Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?
Open accessAbstract
For thousands of years, humankind has used plants for therapeutics. Nowadays, there is a renewed public interest in naturally occurring treatments with minimal toxicity and diets related to health. Alterations in hippocampal neurogenesis have been recognized as an integral part of brain ischemia. Neuronal stem/progenitor cells in the hippocampus are positively and negatively regulated by intrinsic and extrinsic agents. One positive regulator of neurogenesis in the hippocampus is curcumin in the diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis and neuroprotection studies in brain ischemia and focuses on the role of curcumin in the diet. Data suggest that dietary intake of curcumin enhances neurogenesis. Recent studies performed in ischemic models have suggested that curcumin also has neuroprotective features. One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent ageing-associated changes in cellular proteins that lead to protein insolubility and aggregation after ischemia such as β-amyloid peptide and tau protein. Here, we also review the evidence from ischemic models that curcumin improves cognition and health span by overexpression of life supporting genes and preventing or delaying the onset of neurodegenerative changes. Available data provide evidence that curcumin induces neurogenesis and neuroprotection and may provide a novel therapeutic agent for both regenerative medicine and for the treatment of neurodegenerative diseases such as postischemic brain neurodegeneration with Alzheimer phenotype.
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Curcumin is a pleiotropic agent that targets immune-inflammatory and oxidative and nitrosative stress pathways and promotes neuroprotection and improved neurogenesis.
“Curcumin is a pleiotropic agent that targets immune-inflammatory and oxidative and nitrosative stress pathways and promotes neuroprotection and improved neurogenesis [165, 166].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [165]
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Cited by
Sorted by citations
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
- Authors
- Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Jabłoński, M., & Kocki, J.
- Affiliations
- Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
- Medical University of Lublin (PL)
- Corresponding author
- Pluta, Ryszard
- Venue
- Folia Neuropathologica
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2015
- Volume
- 2
- Issue
- 2
- Pages
- 89-99
- ISSN
- 1509-572X (ISSN-L)
- 1641-4640
- OpenAlex
- W2401222492
- Cited by
- 34
- References
- 72
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 1 · 2018: 5 · 2017: 8 · 2016: 4
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Folia Neuropathologica (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego, Polskiej Akademii Nauk
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- curcumin, hippocampal neurogenesis, neuroprotection, cerebral ischemia, Alzheimer's disease, amyloid-beta, tau protein, protein aggregation, cognitive function, healthspan, dietary supplementation, neurodegenerative diseases
- MeSH terms
- Alzheimer Disease, Animals, Brain, Brain Ischemia, Curcumin, Humans, Nerve Degeneration, Phenotype, Neuroprotective Agents, Neurogenesis
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