The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy
Abstract
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB), making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely and effectively penetrate the BBB to achieve targeted drug delivery to brain tumors has been a challenging research problem. With the intensive research in micro‐ and nanotechnology in recent years, nano drug‐targeted delivery technologies have shown great potential to overcome this challenge, such as inorganic nanocarriers, organic polymer‐carriers, liposomes, and biobased carriers, which can be designed in different sizes, shapes, and surface functional groups to enhance their ability to penetrate the BBB and targeted drug delivery for brain tumors. In this review, the composition and overcoming patterns of the BBB are detailed, and then the hot research topics of drug delivery carriers for brain tumors in recent years are summarized, and their mechanisms of action on the BBB and the factors affecting drug delivery are described in detail, and the effectiveness of targeted therapy for brain tumors is evaluated. Finally, the challenges and dilemmas in developing brain tumor drug delivery systems are discussed, which will be promising in the future for targeted drug delivery to brain tumors based on micro‐nanocarriers technology.
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“These coatings confirm that the material is released in the tumor microenvironment, while traditional carriers would have the potential for leaks and off-target effects [89].”
From Advances in green-synthesized magnetic nanoparticles for targeted cancer therapy: mechanisms, applications, and future perspectives (2026) · cites this paper as [89]
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“These coatings confirm that the material is released in the tumor microenvironment, while traditional carriers would have the potential for leaks and off-target effects [89].”
From Advances in green-synthesized magnetic nanoparticles for targeted cancer therapy: mechanisms, applications, and future perspectives (2026) · cites this paper as [89]
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Mfsd2a is critical for the formation and function of the blood-brain barrier
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Sorted by citations
El-khawaga, A. M., Youssef, O. I., El-dydamoni, O. A., Ragab, W. M., & Mohammed, R. A. E. (2026) · European Journal of Medical Research · doi:10.1186/s40001-025-03804-9 · Cited by 14
Metadata
- Authors
- Wang, L., Shi, Y., Jiang, J., Li, C., Zhang, H., Zhang, X., Jiang, T., Wang, L., Wang, Y., & Feng, L.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2022-09-14
- Volume
- 18
- Issue
- 45
- ISSN
- 1613-6810
- 1613-6829
- Cited by
- 71
- References
- 19
- Language
- en
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