The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control
Open accessAbstract
The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy conditions, they limit the excitability of spinal terminals of primary sensory nerve fibers and of intrinsic dorsal horn neurons through pre- and postsynaptic mechanisms, and thereby facilitate the spatial and temporal discrimination of sensory stimuli. Removal of fast inhibition not only reduces the fidelity of normal sensory processing but also provokes symptoms very much reminiscent of pathological and chronic pain syndromes. This review summarizes our knowledge of the molecular bases of spinal inhibitory neurotransmission and its organization in dorsal horn sensory circuits. Particular emphasis is placed on the role and mechanisms of spinal inhibitory malfunction in inflammatory and neuropathic chronic pain syndromes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
Opioid-induced Hyperalgesia: A Qualitative Systematic Review
Angst, M. S., & Clark, J. D. (2006) · Anesthesiology · doi:10.1097/00000542-200603000-00025 · Cited by 1,188
Neurosteroids: endogenous regulators of the GABAA receptor
Belelli, D., & Lambert, J. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1703 · Cited by 1,159
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134
Coding of pleasant touch by unmyelinated afferents in humans
Löken, L. S., Wessberg, J., Morrison, I., McGlone, F., & Olausson, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2312 · Cited by 1,120
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007 · cited 1×
“Examples of the great potential of transcription factor-dependent cre expression in spinal interneuron populations are Pax2-cre (279) and Ptf1a-cre (188) mice.”
Molecular and neuronal substrate for the selective attenuation of anxiety
Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Rülicke, T., Bluethmann, H., Möhler, H., et al. (2000) · Science · doi:10.1126/science.290.5489.131 · Cited by 946
Application of a translational profiling approach for the comparative analysis of CNS cell types
Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.029 · Cited by 912
The development of nociceptive circuits
Fitzgerald, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1701 · Cited by 778
Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ
Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science · doi:10.1126/science.278.5336.279 · Cited by 690
Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin
Vallbo, Å. B., Olausson, H., & Wessberg, J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.2753 · Cited by 571
Reversal of pathological pain through specific spinal GABAA receptor subtypes
Knabl, J., Witschi, R., Hösl, K., Reinold, H., Zeilhofer, U. B., Ahmadi, S., Brockhaus, J., Sergejeva, M., Hess, A., Brune, K., et al. (2008) · Nature · doi:10.1038/nature06493 · Cited by 438 · cited 5×
“At first glance, the idea of GABA acting as an excitatory transmitter in neuropathic pain states seems to be at odds with the observation that facilitation of GABAA receptors by benzodiazepines, under these conditions, produces antihyperalgesic effects (196, 200).”
InfluentialSelf-citationAnalysis of the set of GABAA receptor genes in the human genome
Simon, J., Wakimoto, H., Fujita, N., Lalande, M., & Barnard, E. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401354200 · Cited by 253
γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
Braun, M., Ramracheya, R., Bengtsson, M., Clark, A., Walker, J. N., Johnson, P. R., & Rorsman, P. (2010) · Diabetes · doi:10.2337/db09-0797 · Cited by 239
Developmental switch from GABA to glycine release in single central synaptic terminals
Nabekura, J., Katsurabayashi, S., Kakazu, Y., Shibata, S., Matsubara, A., Jinno, S., Mizoguchi, Y., Sasaki, A., & Ishibashi, H. (2004) · Nature Neuroscience · doi:10.1038/nn1170 · Cited by 228 · cited 1×
“However, regional differences in the mechanism may still exist (271).”
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn
Glasgow, S. M., Henke, R. M., MacDonald, R. J., Wright, C. V. E., & Johnson, J. E. (2005) · Development · doi:10.1242/dev.02167 · Cited by 225
Naef, M., Curatolo, M., Petersen-Felix, S., Arendt-Nielsen, L., Zbinden, A., & Brenneisen, R. (2003) · Pain · doi:10.1016/s0304-3959(03)00163-5 · Cited by 209
Earnheart, J. C., Schweizer, C., Crestani, F., Iwasato, T., Itohara, S., Mohler, H., & Lüscher, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3609-06.2007 · Cited by 203
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
Reinold, H., Ahmadi, S., Depner, U. B., Layh, B., Heindl, C., Hamza, M., Pahl, A., Brune, K., Narumiya, S., Müller, U., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23618 · Cited by 202 · cited 4×
“This leads to production of the pronociceptive and proinflammatory PGE2 in the spinal cord (314, 330).”
InfluentialSelf-citationIdentification of two novel markers for alveolar epithelial type I and II cells
Chen, Z., Jin, N., Narasaraju, T., Chen, J., McFarland, L. R., Scott, M., & Liu, L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.048 · Cited by 87
Liang, Y., Huang, C., Hsu, K., & Takahashi, T. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.056986 · Cited by 42
Cited by
Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.003 · Cited by 582
Neural circuits for pain: Recent advances and current views
Peirs, C., & Seal, R. P. (2016) · Science · doi:10.1126/science.aaf8933 · Cited by 478
Braz, J., Solorzano, C., Wang, X., & Basbaum, A. I. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.018 · Cited by 447
Orefice, L. L., Zimmerman, A. L., Chirila, A. M., Sleboda, S. J., Head, J. P., & Ginty, D. D. (2016) · Cell · doi:10.1016/j.cell.2016.05.033 · Cited by 383
Foster, E., Wildner, H., Tudeau, L., Haueter, S., Ralvenius, W. T., Jegen, M., Johannssen, H., Hösli, L., Haenraets, K., Ghanem, A., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.028 · Cited by 356
Self-citation
Metadata
- Authors
- Zeilhofer, H. U., Wildner, H., & Yévenes, G. E.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2012-01
- Volume
- 92
- Issue
- 1
- Pages
- 193-235
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2092629475
- Cited by
- 371
- References
- 21
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
