A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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AMPK and the biochemistry of exercise: implications for human health and disease

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Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

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Rodent Models for Metabolic Syndrome Research

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AMPK inhibition in health and disease

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Sensing of energy and nutrients by AMP-activated protein kinase

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Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

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AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues

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AMPK as a mediator of hormonal signalling

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AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.

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Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK

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Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle

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Leptin resistance: a prediposing factor for diet-induced obesity

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Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

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Interleukin-6 Regulation of AMP-Activated Protein Kinase

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Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle

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AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

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The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation

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Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

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Functional Adiponectin Resistance at the Level of the Skeletal Muscle in Mild to Moderate Chronic Heart Failure

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Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition

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Inflammation in Obesity is a Common Link Between Defects in Fatty Acid Metabolism and Insulin Resistance

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Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance

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High-fat diet feeding impairs both the expression and activity of AMPKa in rats’ skeletal muscle

Liu, Y., Wan, Q., Guan, Q., Gao, L., & Zhao, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.068 · Cited by 136 · see citing works

Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats

Kraegen, E. W., Saha, A. K., Preston, E., Wilks, D. L., Hoy, A. J., Cooney, G. J., & Ruderman, N. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00316.2005 · Cited by 124 · see citing works

Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity

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Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice

Fujii, N., Ho, R. C., Manabe, Y., Jessen, N., Toyoda, T., Holland, W. L., Summers, S. A., Hirshman, M. F., & Goodyear, L. J. (2008) · Diabetes · doi:10.2337/db07-1187 · Cited by 107 · see citing works

Getting away from glucose: fanning the flames of obesity-induced inflammation

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Effect of a High‐fat Diet on 24‐Hour Pattern of Circulating Adipocytokines in Rats

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Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice

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Insulin resistance and fuel homeostasis: the role of AMP‐activated protein kinase

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Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation

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Are there specific treatments for the metabolic syndrome?

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Anti-obesity Effects of Juniperus chinensis Extract Are Associated with Increased AMP-Activated Protein Kinase Expression and Phosphorylation in the Visceral Adipose Tissue of Rats

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Aging Elevates Basal Adenosine Monophosphate-Activated Protein Kinase (AMPK) Activity and Eliminates Hypoxic Activation of AMPK in Mouse Liver

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Effect of Dietary Fat Intake and Exercise on Inflammatory Mediators of the Immune System in Sedentary Men and Women

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Unaltered TNF-alpha production by macrophages and monocytes in diet-induced obesity in the rat.

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AMPK as Target for Intervention in Childhood and Adolescent Obesity

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Role of AMP-activated Protein Kinase and Adiponectin during Development of Hepatic Steatosis in High-fat Diet-induced Obesity in Rats

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Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner

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Effects of Dietary Lactose on Long‐term High‐fat‐diet‐induced Obesity in Rats

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AMPK as a Therapeutic Target for Treating Metabolic Diseases

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Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis

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Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

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Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

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AMPK, Mitochondrial Function, and Cardiovascular Disease

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Obesity May Accelerate the Aging Process

Salvestrini, V., Sell, C., & Lorenzini, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00266 · Cited by 260 · see citing works

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo

Foretz, M., Even, P. C., & Viollet, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092826 · Cited by 177 · see citing works

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

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Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK

Fu, X., Zhu, M., Zhang, S., Foretz, M., Viollet, B., & Du, M. (2016) · Diabetes · doi:10.2337/db15-0647 · Cited by 155 · see citing works

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4 + T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals

Mauro, C., Smith, J., Cucchi, D., Coe, D., Fu, H., Bonacina, F., Baragetti, A., Cermenati, G., Caruso, D., Mitro, N., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.008 · Cited by 149 · see citing works

Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid

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High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

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Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway

Xi, Y., Wu, M., Li, H., Dong, S., Luo, E., Gu, M., Shen, X. Z., Jiang, Y., Liu, Y., & Liu, H. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000374037 · Cited by 110 · see citing works

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

Galić, S., Loh, K., Murray‐Segal, L., Steinberg, G. R., Andrews, Z. B., & Kemp, B. E. (2018) · eLife · doi:10.7554/elife.32656 · Cited by 108 · see citing works

The complex relationship between obesity and neurodegenerative diseases: an updated review

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Spirulina maxima Extract Reduces Obesity through Suppression of Adipogenesis and Activation of Browning in 3T3-L1 Cells and High-Fat Diet-Induced Obese Mice

Seo, Y., Kim, K., Choi, J., Koh, E., & Lee, B.-Y. (2018) · Nutrients · doi:10.3390/nu10060712 · Cited by 106 · see citing works

Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice

Ding, X., Jian, T., Li, J., Lv, H., Tong, B., Li, J., Meng, X., Ren, B., & Chen, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9734560 · Cited by 103 · see citing works

The Role of Butyrate, A Histone Deacetylase Inhibitor in Diabetes Mellitus: Experimental Evidence for Therapeutic Intervention

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Chia (Salvia hispanica L.) enhances HSP, PGC-1α expressions and improves glucose tolerance in diet-induced obese rats

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Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation

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Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies

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Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions

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Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1

Gaccioli, F., White, V., Capobianco, E., Powell, T. L., Jawerbaum, A., & Jansson, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109702 · Cited by 76 · see citing works

The ameliorative effect of probiotics on diet-induced lipid metabolism disorders: A review

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Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux

Hang, W., He, B., Chen, J., Xia, L., Wen, B., Liang, T., Wang, X., Zhang, Q., Wu, Y., Chen, Q., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01121 · Cited by 75 · see citing works

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

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RESEARCH ARTICLE Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet

Shiwa, M., Yoneda, M., Okubo, H., Ohno, H., Kobuke, K., Monzen, Y., Kishimoto, R., Nakatsu, Y., Asano, T., & Kohno, N. (2016)

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High-fat diet feeding impairs both the expression and activity of AMPKa in rats’ skeletal muscle

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