Accelerated aging in major depression: the role of nitro-oxidative stress
Open accessAbstract
Nitro-oxidative stress (NOS) plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative disorders, and major depression (MD). The latter is a very frequent psychiatric illness characterized by accelerated aging, neurodegeneration, high comorbidity with age-related disorders, and premature mortality; all of these conditions find an explanation in an altered redox homeostasis. If aging, neurodegeneration, and major depression share a common biological base in their pathophysiology, common therapeutic tools could be investigated for the prevention and treatment of these disorders. As an example, antidepressants have been demonstrated to present neuroprotective and anti-inflammatory properties and to stimulate neurogenesis. In parallel, antioxidants that stimulate the antioxidant defense systems and interact with the monoaminergic system show an antidepressant-like activity. Further research on this topic could lead, in the near future, to the expansion of the therapeutic possibilities for the treatment of NOS-related disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MDD has been considered a syndrome of 'premature aging'.
“Major depressive disorder (MDD) has been considered a syndrome of “premature aging” (Heuser, 2002), and this notion has been reiterated in several recent reviews (Kinser and Lyon, 2013; Luca et al., 2013; Wolkowitz et al., 2011b).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Luca et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reactive oxygen species in cell signaling
Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,936 · see citing works
Cross-national epidemiology of DSM-IV major depressive episode
Bromet, E., Andrade, L. H., Hwang, I., Sampson, N. A., Alonso, J., de Girolamo, G., de Graaf, R., Demyttenaere, K., Hu, C., Iwata, N., et al. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-90 · Cited by 2,221 · see citing works
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Gene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works
Telomere states and cell fates
Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,372 · see citing works
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069 · see citing works
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894 · see citing works
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Flint Beal, M., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng1292-324 · Cited by 890 · see citing works
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works
NF-κB in neuronal plasticity and neurodegenerative disorders
Mattson, M. P., & Camandola, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11916 · Cited by 877 · see citing works
Oxidative stress in Alzheimer disease
Gella, A., & Durany, N. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.1.7402 · Cited by 459 · see citing works
Cognitive impairment in major depression
Marazziti, D., Consoli, G., Picchetti, M., Carlini, M., & Faravelli, L. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.08.046 · Cited by 448 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
The role of polyunsaturated fatty acids in restoring the aging neuronal membrane
Yehuda, S., Rabinovitz, S., LCARASSO, R., & Mostofsky, D. I. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00074-x · Cited by 404 · see citing works
Inflammation, Depression and Dementia: Are they Connected?
Leonard, B. E. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9385-y · Cited by 342 · see citing works
Cognitive Impairment of Rats Caused by Oxidative Stress and Aging, and Its Prevention by Vitamin E
Fukui, K., Nao-omi, O. M. O. I., Hayasaka, T., Shinkai, T., Suzuki, S., Abe, K., & Urano, S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02099.x · Cited by 318 · see citing works
Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview
Mazza, M., Pomponi, M., Janiri, L., Bria, P., & Mazza, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.07.010 · Cited by 306 · see citing works
Mancuso, C. (2006) · Frontiers in bioscience · doi:10.2741/2130 · Cited by 294 · see citing works
Cognitive Decline Is Associated with Systemic Oxidative Stress: The EVA Study
Berr, C., Balansard, B., Arnaud, J., Roussel, A., Alpérovitch, A., & EVA Study Group (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb02603.x · Cited by 279 · see citing works
Lower serum vitamin E concentrations in major depression
Maes, M. H. J., Vos, N. D., Pioli, R., Demedts, P., Wauters, A., Neels, H. M., & Christophe, A. B. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00121-4 · Cited by 274 · see citing works
Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology
Bolisetty, S., & Jaimes, E. A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036306 · Cited by 274 · see citing works
Khassaf, M. B., McArdle, A., Esanu, C., Vasilaki, A., McArdle, F., Griffiths, R. D., Brodie, D. A., & Jackson, M. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040303 · Cited by 273 · see citing works
The role of mitochondrial DNA mutations and free radicals in disease and ageing
Lagouge, M., & Larsson, N. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12055 · Cited by 270 · see citing works
The Role of Oxidative Stress in Depressive Disorders
Maria Michel, T., Pulschen, D., & Thome, J. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523554 · Cited by 268 · cited 2× · see citing works
“, prefrontal cortex) [36], loss of neuronal cells [35, 37], and reduced cerebral blood flow [38].”
BackgroundOxidative stress, mitochondrial DNA mutation, and apoptosis in aging.
Lee, H., & Wei, Y. (2007) · PubMed · Cited by 262 · see citing works
Cognitive deficits in major depression
Ravnkilde, B., Videbech, P., Clemmensen, K., Egander, A., Rasmussen, N. A., & Rosenberg, R. (2002) · Scandinavian Journal of Psychology · doi:10.1111/1467-9450.00292 · Cited by 249 · see citing works
Oxidative Stress in Atherosclerosis Development: The Central Role of LDL and Oxidative Burst
Peluso, I., Morabito, G., Urban, L., Ioannone, F., & Serafi, M. (2012) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153012803832602 · Cited by 238 · see citing works
Microglia in the aging brain: relevance to neurodegeneration
Luo, X.-G., Ding, J.-Q., & Chen, S.-D. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-12 · Cited by 236 · see citing works
Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases
Cencioni, C., Spallotta, F., Martelli, F., Valente, S., Mai, A., Zeiher, A., & Gaetano, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917643 · Cited by 218 · see citing works
Of sound mind and body: depression, disease, and accelerated aging
Wolkowitz, O. M., Reus, V. I., & Mellon, S. H. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/owolkowitz · Cited by 213 · see citing works
Inflammatory mechanisms in major depressive disorder
Raedler, T. J. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834b9db6 · Cited by 213 · see citing works
Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes
Calabrese, V., Cornelius, C., Leso, V., Salinaro, A. T., Ventimiglia, B., Cavallaro, M., Scuto, M. C., Rizza, S., Zanoli, L., Neri, S., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.003 · Cited by 177 · see citing works
Wikgren, M., Maripuu, M., Karlsson, T., Nordfjäll, K., Bergdahl, J., Hultdin, J., Del‐Favero, J., Roos, G., Nilsson, L., Adolfsson, R., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.015 · Cited by 173 · see citing works
Vitamin E and Neurodegenerative Disorders Associated with Oxidative Stress
Butterfield, D. A., Castegna, A., Drake, J., Scapagnini, G., & Calabrese, V. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290028954 · Cited by 170 · see citing works
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2009) · PubMed · Cited by 157 · see citing works
Mitochondrial dysfunction, oxidative stress, and major depressive disorder
Tobe, E. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s44282 · Cited by 156 · see citing works
The Psychiatric Manifestations of Mitochondrial Disorders: A Case and Review of the Literature
Anglin, R. E., Garside, S. L., Tarnopolsky, M. A., Mazurek, M. F., & Rosebush, P. I. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11r07237 · Cited by 150 · see citing works
The Role of ROS and RNS in Regulating Life and Death of Blood Monocytes
Baran, C. P., Zeigler, M. M., Tridandapani, S., & Marsh, C. B. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452866 · Cited by 145 · see citing works
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.014 · Cited by 144 · see citing works
Cell pathology in mood disorders
Rajkowska, G. (2002) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2002.35228 · Cited by 135 · cited 1× · see citing works
“, prefrontal cortex) [36], loss of neuronal cells [35, 37], and reduced cerebral blood flow [38].”
BackgroundSibille, E. L. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/esibille · Cited by 128 · see citing works
Nakamura, T., Cho, D., & Lipton, S. A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.032 · Cited by 113 · see citing works
Protein Homeostasis, Aging and Alzheimer’s Disease
Morawe, T., Hiebel, C., Kern, A., & Behl, C. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8246-0 · Cited by 103 · see citing works
Johnson, A. W., Jaaro-Peled, H., Shahani, N., Sedlak, T. W., Zoubovsky, S., Burruss, D., Emiliani, F., Sawa, A., & Gallagher, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307925110 · Cited by 96 · see citing works
(2009) · PubMed · Cited by 95 · see citing works
Budni, J., Zomkowski, A. D. E., Engel, D. F., Santos, D. B., dos Santos, A. A., Moretti, M., Valvassori, S. S., Ornell, F. R., Quevedo, J., Farina, M., et al. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.024 · Cited by 94 · see citing works
Lee, C. H., Park, J. H., Yoo, K., Choi, J. H., Hwang, I. K., Ryu, P. D., Kim, D., Kwon, Y., Kim, Y., & Won, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.03.015 · Cited by 93 · see citing works
Nunes, S. O. V., Vargas, H. O., Prado, E., Barbosa, D. S., de Melo, Moylan, S., Dodd, S., & Berk, M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.014 · Cited by 92 · see citing works
Biomarkers of oxidative/nitrosative stress: an approach to disease prevention.
Ogino, K., & Wang, D.-H. (2007) · PubMed · doi:10.18926/amo/32871 · Cited by 92 · see citing works
Oxidative Stress and the Aging Brain
Vila, J., Gemma, C., Bachstetter, A. D., & Bickford, P. C. (2007) · Frontiers in neuroscience · doi:10.1201/9781420005523.ch15 · Cited by 88 · see citing works
Smaga, I., Pomierny, B., Krzyżanowska, W., Pomierny-Chamioło, L., Miszkiel, J., Niedzielska, E., Ogorka, A. Z. T., & Filip, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.018 · Cited by 85 · see citing works
Hashioka, S., McGeer, P. L., Monji, A., & Kanba, S. (2009) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152409787601897 · Cited by 82 · see citing works
Hamazaki, K., Hamazaki, T., & Inadera, H. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.04.012 · Cited by 72 · see citing works
Anticipated brain molecular aging in major depression
Douillard-Guilloux, G., Guilloux, J.-P., Lewis, D. A., & Sibille, E. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.040 · Cited by 62 · see citing works
McNamara, R. K., & Liu, Y. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.08.021 · Cited by 59 · see citing works
Orosz, A., Jann, K., Federspiel, A., Horn, H., Höfle, O., Dierks, T., Wiest, R., Strik, W. K., Müller, T., & Walther, S. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0101 · Cited by 52 · see citing works
Gerzson, M. F. B., Victoria, F. N., Radatz, C. S., de Gomes, M. G., Boeira, S. P., Jacob, R. G., Alves, D. A. C., Jessé, C. R., & Savegnago, L. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.016 · Cited by 48 · see citing works
Neuroprotective effects of antidepressant and mood stabilizing drugs
Young, L. T. (2002) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0201 · Cited by 46 · see citing works
Seven, A., Aslan, M., İncir, S., et al. (2013) · Folia Neuropathologica · doi:10.5114/fn.2013.34197 · Cited by 36 · see citing works
Jessé, C. R., Wilhelm, E. A., Bortolatto, C. F., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.023 · Cited by 35 · see citing works
Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review
Kinser, P. A., & Lyon, D. (2013) · Nursing Research and Practice · doi:10.1155/2013/469070 · Cited by 34 · see citing works
Chronic depression as a model disease for cerebral aging
Bewernick, B. H., & Schlaepfer, T. E. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/bbewernick · Cited by 31 · see citing works
Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds
KLANDORF, H., & Van, K. (2012) · InTech eBooks · doi:10.5772/33879 · Cited by 21 · see citing works
Özalay, Ö., Çallı, C., Kitiş, Ö., Eker, M. C., Eker, Ö. D., Ozan, E., Coburn, K. L., & Gönül, A. S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.040 · Cited by 17 · see citing works
Nitrosative Stress in Aging – Its Importance and Biological Implications in NF-κB Signaling
Ljubuncic, P., Gochman, E., & Reznick, A. Z. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-602-3_2 · Cited by 12 · see citing works
Calandra, C., Luca, Prossimo, G., et al. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s39227 · Cited by 8 · see citing works
Self-citationNitrooxidative Stress and Neurodegeneration
Fiedorowicz, M., & Grieb, P. (2012) · InTech eBooks · doi:10.5772/37733 · Cited by 6 · see citing works
Prostaglandins Pathway as a Possible Biological Link Between Cancer and Major Depression
Luca, M., Luca, A., Celia, A., et al. (2014) · Current Angiogenesis · doi:10.2174/2211552802999140131105925 · Cited by 2 · see citing works
Self-citation[Depressive pseudodementia. Differential diagnosis or meeting point?].
Richly, P., Abdulhamid, P., & Bustin, J. (2013) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative stress, inflammation and treatment response in major depression
Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.031 · Cited by 473 · see citing works
Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
Luca, M., Di Mauro, M., Di Mauro, M., & Luca, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4730539 · Cited by 190 · see citing works
Self-citationCognitive Dysfunction in Depression – Pathophysiology and Novel Targets
Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works
- Authors
- Luca, M., Luca, A., & Calandra, C.
- Affiliations
- Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco" (IT)
- Corresponding author
- Calandra, Carmela
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-6
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC3848345
- OpenAlex
- W2137128909
- Cited by
- 37
- References
- 71
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 2
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, accelerated aging, nitro-oxidative stress, redox homeostasis, neurodegeneration, antidepressants, neuroprotection, neurogenesis, antioxidants, monoaminergic systems, anti-inflammatory activity, age-related comorbidities
- MeSH terms
- Aging, Depressive Disorder, Major, Major Depressive Disorder, Humans, Nerve Degeneration, Nitrosation, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
