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Cited by 499

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Transporters for Cationic Amino Acids in Animal Cells: Discovery, Structure, and Function

DEVÉS, R., BOYD, C. A. R.·1998·Physiological Reviews
DOI 10.1152/physrev.1998.78.2.487
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Abstract

Devés, R., and C. A. R. Boyd. Transporters for Cationic Amino Acids in Animal Cells: Discovery, Structure, and Function. Physiol. Rev. 78: 487–545, 1998. — The structure and function of the four cationic amino acid transporters identified in animal cells are discussed. The systems differ in specificity, cation dependence, and physiological role. One of them, system y+, is selective for cationic amino acids, whereas the others (B 0,+, b 0,+, and y+L) also accept neutral amino acids. In recent years, cDNA clones related to these activities have been isolated. Thus two families of proteins have been identified: 1) CAT or cationic amino acid transporters and 2) BAT or broad-scope transport proteins. In the CAT family, three genes encode for four different isoforms [CAT-1, CAT-2A, CAT-2(B) and CAT-3]; these are ∼70-kDa proteins with multiple transmembrane segments ( 12 – 14 ), and despite their structural similarity, they differ in tissue distribution, kinetics, and regulatory properties. System y+is the expression of the activity of CAT transporters. The BAT family includes two isoforms (rBAT and 4F2hc); these are 59- to 78-kDa proteins with one to four membrane-spanning segments, and it has been proposed that these proteins act as transport regulators. The expression of rBAT and 4F2hc induces system b 0,+and system y+L activity in Xenopus laevis oocytes, respectively. The roles of these transporters in nutrition, endocrinology, nitric oxide biology, and immunology, as well as in the genetic diseases cystinuria and lysinuric protein intolerance, are reviewed. Experimental strategies, which can be used in the kinetic characterization of coexpressed transporters, are also discussed.

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Metadata

Authors
DEVÉS, R., & BOYD, C. A. R.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
1998-04-01
Volume
78
Issue
2
Pages
487-545
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.1998.78.2.487
OpenAlex
W1927805387
Cited by
499
References
1
FWCI
2.23
Type
journal article
Language
en
Open access
closed

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