Neuroprotective Function of DJ-1 in Parkinson’s Disease

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,854

Mitochondrial Complex I Deficiency in Parkinson's Disease

Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsPreprint

Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,372

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Canet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115

Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061

DJ‐1 has a role in antioxidative stress to prevent cell death

Taira, T., Saito, Y., Niki, T., Iguchi‐Ariga, S. M. M., Takahashi, K., & Ariga, H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400074 · Cited by 866

DJ-1, a cancer- and Parkinson’s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818

DJ-1, a Novel Oncogene Which Transforms Mouse NIH3T3 Cells in Cooperation withras

Nagakubo, D., Taira, T., Kitaura, H., Ikeda, M., Tamai, K., Iguchi‐Ariga, S. M. M., & Ariga, H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6132 · Cited by 760

Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

Mizuno, Y., Ohta, S., Tanaka, M., Takamiya, S., Suzuki, K., SATO, T. A., Oya, H., Ozawa, T., & Kagawa, Y. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91141-8 · Cited by 735

Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?

Brembati, V., Faustini, G., Longhena, F., & Bellucci, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1197853 · Cited by 43

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients

Saito, Y., Ogawa, Y., Matsumura, A., Saigoh, K., Itoh, S., Sutou, K., Kobayashi, M., Mita, Y., Shichiri, M., Hisahara, S., et al. (2016) · Scientific Reports · doi:10.1038/srep30793 · Cited by 42

DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress

Yang, J., Kim, K. S., Iyirhiaro, G. O., Marcogliese, P. C., Callaghan, S. M., Qu, D., Kim, W. J., Slack, R. S., & Park, D. S. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1354-2 · Cited by 41

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria

Ozawa, K., Tsumoto, H., Miura, Y., Yamaguchi, J., Iguchi‐Ariga, S. M. M., Sakuma, T., Yamamoto, T., & Uchiyama, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-61287-6 · Cited by 43

Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models

Sanz, F., Solana‐Manrique, C., Muñoz, V. F. L., Calap-Quintana, P., Moltó, M. D., & Paricio, N. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.364 · Cited by 42

Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders

Lee, Y.-T. C., & Hsu, S. D. (2016) · Current Protein and Peptide Science · doi:10.2174/1389203717666160217143721 · Cited by 42

PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases

Kolísek, M., Montezano, A. C. I., Sponder, G., Anagnostopoulou, A., Vormann, J., Touyz, R. M., & Aschenbach, J. R. (2015) · Clinical Science · doi:10.1042/cs20150355 · Cited by 42

Sirtuins as modifiers of Parkinson's disease pathology

Tang, B. L. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23806 · Cited by 41

Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models

Alsharif, I., Boukhzar, L., Lefranc, B., Godefroy, D., Aury‐Landas, J., do Rego, J. L., do-Rego, J.-C., Naudet, F., Arabo, A., Chagraoui, A., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101839 · Cited by 42

Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster

Martinez-Perez, D. A., Jiménez-Del-Río, M., & Velez‐Pardo, C. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9899-x · Cited by 39

Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway

Xu, R., Xu, X.-W., Deng, Y., Ma, Z., Li, X., Zhao, L., Qiu, L.-J., Liu, H., & Chen, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.165 · Cited by 39

SUMOylation in α-Synuclein Homeostasis and Pathology

Savyon, M., & Engelender, S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00167 · Cited by 39

Analysis of proteins that rapidly change upon mechanistic/mammalian target of rapamycin complex 1 (mTORC1) repression identifies parkinson protein 7 (PARK7) as a novel protein aberrantly expressed in tuberous sclerosis complex (TSC)

Niere, F., Namjoshi, S., Song, E., Dilly, G. A., Schoenhard, G., Zemelman, B. V., Mechref, Y., & Raab-Graham, K. F. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.055079 · Cited by 38

Positional plasticity in regenerating Amybstoma mexicanum limbs is associated with cell proliferation and pathways of cellular differentiation

McCusker, C., Athippozhy, A., Díaz-Castillo, C., Fowlkes, C. C., Gardiner, D. M., & Voss, S. R. (2015) · BMC Developmental Biology · doi:10.1186/s12861-015-0095-4 · Cited by 38

Expression of DJ-1 in Neurodegenerative Disorders

Antipova, D., & Bandopadhyay, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6583-5_3 · Cited by 38

Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner

Henderson, Y. O., Bithi, N., Link, C., Yang, J., Schugar, R. C., Llarena, N. C., Brown, J. M., & Hine, C. (2021) · GeroScience · doi:10.1007/s11357-021-00330-4 · Cited by 39

Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.

Bortolozzi, A., Manashirov, S., Chen, A., & Artigas, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107873 · Cited by 37

Prefoldin prevents aggregation of α-synuclein

Takano, M., Tashiro, E., Kitamura, A., Maita, H., Iguchi‐Ariga, S. M. M., Kinjo, M., & Ariga, H. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.034 · Cited by 37

Common Mechanisms of Onset of Cancer and Neurodegenerative Diseases

Ariga, H. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00125 · Cited by 37

Post-translational modifications in neurodegeneration

Didonna, A., & Benetti, F. (2015) · AIMS Biophysics · doi:10.3934/biophy.2016.1.27 · Cited by 36

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson’s Disease

Johnson, W. M., Golczak, M., Choe, K., Curran, P. L., Miller, O. G., Yao, C., Wang, W., Lin, J., Milkovic, N. M., Ray, A., et al. (2016) · Biochemistry · doi:10.1021/acs.biochem.5b01132 · Cited by 37

A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family

Hanagasi, H. A., Giri, A., Kartal, E., Güven, G., Bılgıç, B., Hauser, A., Emre, M., Heutink, P., Basak, N. A., Gasser, T., et al. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.03.001 · Cited by 37

DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

Lazzari, F. D., Prag, H. A., Gruszczyk, A. V., Whitworth, A. J., & Bisaglia, M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101884 · Cited by 36

The Zebrafish, an Outstanding Model for Biomedical Research in the Field of Melatonin and Human Diseases

Aranda‐Martínez, P., Fernández‐Martínez, J., Ramírez‐Casas, Y., Guerra‐Librero, A., Rodríguez-Santana, C., Escames, G., & Acuña-Castroviejo, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137438 · Cited by 36

Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein

Takahashi-Niki, K., Kato-Ose, I., Murata, H., Maita, H., Iguchi‐Ariga, S. M. M., & Ariga, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666271 · Cited by 36

Role of DJ‐1 in Modulating Glycative Stress in Heart Failure

Shimizu, Y., Nicholson, C. K., Polavarapu, R., Pantner, Y., Husain, A., Naqvi, N., Chin, L., Li, L., & Calvert, J. W. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014691 · Cited by 34

Molecular imprinting synthetic receptor based sensor for determination of Parkinson's disease biomarker DJ-1

Kumar, M. D., Karthikeyan, M., Sharma, N., Vadthya, R., Vatsalarani, J., Kalivendi, S. V., & Karunakaran, C. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.107959 · Cited by 35

Mechanistic Nanotherapeutic Approach Based on siRNA-Mediated DJ-1 Protein Suppression for Platinum-Resistant Ovarian Cancer

Schumann, C., Chan, S., Khalimonchuk, O., Khal, S., Moskal, V., Shah, V. M., Alani, A. W. G., Taratula, O. R., & Taratula, O. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00205 · Cited by 36

Proteome analysis reveals roles of L-DOPA in response to oxidative stress in neurons

Jami, M., Pal, R., Hoedt, E., Neubert, T. A., Larsen, J. P., & Møller, S. G. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-93 · Cited by 34

Cyclosporine A Treatment Abrogates Ischemia‐Induced Neuronal Cell Death by Preserving Mitochondrial Integrity through Upregulation of the Parkinson's Disease‐Associated Protein DJ‐1

Tajiri, N., Borlongan, C. V., & Kaneko, Y. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12546 · Cited by 34

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

Morris, G., Walder, K. R., Carvalho, A. F., Tye, S. J., Lucas, K., Berk, M., & Maes, M. H. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.017 · Cited by 33

GDNF/RET signaling in dopamine neurons in vivo

Conway, J. A., Ince, S., Black, S., & Kramer, E. R. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03268-9 · Cited by 33

(De)Toxifying the Epigenetic Code

Zheng, Q., Prescott, N. A., Maksimovic, I., & David, Y. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00013 · Cited by 34

PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5

Lee, D., Kim, D.-H., Kim, S. T., Jeong, S., Kim, J. L., Shim, S. M., Heo, A. J., Song, X., Guo, Z. S., Bartlett, D. L., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1491212 · Cited by 33

Salidroside Protects Dopaminergic Neurons by Preserving Complex I Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway

Li, R., Wang, S., Li, T., Wu, L., Fang, Y., Yang, F., Zhang, L., Chen, J., & Wang, X. (2019) · Parkinson s Disease · doi:10.1155/2019/6073496 · Cited by 33

The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells

Bahmed, K., Boukhenouna, S., Karim, L., Andrews, T., Lin, J., Powers, R., Wilson, M. A., Lin, C.-R., Messier, E. M., Reisdorph, N. A., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1833-5 · Cited by 36

Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1

Jun, Y. W., & Kool, E. T. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.07.016 · Cited by 37

Oxidative inactivation of the endogenous antioxidant protein DJ-1 by the food contaminants 3-MCPD and 2-MCPD

Buhrke, T., Voß, L., Briese, A., Stephanowitz, H., Krause, E., Braeuning, A., & Lampen, A. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2027-5 · Cited by 33

DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol–mediated cardioprotection against hypoxia/reoxygenation–induced oxidative stress

Zhang, Y., Li, X., Zhao, L., Duan, G., Xiao, L., & Chen, H. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.094 · Cited by 33

Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders

Nakamura, T., Oh, C.-K., Zhang, X., Tannenbaum, S. R., & Lipton, S. A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0081 · Cited by 33

Intracellular metal binding and redox behavior of human DJ-1

Barbieri, L., Luchinat, E., & Banci, L. (2017) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-017-1509-5 · Cited by 32

Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease

Wang, Y., Xia, Y. F., Kou, L., Yin, S., Chi, X., Li, J., Sun, Y., Wu, J., Zhou, Q., Zou, W., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106224 · Cited by 33

Histamine and Receptors in Neuroinflammation: Their Roles on neurodegenerative diseases.

Zhou, Z., An, Q., Zhang, W., Li, Y.-X., Zhang, Q., & Yan, H.-J. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114964 · Cited by 32

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control

Strobbe, D., Robinson, A. A., Harvey, K., Rossi, L., Ferraina, C., de Biase, V., Rodolfo, C., Harvey, R. J., & Campanella, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00068 · Cited by 31

Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases

Gámez‐Valero, A., Guisado-Corcoll, A., Herrero‐Lorenzo, M., Solaguren‐Beascoa, M., & Martí, E. (2020) · Antioxidants · doi:10.3390/antiox9111095 · Cited by 34

Neurodegeneration: Impact of S-nitrosylated Parkin, DJ-1 and PINK1 on the pathogenesis of Parkinson's disease

Sircar, E., Raj, S. R., Wilson, M. A., Schlossmacher, M. G., & Sengupta, R. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108869 · Cited by 31

Critical Roles of Glutaredoxin in Brain Cells—Implications for Parkinson's Disease

Miller, O. G., & Mieyal, J. J. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7411 · Cited by 30

Update of Immunosenescence in Cerebral Small Vessel Disease

Jian, B., Hu, M., Cai, W., Zhang, B., & Lu, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585655 · Cited by 33

BAG5 Interacts with DJ‐1 and Inhibits the Neuroprotective Effects of DJ‐1 to Combat Mitochondrial Oxidative Damage

Qin, L., Tan, J., Zhang, H., Kousar, R., Lu, J., Tang, J., Jiang, B., Shen, X., Guo, J., Tang, B., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5094934 · Cited by 31

Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria – A proteomic study in an animal model of depression

Głombik, K., Stachowicz, A., Trojan, E., Olszanecki, R., Ślusarczyk, J., Suski, M., Chamera, K., Budziszewska, B., Lasoń, W., & Basta‐Kaim, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.014 · Cited by 30

Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice – A quantitative multireceptor study

Cremer, J. N., Amunts, K., Schleicher, A., Palomero‐Gallagher, N., Piel, M., Rösch, F., & Zilles, K. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.054 · Cited by 30

Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs

Froestl, W., Pfeifer, A., & Muhs, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121729 · Cited by 27

Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats

Kobeissy, F. H., Guingab-Cagmat, J. D., Zhang, Z., Moghieb, A. M., Glushakova, O. Y., Mondello, S., Boutté, A. M., Anagli, J. Y., Rubenstein, R., Bahmad, H. F., et al. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00198 · Cited by 29

PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases

Pap, D., Veres-Székely, A., Szebeni, B., & Vannay, Á. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126626 · Cited by 30

The expanding impact of methylglyoxal on behavior-related disorders

de Almeida, G. R. L., Szczepanik, J. C., Selhorst, I., Cunha, M. P., & Dafré, A. L. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110635 · Cited by 29

Rabs, Membrane Dynamics, and Parkinson's Disease

Tang, B. L. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25713 · Cited by 29

Virus-induced brain pathology and the neuroinflammation-inflammation continuum: the neurochemists view

Sian‐Hülsmann, J., & Riederer, P. F. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-023-02723-5 · Cited by 30

Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing

Artyukhova, M. A., Tyurina, Y. Y., Chu, C. T., Zharikova, T. M., Bayır, H., Kagan, V. E., & Timashev, P. S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.06.007 · Cited by 26

The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol

Bahmed, K., Lin, C.-R., Simborio, H. L. T., Karim, L., Aksoy, M. O., Kelsen, S. G., Tomar, D., Madesh, M., Elrod, J. W., Messier, E. M., et al. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00567.2018 · Cited by 27

Tracing the Evolution of Plant Glyoxalase III Enzymes for Structural and Functional Divergence

Kumar, B., Kaur, C., Pareek, A., Sopory, S. K., & Singla-Pareek, S. L. (2021) · Antioxidants · doi:10.3390/antiox10050648 · Cited by 27

Metabolic Alterations in a Drosophila Model of Parkinson’s Disease Based on DJ-1 Deficiency

Solana‐Manrique, C., Sanz, F., Torregrosa, I., Palomino‐Schätzlein, M., Hernández-Oliver, C., Pineda‐Lucena, A., & Paricio, N. (2022) · Cells · doi:10.3390/cells11030331 · Cited by 24

Up-regulation of caveolin-1 by DJ-1 attenuates rat pulmonary arterial hypertension by inhibiting TGFβ/Smad signaling pathway

Gao, W., Shao, R., Zhang, X., Liu, D., Liu, Y., & Fa, X. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.10.019 · Cited by 27

Understanding role of pesticides in development of Parkinson's disease: Insights from Drosophila and rodent models

Afsheen, S., Rehman, A. S., Jamal, A., Khan, N. H., & Parvez, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102340 · Cited by 28

PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress

Yin, L., Li, H., Liu, Z., Wu, W., Cai, J., Tang, C., & Dong, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.690697 · Cited by 27

Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology

Tsoporis, J. N., Drosatos, I.-A., Gupta, S., Amatullah, H., Izhar, S., dos Santos, C. C., Salpeas, V., Rigopoulos, A. G., Toumpoulis, I. K., Triantafyllis, A. S., et al. (2021) · Molecules · doi:10.3390/molecules26133795 · Cited by 26

Morphine-induced modulation of Nrf2-antioxidant response element signaling pathway in primary human brain microvascular endothelial cells

Reymond, S., Vujić, T., Schvartz, D., & Sanchez, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-08712-0 · Cited by 29

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Jiménez-Moreno, N., & Lane, J. D. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8865611 · Cited by 26

Chaperones and Proteostasis: Role in Parkinson’s Disease

Joshi, N., Raveendran, A., & Nagotu, S. (2020) · Diseases · doi:10.3390/diseases8020024 · Cited by 25

Diagnostic and prognostic blood biomarkers in vascular dementia: From the viewpoint of ischemic stroke

Hosoki, S., Tanaka, T., & Ihara, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105015 · Cited by 25

Dysregulated microRNAs in neural system: Implication in pathogenesis and biomarker development in Parkinson’s disease

Lu, J., Xu, Y. C., Quan, Z., Chen, Z., Sun, Z., & Qing, H. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.033 · Cited by 24

DJ-1 Protein and Its Role in the Development of Parkinson’s Disease: Studies on Experimental Models

Бунеева, О. А., & Medvedev, A. E. (2021) · Biochemistry (Moscow) · doi:10.1134/s000629792106002x · Cited by 25

Sirtuins as Modifiers of Huntington's Disease (HD) Pathology

Neo, S. H., & Tang, B. L. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.013 · Cited by 25

DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN

Niki, T., Endo, J., Takahashi-Niki, K., Yasuda, T., Okamoto, A., Saito, Y., Ariga, H., & Iguchi‐Ariga, S. M. M. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146641 · Cited by 24

Characterization of striatum-mediated behavior and neurochemistry in the DJ-1 knock-out rat model of Parkinson's disease

Giangrasso, D. M., Furlong, T. M., & Keefe, K. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104673 · Cited by 24

Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity

Aslam, K., & Hazbun, T. R. (2016) · Prion · doi:10.1080/19336896.2016.1141858 · Cited by 24

Propagation of Parkinson's disease by extracellular vesicle production and secretion

Shippey, L. E., Campbell, S. G., Hill, A. F., & Smith, D. P. (2022) · Biochemical Society Transactions · doi:10.1042/bst20220204 · Cited by 24

Transcriptional Activation of the Cholecystokinin Gene by DJ-1 through Interaction of DJ-1 with RREB1 and the Effect of DJ-1 on the Cholecystokinin Level in Mice

Yamane, T., Suzui, S., Kitaura, H., Takahashi-Niki, K., Iguchi‐Ariga, S. M. M., & Ariga, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078374 · Cited by 23

Imaging mass spectrometry allows for neuroanatomic-specific detection of gangliosides in the healthy and diseased brain

Wang, W. X., & Whitehead, S. N. (2020) · The Analyst · doi:10.1039/c9an02270h · Cited by 22

Mitochondrial Translocation of DJ-1 Is Mediated by Grp75: Implication in Cardioprotection of Resveratrol Against Hypoxia/Reoxygenation-Induced Oxidative Stress

Zhou, T., Wang, X., Huang, J., Deng, Y., Qiu, L.-J., Liu, H., Xu, X.-W., Ma, Z., Tang, L., & Chen, H. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000805 · Cited by 23

High levels of DJ ‐1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients

Kawate, T., Iwaya, K., Koshikawa, K., Moriya, T., Yamasaki, T., Hasegawa, S., Kaise, H., Fujita, T., Matsuo, H., Nakamura, T., et al. (2015) · Cancer Science · doi:10.1111/cas.12673 · Cited by 22

DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

Solti, K., Kuan, W., Fórizs, B., Kustos, G., Mihály, J., Varga, Z., Herberth, B., Moravcsik, É., Kiss, R., Kárpáti, M., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104629 · Cited by 22

Astrocytic MicroRNA in Ageing, Inflammation, and Neurodegenerative Disease

Chu, A. J., & Williams, J. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.826697 · Cited by 22

Generation of genome-edited dogs by somatic cell nuclear transfer

Kim, D. E., Lee, J., Ji, K., Park, K.-S., Kil, T.-Y., Koo, O. J., & Kim, M. K. (2022) · BMC Biotechnology · doi:10.1186/s12896-022-00749-3 · Cited by 22

Bio-effectiveness of the main flavonoids of Achillea millefolium in the pathophysiology of neurodegenerative disorders- a review.

Ayoobi, F., Shamsizadeh, A., Fatemi, I., Vakilian, A., Allahtavakoli, M., Hassanshahi, G., & Ahmadi, A. M. (2017) · PubMed Central · doi:10.22038/ijbms.2017.8827 · Cited by 22

The Role of the Antioxidant Protein DJ-1 in Type 2 Diabetes Mellitus

Eberhard, D., & Lammert, E. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6583-5_11 · Cited by 21

Pretreatment with Sodium Phenylbutyrate Alleviates Cerebral Ischemia/Reperfusion Injury by Upregulating DJ-1 Protein

Yang, R., Lei, J., Wang, B., Feng, D., Huang, L. H., Li, Y., Li, T., Zhu, G., Li, C., Lu, F., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00256 · Cited by 22

Molecular Symphony of Mitophagy: Ubiquitin‐Specific Protease‐30 as a Maestro for Precision Management of Neurodegenerative Diseases

Siwach, A., Patel, H., Khairnar, A., & Parekh, P. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70192 · Cited by 21

Protective role of anticancer drugs in neurodegenerative disorders: A drug repurposing approach

Advani, D., Gupta, R. V., Tripathi, R. S., Sharma, S., Ambasta, R. K., & Kumar, P. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104841 · Cited by 24

Protein modification in neurodegenerative diseases

Ramazi, S., Dadzadi, M., Darvazi, M., Seddigh, N., & Allahverdi, A. (2024) · MedComm · doi:10.1002/mco2.674 · Cited by 25

Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson’s Disease

Vazquez‐Mayorga, E., Díaz‐Sánchez, Á. G., Dagda, R. K., Domínguez-Solís, C., Dagda, R. Y., Coronado-Ramirez, C. K., & Martı́nez-Martı́nez, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081346 · Cited by 21

Structure of Cu(I)-Bound DJ-1 Reveals a Biscysteinate Metal Binding Site at the Homodimer Interface: Insights into Mutational Inactivation of DJ-1 in Parkinsonism

Puno, M. R., Patel, N. A., Møller, S. G., Robinson, C. V., Moody, P. C. E., & Odell, M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja406010m · Cited by 20

Global Proteome of LonP1+/− Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes

Key, J., Kohli, A., Bárcena, C., López-Otı́n, C., Heidler, J., Wittig, I., & Auburger, G. W. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184523 · Cited by 19

Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice

Lee, Y., Choi, G., Jeon, H., Kim, D., Ryu, S., Koo, S., Ha, K., & Kim, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0547-7 · Cited by 19

Mitochondrial Dysfunction as a Key Event during Aging: From Synaptic Failure to Memory Loss

Jara, C., Torres, A. K., Olesen, M. A., & Tapia‐Rojas, C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88445 · Cited by 20

DJ-1 attenuates the glycation of mitochondrial complex I and complex III in the post-ischemic heart

Pantner, Y., Polavarapu, R., Chin, L., Li, L., Shimizu, Y., & Calvert, J. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-98722-1 · Cited by 19

Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy

Glat, M. J., Ben‐Zur, T., Barhum, Y., & Offen, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148170 · Cited by 19

Identification of Altered Blood MicroRNAs and Plasma Proteins in a Rat Model of Parkinson’s Disease

Yadav, S. K., Pandey, A. K., Sarkar, S., Yadav, S., Parmar, D., & Yadav, S. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02636-y · Cited by 18

DJ-1 inhibits ferroptosis in cerebral ischemia-reperfusion via ATF4/HSPA5 pathway

Li, Y., Chen, T., Xue, Y., Wang, Y., Peng, L. H., Wang, C., & Yu, S. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105628 · Cited by 18

N‐homocysteinylation of DJ‐1 promotes neurodegeneration in Parkinson's disease

Guo, T., Zhou, L., Xiong, M., Xiong, J., Huang, J., Li, Y., Zhang, G., Chen, G., Wang, Z., Xiao, T., et al. (2024) · Aging Cell · doi:10.1111/acel.14124 · Cited by 18

Parkinson’s disease research: adopting a more human perspective to accelerate advances

Marshall, L. J., & Willett, C. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.09.010 · Cited by 19

Review Article

Niki, T., & Iguchi-ariga, S. M. M. (2016)

Pathogenesis of DJ-1/PARK7-Mediated Parkinson’s Disease

Skou, L. D., Johansen, S. K., Okarmus, J., & Meyer, M. (2024) · Cells · doi:10.3390/cells13040296 · Cited by 120

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

Biosa, A., Sandrelli, F., Beltramini, M., Greggio, E., Bubacco, L., & Bisaglia, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.005 · Cited by 94

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Kahle, P. J., Waak, J., & Gasser, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.003 · Cited by 324

Redox modulatory role of DJ-1 in Parkinson’s disease

Alshammari, Q. A. (2025) · Biogerontology · doi:10.1007/s10522-025-10227-w · Cited by 15