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Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis
Open accessAbstract
Endometriosis, defined as the presence of endometrial tissue outside the uterus, is a common gynecological disease with poorly understood pathogenesis. MicroRNAs are members of a class of small noncoding RNA molecules that have a critical role in posttranscriptional regulation of gene expression by repression of target mRNAs translation. We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium in 3 patients through microarray analysis. We identified 50 microRNAs differentially expressed and the differential expression of five microRNAs was validated by real-time RT-PCR in other 13 patients. We identified in silico their predicted targets, several of which match the genes that have been identified to be differentially expressed in ectopic versus eutopic endometrium in studies of gene expression. A functional analysis of the predicted targets indicates that several of these are involved in molecular pathways implicated in endometriosis, thus strengthening the hypothesis of the role of microRNAs in this pathology.
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“Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups [120–124].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [122]
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“Similar to peritoneal disease, ovarian endometriosis evidenced differential expression of miRNAs relative to paired eutopic endometrium in several studies [122, 123].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [122]
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Metadata
- Authors
- Filigheddu, N., Gregnanin, I., Porporato, P. E., Surico, D., Perego, B., Galli, L., Patrignani, C., Graziani, A., & Surico, N.
- Affiliations
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Corresponding author
- Filigheddu, Nicoletta
- ORCID
- Venue
- Journal of Biomedicine and Biotechnology
- Publisher
- Hindawi Limited
- Published
- 2010
- Volume
- 2010
- Pages
- 1-29
- ISSN
- 1110-7243 (ISSN-L)
- 1110-7251
- PMC
- PMC2837904
- OpenAlex
- W2044038984
- Cited by
- 162
- References
- 63
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 13 · 2012: 8
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- endometrioma, microRNA, ectopic endometrium, eutopic endometrium, differential gene expression, post-transcriptional regulation, miRNA target prediction, endometriosis pathogenesis
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Middle Aged, Ovarian Diseases, Gene Expression, MicroRNAs
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