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Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions
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Glutathione (GSH) is a tripeptide, which has many biological roles including protection against reactive oxygen and nitrogen species. The primary goal of this paper is to characterize the principal mechanisms of the protective role of GSH against reactive species and electrophiles. The ancillary goals are to provide up-to-date knowledge of GSH biosynthesis, hydrolysis, and utilization; intracellular compartmentalization and interorgan transfer; elimination of endogenously produced toxicants; involvement in metal homeostasis; glutathione-related enzymes and their regulation; glutathionylation of sulfhydryls. Individual sections are devoted to the relationships between GSH homeostasis and pathologies as well as to developed research tools and pharmacological approaches to manipulating GSH levels. Special attention is paid to compounds mainly of a natural origin (phytochemicals) which affect GSH-related processes. The paper provides starting points for development of novel tools and provides a hypothesis for investigation of the physiology and biochemistry of glutathione with a focus on human and animal health.
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“The abundance of GSH is unusually high, the cytosol concentration is ca 1–11 mM, mitochondria contain 6–10 mM, and nuclei 3–15 mM of GSH.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Lushchak 2012
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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“Apart from the classical antioxidant role, GSH also has several organelle-specific functions discussed in detail by Lushchak (2012).”
Background
Metadata
- Authors
- Lushchak, V. I.
- Affiliations
- Vasyl Stefanyk Carpathian National University (UA)
- Corresponding author
- Lushchak, Volodymyr I.
- Venue
- Journal of Amino Acids
- Publisher
- Wiley
- Published
- 2012-02-28
- Volume
- 2012
- Pages
- 1-26
- ISSN
- 2090-0104 (ISSN-L)
- 2090-0112
- PMC
- PMC3303626
- OpenAlex
- W2043037824
- Cited by
- 1,266
- References
- 283
- Citations by year
- 2026: 70 · 2025: 117 · 2024: 119 · 2023: 126 · 2022: 125 · 2021: 131 · 2020: 110 · 2019: 79 · 2018: 76 · 2017: 93 · 2016: 64 · 2015: 64 · 2014: 52 · 2013: 29 · 2012: 7
- FWCI
- 20.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Amino Acids (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Education and Science of Ukraine (0106U002245)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- glutathione, glutathione homeostasis, reactive oxygen species, reactive nitrogen species, glutathione synthesis, glutathione metabolism, metal homeostasis, glutathionylation, sulfhydryl groups, phytochemicals, disease pathology
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