The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Rodent Models for Metabolic Syndrome Research
Open accessAbstract
Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet‐induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat‐fed male rodent.
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Cites
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“Control” laboratory rodents are metabolically morbid: Why it matters
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Cited by
High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation
Dutheil, S., Ota, K. T., Wohleb, E. S., Rasmussen, K., & Duman, R. S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.357 · Cited by 355
Lindholm, C. R., Ertel, R. L., Bauwens, J. D., Schmuck, E. G., Mulligan, J. D., & Saupe, K. W. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0199-2 · Cited by 136
Hypogonadism and metabolic syndrome.
(2011) · PubMed · doi:10.3275/7806 · Cited by 125
Cordero, P., Milagro, F. I., Campion, J., & Martinez, J. A. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s204017441400035x · Cited by 45
Buniam, J., Chukijrungroat, N., Rattanavichit, Y., Surapongchai, J., Weerachayaphorn, J., Bupha-Intr, T., & Saengsirisuwan, V. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02936-1 · Cited by 35
Metadata
- Authors
- Panchal, S. K., & Brown, L.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2010-12-30
- Volume
- 2011
- Issue
- 1
- Pages
- 351982-351982
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2060294481
- Cited by
- 408
- References
- 8
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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