The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Shift Work, Jet Lag, and Female Reproduction
Open accessAbstract
Circadian rhythms and “clock gene” expression are involved in successful reproductive cycles, mating, and pregnancy. Alterations or disruptions of biological rhythms, as commonly occurs in shift work, jet lag, sleep deprivation, or clock gene knock out models, are linked to significant disruptions in reproductive function. These impairments include altered hormonal secretion patterns, reduced conception rates, increased miscarriage rates and an increased risk of breast cancer. Female health may be particularly susceptible to the impact of desynchronizing work schedules as perturbed hormonal rhythms can further influence the expression patterns of clock genes. Estrogen modifies clock gene expression in the uterus, ovaries, and suprachiasmatic nucleus, the site of the primary circadian clock mechanism. Further work investigating clock genes, light exposure, ovarian hormones, and reproductive function will be critical for indentifying how these factors interact to impact health and susceptibility to disease.
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“Epidemiological studies report increased risks of preterm delivery, low birthweights and miscarriage in pregnant women who are chronic shift-workers37–40.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [40]
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Cites
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Cited by
Sorted by citations
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713
Shift work and the assessment and management of shift work disorder (SWD)
Wright, K. P., Bogan, R. K., & Wyatt, J. K. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.02.002 · Cited by 437
Fatigue and its management in the workplace
Caldwell, J. A., Caldwell, J. L., Thompson, L., & Lieberman, H. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.024 · Cited by 444
Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology
Reiter, R. J., Tan, D. X., Korkmaz, A., & Rosales-Corral, S. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt054 · Cited by 371
Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease
Chitimus, D. M., Popescu, M. R., Voiculescu, S. E., Panaitescu, A. M., Pavel, B., Zagrean, L., & Zagrean, A.-M. (2020) · Biomolecules · doi:10.3390/biom10091211 · Cited by 354
Metadata
- Authors
- Mahoney, M. M.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Mahoney, Megan M.
- ORCID
- Mahoney, Megan M.
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-9
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC2834958
- OpenAlex
- W2092516139
- Cited by
- 209
- References
- 98
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 13 · 2023: 19 · 2022: 10 · 2021: 15 · 2020: 19 · 2019: 19 · 2018: 17 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 14 · 2012: 12
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- shift work, jet lag, female reproduction, circadian rhythm, clock genes, reproductive hormones, estrogen, suprachiasmatic nucleus, sleep deprivation, miscarriage, breast cancer risk, ovarian hormones, light exposure
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