sites of Extravasation

Zuchtriegel, G., Uhl, B., Puhr-Westerheide, D., Pörnbacher, M., Lauber, K., Krombach, F., & Reichel, C. A. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002459 · Cited by 217

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

Holopainen, T., Saharinen, P., D’Amico, G., Lampinen, A., Eklund, L., Sormunen, R., Anisimov, A., Zarkada, G., Lohela, M., Heloterä, H., et al. (2012) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djs009 · Cited by 216

The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.

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Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

Oo, M. L., Chang, S.-H., Thangada, S., Wu, M.-T., Rezaul, K., Blaho, V., Hwang, S.-I., Han, D. K., & Hla, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45403 · Cited by 216

Vascular Endothelial Growth Factor Modulates the Transendothelial Migration of MDA-MB-231 Breast Cancer Cells through Regulation of Brain Microvascular Endothelial Cell Permeability

Lee, T.-H., Avraham, H. K., Jiang, S., & Avraham, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210063200 · Cited by 214

The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen Species

Monaghan-Benson, E., & Burridge, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009894 · Cited by 213

Identification of Regulatory Sites of Phosphorylation of the Bovine Endothelial Nitric-oxide Synthase at Serine 617 and Serine 635

Michell, B. J., Harris, M. B., Chen, Z.-P., Ju, H., Venema, V. J., Blackstone, M. A., Huang, W., Venema, R. C., & Kemp, B. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205144200 · Cited by 212

Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees

Dejana, E., Orsenigo, F., Molendini, C., Baluk, P., & McDonald, D. M. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0694-5 · Cited by 210

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

Beckers, C., van Hinsbergh, V., & van Nieuw Amerongen, G. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-06-0403 · Cited by 209

Endothelial Cells Proactively Form Microvilli-Like Membrane Projections upon Intercellular Adhesion Molecule 1 Engagement of Leukocyte LFA-1

Carman, C. V., Jun, C.-D., Salas, A., & Springer, T. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6135 · Cited by 209

RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration

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Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation

Zhong, L., Simard, M. J., & Huot, J. (2018) · The FASEB Journal · doi:10.1096/fj.201701536r · Cited by 207

Novel role of microtubules in thrombin‐induced endothelial barrier dysfunction

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Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

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The Role of VE-Cadherin in Vascular Morphogenesis and Permeability Control

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P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

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Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems

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Blocking NF-κB: An Inflammatory Issue

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Cell surface levels of endothelial ICAM‐1 influence the transcellular or paracellular T‐cell diapedesis across the blood–brain barrier

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Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

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Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species

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Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells

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Monocytes Induce Reversible Focal Changes in Vascular Endothelial Cadherin Complex during Transendothelial Migration under Flow

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Cyclic AMP: a selective modulator of NF-κB action

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Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions'

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