Cited by 356Diet, Metabolism, and DiseaseRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

“Control” laboratory rodents are metabolically morbid: Why it matters

Open access
Martin, Bronwen, Ji, Sunggoan, Maudsley, Stuart, Mattson, Mark P.·2010·Proceedings of the National Academy of Sciences

Abstract

Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects.

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Crossref · 10.1073/pnas.0912955107

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109 of 109 references verified0 citation errors · 0 not checkable

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  • Physical fitness and activity status, along with genetic makeup, influence how well drugs work.

    “The efficacy of drugs is affected by physical fitness/activity status (104, 328) in addition to genetic disposition.”

    From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [328]

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Authors
Martin, B., Ji, S., Maudsley, S., & Mattson, M. P.
Affiliations
  • National Institute on Aging (US)
  • National Institutes of Health (US)
Venue
Proceedings of the National Academy of Sciences
Published
2010-03
Volume
107
Issue
14
Pages
6127-6133
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2081308389
Cited by
354
References
109
Citations by year
2026: 10 · 2025: 11 · 2024: 22 · 2023: 14 · 2022: 20 · 2021: 17 · 2020: 19 · 2019: 35 · 2018: 19 · 2017: 18 · 2016: 20 · 2015: 18 · 2014: 35 · 2013: 19 · 2012: 36
FWCI
23.17
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
laboratory rodents, sedentary behavior, obesity, impaired glucose tolerance, metabolic disorders, oxidative stress, inflammation, physical activity, energy intake, animal models of human disease, premature mortality
MeSH terms
Animals, Body Weight, Obesity, Morbid, Physical Conditioning, Animal, Models, Animal, Caloric Restriction, Mice, Rats

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