eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Nitric oxide synthases: structure, function and inhibition

ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110

Compensatory Enlargement of Human Atherosclerotic Coronary Arteries

Glagov, S., Weisenberg, E. S., Zarins, C. K., Stankunavicius, R., & Kolettis, G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198705283162204 · Cited by 3,614

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591

The Protective Effects of Estrogen on the Cardiovascular System

Mendelsohn, M. E., & Karas, R. H. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402306 · Cited by 3,119

Nitric oxide synthases: Roles, tolls, and controls

Nathan, C., & Xie, Q. W. (1994) · Cell · doi:10.1016/0092-8674(94)90266-6 · Cited by 2,920

Flow-mediated endothelial mechanotransduction

Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802

Postmenopausal Estrogen Therapy and Cardiovascular Disease

Stampfer, M. J., Colditz, G. A., Willett, W. C., Manson, J. E., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109123251102 · Cited by 2,000

VEGF contributes to postnatal neovascularization by mobilizing bone marrow‐derived endothelial progenitor cells

Asahara, T., Takahashi, T., Masuda, H., Kalka, C., Chen, D., Iwaguro, H., Inai, Y., Silver, M., & Isner, J. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3964 · Cited by 1,851

Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., Crystal, R. G., Besmer, P., Lyden, D. C., Moore, M. A. S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00754-7 · Cited by 1,744

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D., Engelhardt, B., Cao, G., DeLisser, H. M., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,738

Hypoxia-Inducible Factor-1 (HIF-1)

Ke, Q., & Costa, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027029 · Cited by 1,690

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

Maniotis, A. J., Chen, C. S., & Ingber, D. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.849 · Cited by 1,630

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

Dráb, M., Verkade, P., Elger, M., Kasper, M. E., Löhn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., et al. (2001) · Science · doi:10.1126/science.1062688 · Cited by 1,555

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

Simoncini, T., Hafezi‐Moghadam, A., Brazil, D. P., Ley, K. F., Chin, W. W., & Liao, J. K. (2000) · Nature · doi:10.1038/35035131 · Cited by 1,436

Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease

Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

Aicher, A., Heeschen, C., Mildner-Rihm, C., Urbich, C., Ihling, C. H., Technau‐Ihling, K., Zeiher, A. M., & Dimmeler, S. (2003) · Nature Medicine · doi:10.1038/nm948 · Cited by 1,311

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,195

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

Razani, B., Engelman, J. A., Wang, X., Schubert, W., Zhang, X. L., Marks, C. B., Macaluso, F., Russell, R. G., Li, M., Pestell, R. G., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105408200 · Cited by 1,186

Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent

Langille, B. L., & O'Donnell, F. E. (1986) · Science · doi:10.1126/science.3941904 · Cited by 1,121

Effect of exercise training on endothelium‐derived nitric oxide function in humans

Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040

Dynamic activation of endothelial nitric oxide synthase by Hsp90

García‐Cardeña, G., Fan, R., Shah, V. H., Sorrentino, R., Cirino, G., Papapetropoulos, A., & Sessa, W. C. (1998) · Nature · doi:10.1038/33934 · Cited by 1,029

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

Glagov, S., Zarins, C. K., Giddens, D. P., & Ku, D. N. (1988) · PubMed · Cited by 1,029

Nitric oxide synthases: which, where, how, and why?

Michel, T. M., & Féron, O. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119750 · Cited by 1,024

Haemodynamic shear stress activates a K+ current in vascular endothelial cells

Olesen, S., Clapham, D. E., & Davies, P. F. (1988) · Nature · doi:10.1038/331168a0 · Cited by 1,010

Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress

Cheng, C., Tempel, D., van Haperen, R., van der Baan, A., Grosveld, F. G., Daemen, M. J. A. P., Krams, R., & de Crom, R. (2006) · Circulation · doi:10.1161/circulationaha.105.590018 · Cited by 1,002

Modulation of Akt kinase activity by binding to Hsp90

Sato, S., Fujita, N., & Tsuruo, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170276797 · Cited by 967

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

Gu, Z., Kaul, M., Yan, B., Kridel, S. J., Cui, J., Strongin, A., Smith, J. W., Liddington, R. C., & Lipton, S. A. (2002) · Science · doi:10.1126/science.1073634 · Cited by 950

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

Fleming, I., & Busse, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00323.2002 · Cited by 941

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

Chen, Z., Yuhanna, I. S., Galcheva-Gargova, Z., Karas, R. H., Mendelsohn, M. E., & Shaul, P. W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5347 · Cited by 924

Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.

Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H. T., Donnini, S., Granger, H. J., & Bicknell, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119451 · Cited by 909

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907

SIRT1 Promotes Endothelium-Dependent Vascular Relaxation by Activating Endothelial Nitric Oxide Synthase

Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881

Restenosis After Successful Percutaneous Transluminal Coronary Angioplasty: Serial Angiographic Follow-Up of 229 Patients

Nobuyoshi, M., Kimura, T., Nosaka, H., Mioka, S., Ueno, K., 横井, 博., Hamasaki, N., Horiuchi, H., & Ohishi, H. (1988) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(88)80046-9 · Cited by 875

Ion Channels and Their Functional Role in Vascular Endothelium

Nilius, B., & Droogmans, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1415 · Cited by 868

Physical Training Increases Endothelial Progenitor Cells, Inhibits Neointima Formation, and Enhances Angiogenesis

Laufs, U., Werner, N., Link, A., Endres, M., Waßmann, S., Jürgens, K., Miche, E., Böhm, M., & Nickenig, G. (2003) · Circulation · doi:10.1161/01.cir.0000109141.48980.37 · Cited by 858

Nitric oxide synthase: Aspects concerning structure and catalysis

Marletta, M. A. (1994) · Cell · doi:10.1016/0092-8674(94)90268-2 · Cited by 851

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 839

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

Rudic, R. D., Shesely, E. G., Maeda, N., Smithies, O., Segal, S. S., & Sessa, W. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1699 · Cited by 821

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 794

Phosphorylation of Thr 495 Regulates Ca 2+ /Calmodulin-Dependent Endothelial Nitric Oxide Synthase Activity

Fleming, I., Fisslthaler, B., Dimmeler, S., Kemp, B. E., & Busse, R. (2001) · Circulation Research · doi:10.1161/hh1101.092677 · Cited by 770

Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure

Kojda, G. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00169-8 · Cited by 769

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

Barouch, L. A., Harrison, R. W., Skaf, M. W., Rosas, G. O., Cappola, T. P., Kobeissi, Z. A., Hobai, I. A., Lemmon, C. A., Burnett, A. L. “., O'Rourke, B. P., et al. (2002) · Nature · doi:10.1038/416337a · Cited by 760

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

Russell, R. R., Li, J., Coven, D. L., Pypaert, M., Zechner, C., Palmeri, M., Giordano, F. J., Mu, J., Birnbaum, M. J., & Young, L. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19297 · Cited by 738

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S., Uematsu, M., Nerem, R. M., Alexander, R. W., & Murphy, T. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116092 · Cited by 735

Antioxidants and Oxidative Stress in Exercise

Ji, L. L. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-145.x · Cited by 734

KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation

SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 734

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704

Postmenopausal Estrogen Therapy and Cardiovascular Disease

MacLean, D. B., & Bostom, A. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199203053261012 · Cited by 703

Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women

Lieberman, E. H., Gerhard, M. D., Uehata, A., Walsh, B. W., Selwyn, A. P., Ganz, P., Yeung, A. C., & Creager, M. A. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00005 · Cited by 701

Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells

Suárez, Y., Fernandez-Hernando, C. F., Pober, J. S., & Sessa, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000265065.26744.17 · Cited by 697

Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity

Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2)

Dekker, R. J., van Soest, S., Fontijn, R. D., Salamanca, S., de Groot, P. G., VanBavel, E., Pannekoek, H., & Horrevoets, A. J. G. (2002) · Blood · doi:10.1182/blood-2002-01-0046 · Cited by 694

Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction

Lee, S. H., Wolf, P. L., Escudero, R., Deutsch, R., Jamieson, S. W., & Thistlethwaite, P. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003023420904 · Cited by 693

Effects of Exercise Training on Left Ventricular Function and Peripheral Resistance in Patients With Chronic Heart Failure: A Randomized Trial

Hambrecht, R. (2000) · JAMA · doi:10.1001/jama.283.23.3095 · Cited by 689

Peroxynitrite reductase activity of bacterial peroxiredoxins

Bryk, R., Griffin, P. R., & Nathan, C. (2000) · Nature · doi:10.1038/35025109 · Cited by 679

Nitric oxide metabolism and breakdown

Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673

The enigma of Mayer waves: facts and models.

JULIEN, C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.008 · Cited by 670

Endothelial Nitric Oxide Synthase Targeting to Caveolae

Féron, O., Belhassen, L., Kobzik, L., Smith, T. W., Kelly, R. A., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22810 · Cited by 670

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

Balligand, J., Kelly, R. A., Marsden, P. A., Smith, T. W., & Michel, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.347 · Cited by 659

Sex Differences in Coronary Heart Disease

Barrett-Connor, E. L. (1997) · Circulation · doi:10.1161/01.cir.95.1.252 · Cited by 648

Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

Kuhlencordt, P., Gyurko, R., Han, F., Scherrer‐Crosbie, M., Aretz, T. H., Hajjar, R. J., Picard, M. H., & Huang, P. L. (2001) · Circulation · doi:10.1161/hc2901.091399 · Cited by 628

Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo

Nieuwdorp, M., van Haeften, T. W., Gouverneur, M., Mooij, H. L., van Lieshout, M. H. P., Levi, M. M., Meijers, J. C. M., Holleman, F., Hoekstra, J. B. L., Vink, H., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1103 · Cited by 628

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase

Raman, C. S., Li, H., Pavel Martasek, E., Král, V., Masters, B. S. S., & Poulos, T. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81718-3 · Cited by 626

Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells

Florian, J. A., Kosky, J. R., Ainslie, K. M., Pang, Z., Dull, R. O., & Tarbell, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000101744.47866.d5 · Cited by 619

Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

Li, S. C., Okamoto, T., Chun, M., Sargiacomo, M., Casanova, J. E., Hansen, S. H., Nishimoto, I., & Lisanti, M. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15693 · Cited by 608

Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State

Keulenaer, G. W. D., Chappell, D. C., Ishizaka, N., Nerem, R. M., Alexander, R. W., & Griendling, K. K. (1998) · Circulation Research · doi:10.1161/01.res.82.10.1094 · Cited by 605

Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602

Cardioprotective Function of Inducible Nitric Oxide Synthase and Role of Nitric Oxide in Myocardial Ischemia and Preconditioning: an Overview of a Decade of Research

Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 601

Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

Hafezi‐Moghadam, A., Simoncini, T., Yang, Z., Limbourg, F. P., Plumier, J.-C., Rebsamen, M. C., Hsieh, C.-M., Chui, D.-S., Thomas, K. L., Prorock, A. J., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-473 · Cited by 596

The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization

Kopp, H., Avecilla, S. T., Hooper, A. T., & Rafii, S. (2005) · Physiology · doi:10.1152/physiol.00025.2005 · Cited by 581

Estrogen Modulation of Endothelial Nitric Oxide Synthase

Chambliss, K. L., & Shaul, P. W. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0045 · Cited by 572

Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress

Uematsu, M., Ohara, Y., Navas, J. P., Nishida, K., Murphy, T. J., Alexander, R. W., Nerem, R. M., & Harrison, D. G. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.6.c1371 · Cited by 571

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

Bucci, M., Gratton, J., Rudic, R. D., Acevedo, L. M., Roviezzo, F., Cirino, G., & Sessa, W. C. (2000) · Nature Medicine · doi:10.1038/82176 · Cited by 566

Nitric Oxide and Cardiac Function

Massion, P. B., Féron, O., Dessy, C., & Balligand, J. (2003) · Circulation Research · doi:10.1161/01.res.0000088351.58510.21 · Cited by 566

Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

Michell, B. J., Chen, Z., Tiganis, T., Stapleton, D., Katsis, F., Power, D. A., Sim, A. T. R., & Kemp, B. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100122200 · Cited by 560

S-nitrosylation in health and disease

Foster, M. W., McMahon, T., & Stamler, J. S. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00028-5 · Cited by 558

Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training

Fukai, T., Siegfried, M. R., Ushio‐Fukai, M., Cheng, Y., Kojda, G., & Harrison, D. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9551 · Cited by 555

Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway

Vallance, P., & Leiper, J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000128897.54893.26 · Cited by 553

Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium

Chappell, D. C., Varner, S. E., Nerem, R. M., Medford, R. M., & Alexander, R. W. (1998) · Circulation Research · doi:10.1161/01.res.82.5.532 · Cited by 548

Regulation of Endothelial Nitric Oxide Synthase: Location, Location, Location

Shaul, P. W. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.155952 · Cited by 545

Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression

Torella, D., Rota, M., Nurzyńska, D., Musso, E., Monsen, A., Shiraishi, I., Zias, E. A., Walsh, K. X., Rosenzweig, A., Sussman, M. A., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000117306.10142.50 · Cited by 538

Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.

Reís, S. E., Gloth, S. T., Blumenthal, R. S., Resar, J. R., Zacur, H. A., Gerstenblith, G., & Brinker, J. A. (1994) · Circulation · doi:10.1161/01.cir.89.1.52 · Cited by 530

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization

Potente, M., Urbich, C., Sasaki, K., Hofmann, W. K., Heeschen, C., Aicher, A., Kollipara, R., DePinho, R. A., Zeiher, A. M., & Dimmeler, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23126 · Cited by 527

Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells

Kuchan, M. J., & Frangos, J. A. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.3.c628 · Cited by 516

Post-Translational Control of Endothelial Nitric Oxide Synthase: Why Isn't Calcium/Calmodulin Enough?

Fulton, D. J., Gratton, J., & Sessa, W. C. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29198-9 · Cited by 499

Nitric oxide synthase in cardiac sarcoplasmic reticulum

Xu, K. Y., Huso, D. L., Dawson, T. M., Bredt, D. S., & Becker, L. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.657 · Cited by 480

Nitric oxide and atherosclerosis: An update

Claudio Napoli, A., de Nigris, F., Williams‐Ignarro, S., Pignalosa, O., Sica, V., & Ignarro, L. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.03.011 · Cited by 471

Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion

Gao, F., Gao, E., Yue, T.-L., Ohlstein, E. H., Lopez, B. L., Christopher, T. A., & Ma, X. (2002) · Circulation · doi:10.1161/01.cir.0000012529.00367.0f · Cited by 469

Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis

Kawashima, S., & Yokoyama, M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000125114.88079.96 · Cited by 455

Regulation of HIF-1α Stability through S-Nitrosylation

Li, F., Sonveaux, P., Rabbani, Z. N., Liu, S., Yan, B., Huang, Q., Vujašković, Ž., Dewhirst, M. W., & Li, C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.024 · Cited by 447

Shear Stress Stimulates Phosphorylation of Endothelial Nitric-oxide Synthase at Ser1179 by Akt-independent Mechanisms

Boo, Y. C., Sorescu, G. P., Boyd, N. L., Shiojima, I., Walsh, K., Du, J., & Jo, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108789200 · Cited by 447

Fundamentals of Reperfusion Injury for the Clinical Cardiologist

Verma, S., Fedak, P. W. M., Weisel, R. D., BUTANY, J. W., Rao, V., Maitland, A. M., Li, R., Dhillon, B., & Yau, T. M. (2002) · Circulation · doi:10.1161/01.cir.0000016602.96363.36 · Cited by 447

Oxidant stress from nitric oxide synthase–3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load

Takimoto, E., Champion, H. C., Li, M., Ren, S. V., Rodríguez, E. R., Tavazzi, B., Lazzarino, G., Paolocci, N., Gabrielson, K. L., Wang, Y., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21968 · Cited by 446

Mechanotransduction and the glycocalyx

Tarbell, J. M., & Pahakis, M. Y. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01620.x · Cited by 437

Effect of Endothelial Shear Stress on the Progression of Coronary Artery Disease, Vascular Remodeling, and In-Stent Restenosis in Humans

Stone, P. H., Coskun, A. U., Kinlay, S., Clark, M. E., Milan Sonka, A., Wahle, A., Ilegbusi, O. J., Yeghiazarians, Y., Popma, J. J., Orav, E. J., et al. (2003) · Circulation · doi:10.1161/01.cir.0000080882.35274.ad · Cited by 435

Transcriptional and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide

Drummond, G. R., Cai, H., Davis, M. E., Ramasamy, S., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.86.3.347 · Cited by 430

Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase

Landmesser, U., Engberding, N., Bahlmann, F. H., Schaefer, A., Wiencke, A., Heineke, A., Spiekermann, S., Hilfiker‐Kleiner, D., Templin, C., Kotlarz, D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000143232.67642.7a · Cited by 423

Fluid Shear Stress Activation of Focal Adhesion Kinase

Li, S., Kim, M. S., Hu, Y., Jalali, S., Schlaepfer, D. D., Hunter, T. R., Chien, S., & Shyy, J. Y.-J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30455 · Cited by 419

High Glucose Causes Upregulation of Cyclooxygenase-2 and Alters Prostanoid Profile in Human Endothelial Cells

Cosentino, F., Eto, M., Paolis, P. D., van der Loo, B., Bachschmid, M. M., Ullrich, V., Kouroedov, A., Gatti, C., Joch, H., Volpe, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000051367.92927.07 · Cited by 419

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

Jalali, S., del Pozo, M. Á., Chen, K., Miao, H., Li, Y.-S. J., Schwartz, M. A., Shyy, J. Y.-J., & Chien, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1042 · Cited by 417

Estrogen Receptor α and Endothelial Nitric Oxide Synthase Are Organized Into a Functional Signaling Module in Caveolae

Chambliss, K. L., Yuhanna, I. S., Mineo, C., Liu, P., German, Z., Sherman, T. S., Mendelsohn, M. E., Anderson, R. G. W., & Shaul, P. W. (2000) · Circulation Research · doi:10.1161/01.res.87.11.e44 · Cited by 416

Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

Metzen, E., Zhou, J., Jelkmann, W., Fandrey, J., & Brüne, B. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-12-0791 · Cited by 414

Disruption of methylarginine metabolism impairs vascular homeostasis

LEIPER, J. M., Nandi, M., Torondel, B., Murray‐Rust, J., Malaki, M., O'Hara, B. P., Rossiter, S., Anthony, S., Madhani, M., Selwood, D. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1543 · Cited by 408

Cellular targets and mechanisms of nitros(yl)ation: An insight into their nature and kinetics in vivo

Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400

Life history of eNOS: partners and pathways

DUDZINSKI, D., & MICHEL, T. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.023 · Cited by 400

Vascular Endothelial Growth Factor/Vascular Permeability Factor Augments Nitric Oxide Release From Quiescent Rabbit and Human Vascular Endothelium

van der Zee, R., Murohara, T., Luo, Z., Zollmann, F. S., Passeri, J. J., Lekutat, C., & Isner, J. M. (1997) · Circulation · doi:10.1161/01.cir.95.4.1030 · Cited by 399

The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress

Pahakis, M. Y., Kosky, J. R., Dull, R. O., & Tarbell, J. M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.137 · Cited by 391

Enhanced Electron Flux and Reduced Calmodulin Dissociation May Explain “Calcium-independent” eNOS Activation by Phosphorylation

McCabe, T. J., Fulton, D., Roman, L. J., & Sessa, W. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6123 · Cited by 387 · cited 14×

Hormonal Treatment of Postmenopausal Women

Wood, A. J. J., & Belchetz, P. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301508 · Cited by 386

Endothelial cellular response to altered shear stress

Fisher, A. B., Chien, S., Barakat, A. I., & Nerem, R. M. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.3.l529 · Cited by 384

Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels

Yu, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27100 · Cited by 384

Ligand-Independent Activation of Vascular Endothelial Growth Factor Receptor 2 by Fluid Shear Stress Regulates Activation of Endothelial Nitric Oxide Synthase

Jin, Z., Ueba, H., Tanimoto, T., Lungu, A. O., Frame, M. D. S., & Berk, B. C. (2003) · Circulation Research · doi:10.1161/01.res.0000089257.94002.96 · Cited by 380

Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy?

Kojda, G., & Hambrecht, R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.032 · Cited by 378

8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.

Shah, A. M., Spurgeon, H. A., Sollott, S. J., Talo, A., & Lakatta, E. G. (1994) · Circulation Research · doi:10.1161/01.res.74.5.970 · Cited by 377

Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion.

Paulus, W. J., Vantrimpont, P. J. M. J., & Shah, A. M. (1994) · Circulation · doi:10.1161/01.cir.89.5.2070 · Cited by 367

Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia

Adams, V., Lenk, K., Linke, A., Lenz, D., Erbs, S., Sandri, M., Tarnok, A., Gielen, S., Emmrich, F., Schuler, G., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000124104.23702.a0 · Cited by 367

Mitochondria as signaling organelles in the vascular endothelium

Quintero, M., Colombo, S. L., Godfrey, A. R., & Moncada, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601026103 · Cited by 362

The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle

Féron, O., Saldaña, F., Michel, J. B., & Michel, T. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3125 · Cited by 361

Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade.

Ohno, M., Cooke, J. P., Dzau, V. J., & Gibbons, G. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117787 · Cited by 359

Endothelial KLF2 Links Local Arterial Shear Stress Levels to the Expression of Vascular Tone-Regulating Genes

Dekker, R. J., van Thienen, J. V., Rohlena, J., de Jager, S. C. A., Elderkamp, Y. W., Seppen, J., de Vries, C. J. M., Biessen, E. A. L., van Berkel, T. J. C., Pannekoek, H., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63002-7 · Cited by 355

Caveolin-3 Associates with Developing T-tubules during Muscle Differentiation

Parton, R. G., Way, M., Zorzi, N., & Stang, E. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.1.137 · Cited by 354

Evidence for a Functional Role of Endothelial Transient Receptor Potential V4 in Shear Stress–Induced Vasodilatation

Köhler, R., Heyken, W., Heinau, P., Schubert, R., Si, H., Kacik, M., Busch, C., Grgic, I., Maier, T., & Hoyer, J. D. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000225698.36212.6a · Cited by 346

Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells

Shen, J., Luscinskas, F. W., Connolly, A. J., Dewey, C. F., & Gimbrone, M. A. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.2.c384 · Cited by 346

Up‐regulation of nitric oxide synthase by estradiol in human aorticendothelial cells

Hishikawa, K., Nakaki, T., Marumo, T., Suzuki, H., Kato, R., & Saruta, T. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00124-r · Cited by 341

Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis

Dayoub, H., Achan, V., Adimoolam, S., Jacobi, J., Stuehlinger, M. C., Wang, B., Tsao, P. S., Kimoto, M., Vallance, P. J., Patterson, A. J., et al. (2003) · Circulation · doi:10.1161/01.cir.0000101924.04515.2e · Cited by 340

Domain Mapping Studies Reveal That the M Domain of hsp90 Serves as a Molecular Scaffold to Regulate Akt-Dependent Phosphorylation of Endothelial Nitric Oxide Synthase and NO Release

Fontana, J. T., Fulton, D. J., Chen, Y., Fairchild, T. A., McCabe, T. J. D., Fujita, N., Tsuruo, T., & Sessa, W. C. (2002) · Circulation Research · doi:10.1161/01.res.0000016837.26733.be · Cited by 340

VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E., & Resnick, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142224299 · Cited by 339

Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase

Pritchard, K. A., Ackerman, A. W., Gross, E. R., Stepp, D. W., Shi, Y., Fontana, J. T., Baker, J. E., & Sessa, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100084200 · Cited by 338

Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release

Mochizuki, S., Vink, H., Hiramatsu, O., Kajita, T., Shigeto, F., Spaan, J. A. E., & Kajiya, F. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00691.2002 · Cited by 332

Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes

Petroff, M. V., Kim, S. H., Pepe, S., Dessy, C., Marbán, E., Balligand, J., & Sollott, S. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1001-867 · Cited by 328

Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells

Fleming, I., Fißlthaler, B., Dixit, M., & Busse, R. (2005) · Journal of Cell Science · doi:10.1242/jcs.02541 · Cited by 328

Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells.

Awolesi, M. A., Sessa, W. C., & Sumpio, B. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118181 · Cited by 328

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

Ido, Y., Carling, D., & Ruderman, N. B. (2002) · Diabetes · doi:10.2337/diabetes.51.1.159 · Cited by 323

Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression

Alp, N. J., Mussa, S., Khoo, J. P., Cai, S., Guzik, T. J., Jefferson, A., Goh, N., Rockett, K. A., & Channon, K. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17786 · Cited by 322

Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways

Davis, M. E., Cai, H. “., Drummond, G. R., & Harrison, D. G. (2001) · Circulation Research · doi:10.1161/hh2301.100806 · Cited by 310

Gene Transfer of Stromal Cell–Derived Factor-1α Enhances Ischemic Vasculogenesis and Angiogenesis via Vascular Endothelial Growth Factor/Endothelial Nitric Oxide Synthase–Related Pathway

Hiasa, K., Ishibashi, M., Ohtani, K., Inoue, S., Zhao, Q. D., Kitamoto, S., Sata, M., Ichiki, T., Takeshita, A., & Egashira, K. (2004) · Circulation · doi:10.1161/01.cir.0000128213.96779.61 · Cited by 308

Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress

Fisslthaler, Dimmeler, S., Hermann, Busse, & Fleming (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00627.x · Cited by 308

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction

Osawa, M., Masuda, M., Kusano, K.-I., & Fujiwara, K. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205049 · Cited by 307

In Situ Flow Activates Endothelial Nitric Oxide Synthase in Luminal Caveolae of Endothelium with Rapid Caveolin Dissociation and Calmodulin Association

Rizzo, V., McIntosh, D. P., Oh, P., & Schnitzer, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.34724 · Cited by 306

Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs.

Wang, J., Wolin, M. S., & Hintze, T. H. (1993) · Circulation Research · doi:10.1161/01.res.73.5.829 · Cited by 304

Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia

Stuehlinger, M., Oka, R. K., Graf, E. E., Schmoelzer, I., Upson, B. M., Kapoor, O., Szuba, A., Malinow, M. R., Wascher, T. C., Pachinger, O. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000085067.55901.89 · Cited by 303

Hemodynamics and atherosclerosis1

Stehbens, W. E. (1982) · Biorheology · doi:10.3233/bir-1982-191-210 · Cited by 303

Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity

Rivard, A., Berthou-Soulié, L., Principe, N., Kearney, M., Curry, C., Branellec, D., Semenza, G. L., & Isner, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001029200 · Cited by 301

Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., Acetis, M. D., Vecchione, C., Marino, G., Altruda, F., et al. (2002) · Nature Medicine · doi:10.1038/nm805 · Cited by 295

Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress

Ranjan, V., Xiao, Z., & Diamond, S. L. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.2.h550 · Cited by 294

Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase

Garcin, E. D., Bruns, C. M., Lloyd, S. J., Hosfield, D. J., Tiso, M., Gachhui, R., Stuehr, D. J., Tainer, J. A., & Getzoff, E. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406204200 · Cited by 293

Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice.

Krzysztof Reiss, F., Cheng, W. N., Ferbér, A., Kajstura, J., Li, P., Li, B., Olivetti, G., Homcy, C. J., Baserga, R., & Anversa, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8630 · Cited by 292

Protection from Experimental Asthma by an Endogenous Bronchodilator

Que, L. G., Liu, L., Yan, Y., Whitehead, G. S., Gavett, S. H., Schwartz, D. A., & Stamler, J. S. (2005) · Science · doi:10.1126/science.1108228 · Cited by 289

The subendothelial extracellular matrix modulates NF-κB activation by flow

Orr, A. W., Sanders, J. M., Bevard, M. H., Coleman, E. J., Sarembock, I. J., & Schwartz, M. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410073 · Cited by 289

S -nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

LEIPER, J. M., Murray‐Rust, J., McDonald, N. Q., & Vallance, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212269799 · Cited by 288

Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Shear Stress Response

Tzima, E. (2006) · Circulation Research · doi:10.1161/01.res.0000200162.94463.d7 · Cited by 286

Endothelial Nitric-oxide Synthase (Type III) Is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases

Butt, E., Bernhardt, M., Smolenski, A., Kotsonis, P., Fröhlich, L. G., Sickmann, A., Meyer, H. E., Lohmann, S. M., & Schmidt, H. H. H. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5179 · Cited by 284

Myocardial Contractile Response to Nitric Oxide and cGMP

Mohan, P., Brutsaert, D. L., Paulus, W. J., & Sys, S. U. (1996) · Circulation · doi:10.1161/01.cir.93.6.1223 · Cited by 281

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells

Li, S., Butler, P. J., Wang, Y., Hu, Y., Han, D. C., Usami, S., Guan, J., & Chien, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052018099 · Cited by 276

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

Fiedler, B., Lohmann, S. M., Smolenski, A., Linnemüller, S., Pieske, B. M., Schröder, F., Molkentin, J. D., Drexler, H., & Wollert, K. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162100799 · Cited by 276

Endogenous and Exogenous Nitric Oxide Inhibits Norepinephrine Release From Rat Heart Sympathetic Nerves

Schwarz, P., Diem, R., Dun, N. J., & Förstermann, U. (1995) · Circulation Research · doi:10.1161/01.res.77.4.841 · Cited by 275

Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique

Cheng, C., van Haperen, R., de Waard, M., van Damme, L. C. A., Tempel, D., Hanemaaijer, L., van Cappellen, G. W. A., Bos, J., Slager, C. J., Duncker, D. J., et al. (2005) · Blood · doi:10.1182/blood-2005-06-2326 · Cited by 274

Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation

Hambrecht, R., Hilbrich, L., Erbs, S., Gielen, S., Fiehn, E., Schoene, N., & Schuler, G. C. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00602-6 · Cited by 272

S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity

Ravi, K., Brennan, L., Levic, S., Ross, P. A., & Black, S. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0300464101 · Cited by 268

Hsp90 and Caveolin Are Key Targets for the Proangiogenic Nitric Oxide–Mediated Effects of Statins

Brouet, A., Sonveaux, P., Dessy, C., Moniotte, S., Balligand, J., & Féron, O. (2001) · Circulation Research · doi:10.1161/hh2201.100319 · Cited by 268

Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor α

Lu, Q. R., Pallas, D. C., Surks, H. K., Baur, W. E., Mendelsohn, M. E., & Karas, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407492101 · Cited by 266

Circulating Nitric Oxide (Nitrite/Nitrate) Levels in Postmenopausal Women Substituted With 17β-Estradiol and Norethisterone Acetate

Rosselli, M., Imthurn, B., Keller, P. J., Jackson, E. K., & Dubey, R. K. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.848 · Cited by 264

Nitric Oxide Synthases and Cardiac Muscle

Balligand, J., & Cannon, P. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.1846 · Cited by 263

Accumulation of HIF-1α under the influence of nitric oxide

Sandau, K. B., Fandrey, J., & Brüne, B. (2001) · Blood · doi:10.1182/blood.v97.4.1009 · Cited by 263

Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.

Ohno, M., Gibbons, G. H., Dzau, V. J., & Cooke, J. P. (1993) · Circulation · doi:10.1161/01.cir.88.1.193 · Cited by 261

Effects of damaging the endocardial surface on the mechanical performance of isolated cardiac muscle.

Brutsaert, D. L., Meulemans, A., Sipido, K. R., & Sys, S. U. (1988) · Circulation Research · doi:10.1161/01.res.62.2.358 · Cited by 260

Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed.

Lamontagne, D., Pohl, U., & Busse, R. (1992) · Circulation Research · doi:10.1161/01.res.70.1.123 · Cited by 252

Endogenous Cardiac Stem Cells

Barile, L., Messina, E., Giacomello, A., & Marbán, E. (2007) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.03.005 · Cited by 251

A Role for Endoglin in Coupling eNOS Activity and Regulating Vascular Tone Revealed in Hereditary Hemorrhagic Telangiectasia

Toporsian, M., Gros, R., Kabir, M. G., Vera, S., Govindaraju, K., Eidelman, D. H., Husain, M., & Letarte, M. (2005) · Circulation Research · doi:10.1161/01.res.0000159936.38601.22 · Cited by 249

Increased neuronal nitric oxide synthase-derived NO production in the failing human heart

Damy, T., Ratajczak, P., Shah, A. M., Camors, E. M., Marty, I., Hasenfuss, G. P., Marotte, F., Samuel, J., & Heymes, C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16048-0 · Cited by 247

Shear stress stimulates phosphorylation of eNOS at Ser635by a protein kinase A-dependent mechanism

Boo, Y. C., Hwang, J., Sykes, M. C., Michell, B. J., Kemp, B. E., Lum, H., & Jo, H. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00214.2002 · Cited by 240

Phosphorylation of Threonine 497 in Endothelial Nitric-oxide Synthase Coordinates the Coupling of l-Arginine Metabolism to Efficient Nitric Oxide Production

Lin, M. I., Fulton, D. J., Babbitt, R. W., Fleming, I., Busse, R., Pritchard, K. A., & Sessa, W. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302836200 · Cited by 239

The vimentin cytoskeleton regulates focal contact size and adhesion of endothelial cells subjected to shear stress

Tsuruta, D., & Jones, J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00823 · Cited by 239

Estrogens Increase Transcription of the Human Endothelial NO Synthase Gene

Kleinert, H., Wallerath, T., Euchenhofer, C., Ihrig‐Biedert, I., Li, H., & Förstermann, U. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.582 · Cited by 239

Cyclic Strain–Induced Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells Involves Reactive Oxygen Species Activation of Activator Protein 1

Wung, B., Cheng, J., Hsieh, H. J., Shyy, Y.-J., & Wang, D. L. (1997) · Circulation Research · doi:10.1161/01.res.81.1.1 · Cited by 235

Suppression of Endothelial Progenitor Cells in Human Coronary Artery Disease by the Endogenous Nitric Oxide Synthase Inhibitor Asymmetric Dimethylarginine

Thum, T., Tsikas, D., Stein, S., Schultheiß, M., Eigenthaler, M., Anker, S. D., Poole-Wilson, P. A., Ertl, G., & Bauersachs, J. K. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.066 · Cited by 234

EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries

Pohl, U., Herlan, K., Huang, A., & Bassenge, E. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.6.h2016 · Cited by 234

Mechanical Transduction of Nitric Oxide Synthesis in the Beating Heart

Pinsky, D. J., Patton, S. R., Mesároš, Š., Brovkovych, V. M., Kubaszewski, E., Grunfeld, S., & Maliñski, T. (1997) · Circulation Research · doi:10.1161/01.res.81.3.372 · Cited by 233

IDENTIFICATION OF BLOOD PRESSURE CONTROL MECHANISMS BY POWER SPECTRAL ANALYSIS

Stauss, H. M. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04588.x · Cited by 231

Cardiomyocyte-Specific Overexpression of Nitric Oxide Synthase 3 Improves Left Ventricular Performance and Reduces Compensatory Hypertrophy After Myocardial Infarction

Janssens, S. P., Pokreisz, P., Schoonjans, L., Pellens, M., Vermeersch, P., Tjwa, M., Jans, P., Scherrer‐Crosbie, M., Picard, M. H., Szelid, Z., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000126497.38281.23 · Cited by 231

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

Li, Y.-S. J., Shyy, J. Y.-J., Li, S., Lee, J., Su, B., Karin, M., & Chien, S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.5947 · Cited by 230

Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta

Delp, M. D., McAllister, R. M., & Laughlin, M. H. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1354 · Cited by 227

Role of cyclic GMP‐dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes

Layland, J., Li, J., & Shah, A. M. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.014126 · Cited by 223

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice

Hauser, W., Knobeloch, K., Eigenthaler, M., Gambaryan, S. P., Krenn, V., Geiger, J., Glazova, M. V., Rohde, E., Horak, I. D., Walter, U., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8120 · Cited by 222

Angiogenesis and Vasculogenesis Are Impaired in the Precocious-Aging klotho Mouse

Shimada, T., Takeshita, Y., Murohara, T., Sasaki, K., Egami, K., Shintani, S., Katsuda, Y., Ikeda, H., Nabeshima, Y., & Imaizumi, T. (2004) · Circulation · doi:10.1161/01.cir.0000139854.74847.99 · Cited by 221

Regulation of Bone Morphogenetic Protein-2 Expression in Endothelial Cells

Csiszár, A., Smith, K. E., Koller, Á., Kaley, G., Edwards, J. G., & Ungvari, Z. I. (2005) · Circulation · doi:10.1161/01.cir.0000164201.40634.1d · Cited by 218

Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro

Rizzo, V., Morton, C. A., DePaola, N., Schnitzer, J. E., & Davies, P. F. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00344.2002 · Cited by 218

Caveolin-1 Expression Is Critical for Vascular Endothelial Growth Factor–Induced Ischemic Hindlimb Collateralization and Nitric Oxide–Mediated Angiogenesis

Sonveaux, P., Martinive, P., DeWever, J., Batova, Z., Daneau, G., Pelat, M., Ghisdal, P., Grégoire, V., Dessy, C., Balligand, J., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000136344.27825.72 · Cited by 218

Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.

Murray‐Rust, J., LEIPER, J. M., McAlister, M. S. B., Phelan, J. P., Tilley, S. J., MARIA, J. S., Vallance, P. J., & McDonald, N. Q. (2001) · Nature Structural Biology · doi:10.1038/90387 · Cited by 217

Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism.

Laurindo, F. R. M., Pedro, M. D. A., Barbeiro, H. V., Pileggi, F., de Carvalho, M. H. C., Augusto, O., & da Luz, P. L. (1994) · Circulation Research · doi:10.1161/01.res.74.4.700 · Cited by 215

Estradiol Alters Nitric Oxide Production in the Mouse Aorta Through the α-, but not β-, Estrogen Receptor

Darblade, B., Pendaries, C., Krust, A., Dupont, S., Fouque, M.-J., RAMI, J., Chambon, P., Bayard, F., & Arnal, J. (2002) · Circulation Research · doi:10.1161/hh0402.105096 · Cited by 214

Hsp90 Ensures the Transition from the Early Ca2+-dependent to the Late Phosphorylation-dependent Activation of the Endothelial Nitric-oxide Synthase in Vascular Endothelial Growth Factor-exposed Endothelial Cells

Brouet, A., Sonveaux, P., Dessy, C., Balligand, J., & Féron, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101371200 · Cited by 213

Shear Stress Regulates Endothelial Nitric-oxide Synthase Promoter Activity through Nuclear Factor κB Binding

Davis, M. E., Grumbach, I. M., Fukai, T., Cutchins, A. C., & Harrison, D. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307528200 · Cited by 213

Identification of Regulatory Sites of Phosphorylation of the Bovine Endothelial Nitric-oxide Synthase at Serine 617 and Serine 635

Michell, B. J., Harris, M. B., Chen, Z.-P., Ju, H., Venema, V. J., Blackstone, M. A., Huang, W., Venema, R. C., & Kemp, B. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205144200 · Cited by 212

AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress

Zhang, Y., Lee, T.-S., Kolb, E. M., Sun, K., Lu, X., Sladek, F. M., Kassab, G. S., Garland, T., & Shyy, J. Y.-J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000221230.08596.98 · Cited by 212 · cited 1×

Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of Bone Marrow–Derived Endothelial Progenitor Cells Into Sites of Ischemia-Induced Neovascularization via Endothelial Nitric Oxide Synthase–Mediated Activation of Matrix Metalloproteinase-9

Iwakura, A., Shastry, S., Luedemann, C., Hamada, H., Kawamoto, A., Kishore, R., Zhu, Y., Qin, G., Silver, M., Thorne, T., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.553925 · Cited by 211

VEGF Induces Nuclear Translocation of Flk-1/KDR, Endothelial Nitric Oxide Synthase, and Caveolin-1 in Vascular Endothelial Cells

Feng, Y., Venema, V. J., Venema, R. C., Tsai, N., & Caldwell, R. B. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9790 · Cited by 210

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

Incalza, M. A., D’Oria, R., Natalicchio, A., Perrini, S., Laviola, L., & Giorgino, F. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.05.005 · Cited by 1,419

Piezo1 integration of vascular architecture with physiological force

Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,250

Nitric oxide signalling in cardiovascular health and disease

Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

Wang, S., Chennupati, R., Kaur, H., Iring, A., Wettschureck, N., & Offermanns, S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87343 · Cited by 616

Dessy C. eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol Rev

Balligand, J., Féron, O., & Dessy, C. (2016)

Nitric Oxide Synthase Expression in Endothelial Cells Exposed to Mechanical Forces

Ziegler, T., Silacci, P., Harrison, V. J., & Hayoz, D. (1998) · Hypertension · doi:10.1161/01.hyp.32.2.351 · Cited by 239

Role of Nitric Oxide in the Regulation of Blood Flow

Griffith, T. M. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50032-0 · Cited by 8

Molecular mechanisms underlying the activation of eNOS

Fleming, I. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0767-7 · Cited by 437

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591