The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Glutathione in Detoxification of Reactive Oxygen Species and Methylglyoxal and in Heavy Metal Chelation
Open accessAbstract
Heavy metal (HM) toxicity is one of the major abiotic stresses leading to hazardous effects in plants. A common consequence of HM toxicity is the excessive accumulation of reactive oxygen species (ROS) and methylglyoxal (MG), both of which can cause peroxidation of lipids, oxidation of protein, inactivation of enzymes, DNA damage and/or interact with other vital constituents of plant cells. Higher plants have evolved a sophisticated antioxidant defense system and a glyoxalase system to scavenge ROS and MG. In addition, HMs that enter the cell may be sequestered by amino acids, organic acids, glutathione (GSH), or by specific metal-binding ligands. Being a central molecule of both the antioxidant defense system and the glyoxalase system, GSH is involved in both direct and indirect control of ROS and MG and their reaction products in plant cells, thus protecting the plant from HM-induced oxidative damage. Recent plant molecular studies have shown that GSH by itself and its metabolizing enzymes—notably glutathione S-transferase, glutathione peroxidase, dehydroascorbate reductase, glutathione reductase, glyoxalase I and glyoxalase II—act additively and coordinately for efficient protection against ROS- and MG-induced damage in addition to detoxification, complexation, chelation and compartmentation of HMs. The aim of this review is to integrate a recent understanding of physiological and biochemical mechanisms of HM-induced plant stress response and tolerance based on the findings of current plant molecular biology research.
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Heavy Metal Stress and Some Mechanisms of Plant Defense Response
Emamverdian, A., Ding, Y., Mokhberdoran, F., & Xie, Y. (2015) · The Scientific World Journal · doi:10.1155/2015/756120 · Cited by 917
Transfer of heavy metals through terrestrial food webs: a review
Gall, J. E., Boyd, R. S., & Rajakaruna, N. (2015) · Environmental Monitoring and Assessment · doi:10.1007/s10661-015-4436-3 · Cited by 893
Heavy Metal Contamination in Agricultural Soil: Environmental Pollutants Affecting Crop Health
Rashid, A., Schutte, B. J., Ulery, A., Deyholos, M. K., Sanogo, S., Lehnhoff, E. A., & Beck, L. (2023) · Agronomy · doi:10.3390/agronomy13061521 · Cited by 837
Cadmium stress in plants: A critical review of the effects, mechanisms, and tolerance strategies
El Rasafi, T., Oukarroum, A., Haddioui, A., Song, H., Kwon, E. E., Bolan, N., Tack, F. M. G., Sebastian, A., Prasad, M. N. V., & Rinklebe, J. (2022) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2020.1835435 · Cited by 601
Alleviation of Heavy Metal Stress in Plants and Remediation of Soil by Rhizosphere Microorganisms
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Metadata
- Authors
- Hossain, M. A., Piyatida, P., da Silva, J. A. T., & Fujita, M.
- Venue
- Journal of Botany
- Publisher
- Hindawi Limited
- Published
- 2012-04-02
- Volume
- 2012
- Pages
- 1-37
- ISSN
- 2090-0120 (ISSN-L)
- 2090-0139
- OpenAlex
- W2037090842
- Cited by
- 1,033
- References
- 9
- FWCI
- 50.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hossain, M. A., Piyatida, P., da Silva, J. A. T., & Fujita, M. (2012). Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Glutathione in Detoxification of Reactive Oxygen Species and Methylglyoxal and in Heavy Metal Chelation. Journal of Botany. https://doi.org/10.1155/2012/872875
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