Neuroprotective Function of DJ-1 in Parkinson’s Disease

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,854

Mitochondrial Complex I Deficiency in Parkinson's Disease

Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsPreprint

Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,372

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Canet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115

Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061

DJ‐1 has a role in antioxidative stress to prevent cell death

Taira, T., Saito, Y., Niki, T., Iguchi‐Ariga, S. M. M., Takahashi, K., & Ariga, H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400074 · Cited by 866

DJ-1, a cancer- and Parkinson’s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818

DJ-1, a Novel Oncogene Which Transforms Mouse NIH3T3 Cells in Cooperation withras

Nagakubo, D., Taira, T., Kitaura, H., Ikeda, M., Tamai, K., Iguchi‐Ariga, S. M. M., & Ariga, H. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6132 · Cited by 760

Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

Mizuno, Y., Ohta, S., Tanaka, M., Takamiya, S., Suzuki, K., SATO, T. A., Oya, H., Ozawa, T., & Kagawa, Y. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91141-8 · Cited by 735

Methylation status of DJ-1 in leukocyte DNA of Parkinson’s disease patients

Tan, Y., Wu, L., Li, D., Liu, X., Ding, J., & Chen, S. (2016) · Translational Neurodegeneration · doi:10.1186/s40035-016-0052-6 · Cited by 18

Network analysis reveals common host protein/s modulating pathogenesis of neurotropic viruses

Ghosh, S., Mukherjee, S., Sengupta, N., Roy, A., Dey, D., Chakraborty, S., Chattopadhyay, D., Banerjee, A., & Basu, A. (2016) · Scientific Reports · doi:10.1038/srep32593 · Cited by 18

Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model

Yeo, H. J., Yeo, E. J., Shin, M. J., Choi, Y. J., Lee, C. H., Kwon, H. Y., Kim, D. W., Eum, W. S., & Choi, S. Y. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.7.101 · Cited by 18

A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity

Chovsepian, A., Berchtold, D., Winek, K., Mamrak, U., Álvarez, I. R., Dening, Y., Gołubczyk, D., Weitbrecht, L., Dames, C., Aillery, M., et al. (2021) · Advanced Science · doi:10.1002/advs.202103265 · Cited by 17

Kinetic evidence in favor of glyoxalase III and against deglycase activity of DJ ‐1

Choi, J., Tak, S., Jung, H., Cha, S., Hwang, E., Lee, D., Lee, J., Ryu, K., & Park, C. (2023) · Protein Science · doi:10.1002/pro.4641 · Cited by 19

Chemical Probe To Monitor the Parkinsonism-Associated Protein DJ-1 in Live Cells

Drechsel, J., Mandl, F. A. M., & Sieber, S. A. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00633 · Cited by 17

Therapeutic innovation in Parkinson’s disease: a 2020 update on disease-modifying approaches

Colombo, D., Pnevmatikou, P., Melloni, E., & Keywood, C. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1800454 · Cited by 18

A High-Throughput Chemical Screen in DJ-1β Mutant Flies Identifies Zaprinast as a Potential Parkinson's Disease Treatment

Sanz, F., Solana‐Manrique, C., Torres, J., Masiá, E., Vicent, M. J., & Paricio, N. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01134-2 · Cited by 19

Chapter 5 – “Parkinson's disease – A role of non-enzymatic posttranslational modifications in disease onset and progression?”

Schmidt, S. W., Weisenhorn, D. M. V., & Wurst, W. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101096 · Cited by 16

Neuroprotective role and mechanistic insights of DJ-1 dimerization in Parkinson’s disease

Lv, L., Zhang, H., Tan, J., & Wang, C. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02136-9 · Cited by 16

DJ‐1 regulates tyrosine hydroxylase expression through CaMKKβ/CaMKIV/CREB1 pathway in vitro and in vivo

Xu, X., Wang, R., Hao, Z., Wang, G., Mu, C., Ding, J., Sun, W., & Ren, H. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29000 · Cited by 16

An in silico analysis of deleterious single nucleotide polymorphisms and molecular dynamics simulation of disease linked mutations in genes responsible for neurodegenerative disorder

Pandey, S., Dhusia, K., Katara, P., Singh, S., & Gautam, B. (2019) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2019.1682047 · Cited by 16

Understanding the Pathogenesis Involved in Parkinson’s Disease and Potential Therapeutic Treatment Strategies

Dhanawat, M., Mehta, D. K., Gupta, S., & Das, R. (2020) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524920666200705222842 · Cited by 17

Non-enzymatic posttranslational protein modifications in protein aggregation and neurodegenerative diseases

Baldensperger, T., Preissler, M., & Becker, C. F. W. (2024) · RSC Chemical Biology · doi:10.1039/d4cb00221k · Cited by 17

Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis

Auburger, G. W. J., Gispert, S., & Brehm, N. (2016) · Parkinson s Disease · doi:10.1155/2016/4686185 · Cited by 15

The Parkinson’s disease DJ-1 / PARK7 gene controls peripheral neuronal excitability and painful neuropathy

Lee, S. H., Tonello, R., Lee, K., Roh, J., Prudente, A. S., Kim, Y. H., Park, C., & Berta, T. (2024) · Brain · doi:10.1093/brain/awae341 · Cited by 14

Redox modulatory role of DJ-1 in Parkinson’s disease

Alshammari, Q. A. (2025) · Biogerontology · doi:10.1007/s10522-025-10227-w · Cited by 15

Pyruvate Dehydrogenase Kinase Protects Dopaminergic Neurons from Oxidative Stress in Drosophila DJ-1 Null Mutants

Lee, Y., Kim, J., Kim, H., Han, J. E., Kim, S., Kang, K.-H., Kim, D., Kim, J., & Koh, H. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.5002 · Cited by 16

Protective role of DJ-1 in endotoxin-induced acute kidney injury

Leeds, J. T., Scindia, Y. M., Loi, V., Wlazlo, E., Ghias, E., Cechova, S., Portilla, D., Ledesma, J., & Swaminathan, S. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00064.2020 · Cited by 14

Betulin ameliorates neuronal apoptosis and oxidative injury via DJ ‐1/Akt/Nrf2 signaling pathway after subarachnoid hemorrhage

Lu, X., Yang, S., Lu, Q., Zhang, Y., Cha, Z., Huang, W., & Li, T. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70019 · Cited by 13

Involvement of Peroxiredoxin-3, Thioredoxin-2, and Protein Deglycase-1 in Cypermethrin-Induced Parkinsonism

Rajput, C., Sarkar, A., & Singh, M. P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02456-0 · Cited by 13

The possible role of methylglyoxal metabolism in cancer

Alfarouk, K. O., Alqahtani, S. S., Alshahrani, S., Morgenstern, J., Supuran, C. T., & Reshkin, S. J. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1972994 · Cited by 13

The three sisters of fate: Genetics, pathophysiology and outcomes of animal models of neurodegenerative diseases

Klonarakis, M., Vos, M. D., Woo, E. K., Ralph, L. T., Thacker, J. S., & Gil‐Mohapel, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104541 · Cited by 14

Exploring the link between Parkinson's disease and type 2 diabetes mellitus in Drosophila

Sanz, F., Solana‐Manrique, C., Lilao‐Garzón, J., Brito‐Casillas, Y., Descalzo, S. M., & Paricio, N. (2022) · The FASEB Journal · doi:10.1096/fj.202200286r · Cited by 13

Tat-DJ-1 enhances cell survival by inhibition of oxidative stress, NF-κB and MAPK activation in HepG2 cells

Jo, H. S., Yeo, E. J., Shin, M. J., Choi, Y. J., Yeo, H. J., Cho, S. B., Park, J. H., Lee, C. H., Eum, W. S., & Choi, S. Y. (2017) · Biotechnology Letters · doi:10.1007/s10529-017-2286-5 · Cited by 13

Physiology and Pathology of Neuroimmunology: Role of Inflammation in Parkinson’s Disease

Ortíz, G. G., González-Usigli, H., Pacheco-Moisés, F. P., Mireles-Ramírez, M. A., Sánchez-López, A. L., Torres-Sánchez, E. D., González-Renovato, E. D., Flores-Alvarado, L. J., Macías-Islas, M. Á., Rivero-Moragrega, P., et al. (2017) · InTech eBooks · doi:10.5772/intechopen.70377 · Cited by 13

What Have We Learned from Cerebrospinal Fluid Studies about Biomarkers for Detecting LRRK2 Parkinson’s Disease Patients and Healthy Subjects with Parkinson’s-Associated LRRK2 Mutations?

Loeffler, D. A., Aasly, J. O., LeWitt, P. A., & Coffey, M. P. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191630 · Cited by 13

A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism

Sarkar, A., & Singh, M. P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03591-6 · Cited by 12

Human coronavirus OC43 infection remodels connexin 43-mediated gap junction intercellular communication in vitro

Karmakar, S., & Sarma, J. D. (2024) · Journal of Virology · doi:10.1128/jvi.00478-24 · Cited by 12

Advances in development of biomarkers for brain damage and ischemia

Karimova, D., Rostami, E., Chubarev, V. N., Tarasov, V. V., Schiöth, H. B., & Rask‐Andersen, M. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09708-x · Cited by 12

Neural-induced human adipose tissue-derived stem cell secretome exerts neuroprotection against rotenone-induced Parkinson’s disease in rats

Ramalingam, M., Jang, S., Hwang, J., Cho, H., Kim, B. C., & Jeong, H. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04306-5 · Cited by 14

Molecular Mechanism Underlying Hypoxic Preconditioning-Promoted Mitochondrial Translocation of DJ-1 in Hypoxia/Reoxygenation H9c2 Cells

Deng, Y., Xiao, L., Zhao, L., Qiu, L.-J., Ma, Z., Xu, X.-W., Liu, H., Zhou, T., Wang, Y., Tang, L., et al. (2019) · Molecules · doi:10.3390/molecules25010071 · Cited by 12

DJ-1 as a deglycating enzyme: A unique function to explain a multifaceted protein?

Bisaglia, M., & Lazzari, F. D. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.219035 · Cited by 12

Cerebrospinal fluid levels of oxidative stress measured using diacron-reactive oxygen metabolites and biological antioxidant potential in patients with Parkinson’s disease and progressive supranuclear palsy

Takahashi, K., Iwaoka, K., Takahashi, K., Suzuki, Y., Taguchi, K., Yamahara, K., & Maeda, T. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135975 · Cited by 12

Nuclear DJ-1 Regulates DNA Damage Repair via the Regulation of PARP1 Activity

Wang, Z., Liu, Y., Li, Y., Wei, Q., Lin, R.-R., Kang, R., Ruan, Y., Lin, Z., Xue, N., Zhang, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108651 · Cited by 11

Oxidation of DJ-1 Cysteines in Retinal Pigment Epithelium Function

Bhattacharyya, S., Sturgis, J., Maminishkis, A., Miller, S. S., & Bonilha, V. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179938 · Cited by 11

Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson’s Disease Influence Sporadic Forms?

Lanore, A., Lesage, S., Mariani, L., Menon, P. J., Ravassard, P., Cheval, H., Corti, O., Brice, A., & Corvol, J. (2022) · Genes · doi:10.3390/genes13030479 · Cited by 11

CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology

Liao, S.-C., Kano, K., Phanse, S., Nguyen, M. K., Margolis, E. B., Fu, Y., Meng, J. X., Moutaoufik, M. T., Chatterton, Z., Saccon, T. D., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu0726 · Cited by 12

Ca2+ signalling: A common language for organelles crosstalk in Parkinson's disease

Peggion, C., Barazzuol, L., Poggio, E., Calí, T., & Brini, M. (2023) · Cell Calcium · doi:10.1016/j.ceca.2023.102783 · Cited by 10

DJ1 and microRNA‐214 act synergistically to rescue myoblast cells after ischemia/reperfusion injury

Ghaderi, S., Alidadiani, N., Soleimanirad, J., Heidari, H. R., Dilaver, N., Heim, C., Ramsperger-Gleixner, M., Baradaran, B., & Weyand, M. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26842 · Cited by 10

Comparison of Plasma PARK7 and NDKA Diagnostic Value in Acute Stroke

Tulantched, D. S. M., Zhao, M., & Feng, W.-X. (2019) · Future Science OA · doi:10.2144/fsoa-2018-0080 · Cited by 10

Parkin, PINK1 and DJ1 as possible modulators of mTOR pathway in ganglioglioma

Drapalo, K., & Jóźwiak, J. (2017) · International Journal of Neuroscience · doi:10.1080/00207454.2017.1366906 · Cited by 10

Identification of DJ-1-Associated Regions on Human Genes from SH-SY5Y Cells using Chromatin Immunoprecipitation Sequence Technique

Sugimoto, T. Y. N. (2014) · Molecular Biology · doi:10.4172/2168-9547.1000115 · Cited by 9

Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix

Osuagwu, N., Dölle, C., & Tzoulis, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219909 · Cited by 9

Potential biomarkers in hypoglycemic brain injury

Zhao, S., Liu, Z.-H., Ma, L., Yin, M., & Zhou, Y. (2023) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-023-00681-8 · Cited by 9

Redox Modulation of Mitochondrial Proteins in the Neurotoxicant Models of Parkinson's Disease

Sarkar, A., Rasheed, M. S. U., & Singh, M. P. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0106 · Cited by 9

Serum DJ-1 level is positively associated with improvements in some aspects of metabolic syndrome in Japanese women through lifestyle intervention

Yamane, T., Murao, S., Kozuka, M., Shimizu, M., Suzuki, J. S., Kubo, C., Yamaguchi, A., Musashi, M., Minegishi, Y., Izumi, M., et al. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.09.004 · Cited by 9

Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson’s disease model

Li, X., Guo, H. P., Wang, D. T., Sun, L. H., & Pan, S. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15026963 · Cited by 9

Superoxide signals for the mitophagy of dysfunctional mitochondria to maintain quality control

Curtis, W. M., & Bradshaw, P. C. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103979 · Cited by 8

Unravelling the genetic links between Parkinson’s disease and lung cancer

Leong, Y. Q., Koh, R. Y., Chye, S. M., & Ng, K. Y. (2023) · Biological Chemistry · doi:10.1515/hsz-2022-0228 · Cited by 8

Screening for the Key Proteins Associated with Rete Testis Invasion in Clinical Stage I Seminoma via Label-Free Quantitative Mass Spectrometry

Pulzová, L., Roška, J., Kalman, M., Kliment, J., Slávik, P., Smolková, B., Goffa, E., Jurkovičová, D., KULCSAR, L., Lešková, K., et al. (2021) · Cancers · doi:10.3390/cancers13215573 · Cited by 9

DJ‐1 plays an obligatory role in the cardioprotection of delayed hypoxic preconditioning against hypoxia/reoxygenation‐induced oxidative stress through maintaining mitochondrial complex I activity

Ding, H., Xu, X., Wang, H., Xiao, L., Zhao, L., Duan, G., Li, X., Ma, Z., & Chen, H. (2018) · Cell Biochemistry and Function · doi:10.1002/cbf.3326 · Cited by 8

Protein kinase A-induced phosphorylation at the Thr154 affects stability of DJ-1

Ko, Y. U., Kim, S.-J., Lee, J., Song, M., Park, K., Park, J. B., Cho, H., & Oh, Y. J. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.07.029 · Cited by 8

New Insights on Sperm Function in Male Infertility of Unknown Origin: A Multimodal Approach

Pacheco, R. I., Cristo, M. I., Anjo, S. I., Silva, A. F., Sousa, M. I., Tavares, R. S., Sousa, A. P., Almeida‐Santos, T., Moura­‐Ramos, M., Caramelo, F. J., et al. (2023) · Biomolecules · doi:10.3390/biom13101462 · Cited by 9

Olfactory Dysfunction: An early indicator of parkinson's disease

Chowdhury, D., Das, A., Mishra, M., Jayashree, Das, A., & Bodakhe, S. H. (2025) · Brain Disorders · doi:10.1016/j.dscb.2025.100209 · Cited by 10

PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Li, H., Liu, Z., Wang, Y., Wang, H., Cai, J., Tang, C., & Dong, Z. (2022) · Clinical Science · doi:10.1042/cs20220493 · Cited by 7

Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson’s disease phenotypes in vivo and in cell models

Tio, M., Wen, R., Choo, C. N., Tan, J. B., Chua, A., Xiao, B., Sundaram, J. R., Chan, C. H. S., & Tan, E. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01010-z · Cited by 7

Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2)

Stachowicz, A., Olszanecki, R., Suski, M., Głombik, K., Basta‐Kaim, A., Adamek, D., & Korbut, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020435 · Cited by 8

Free radicals impair the anti-oxidative stress activity of DJ-1 through the formation of SDS-resistant dimer

Yasuda, T., Niki, T., Ariga, H., & Iguchi‐Ariga, S. M. M. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1324201 · Cited by 7

Introduction/Overview

Ariga, H., & Iguchi‐Ariga, S. M. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6583-5_1 · Cited by 7

Chemoproteomic Profiling of Clickable Fumarate Probes for Target Identification and Mechanism of Action Studies

Zhang, L., Martin, J. G., Gao, B., Zeng, W., Couvertier, S. M., & Johnson, D. S. (2025) · ACS Chemical Biology · doi:10.1021/acschembio.4c00617 · Cited by 5

Parkinson’s associated protein DJ-1 regulates intercellular communication via extracellular vesicles in oxidative stress

Page, T. D., Musi, C. A., Bakker, S. E., Jenkins, D. R., Hill, E. J., Borsello, T., Milic, I., Devitt, A., & Repici, M. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02845-7 · Cited by 6

The Role of Protein S-Nitrosylation in Mitochondrial Quality Control in Central Nervous System Diseases

Qiu, F., Liu, Y., & Liu, Z. (2024) · Aging and Disease · doi:10.14336/ad.2024.0099 · Cited by 6

Genetic Models of Parkinson’s Disease

Kachidian, P., & Gubellini, P. (2020) · Neuromethods · doi:10.1007/978-1-0716-0912-5_3 · Cited by 6

Identification of Disease-Associated Variants by Targeted Gene Panel Resequencing in Parkinson's Disease

Daida, K., Funayama, M., Li, Y., Yoshino, H., Hayashida, A., Ikeda, A., Ogaki, K., Nishioka, K., & Hattori, N. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.576465 · Cited by 6

Computational discovery and assessment of non-synonymous single nucleotide polymorphisms from target gene pool associated with Parkinson's disease

Rath, S. N., Ray, M., & Patri, M. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100947 · Cited by 7

Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study

Göteson, A., Clements, C. C., Juréus, A., Joas, E., Larsson, J. H., Karlsson, R., Nordenskjöld, A., Pålsson, E., & Landén, M. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.11.005 · Cited by 6

Identification of the Protective Role of DJ-1 in Hypoglycemic Astrocyte Injury Using Proteomics

Deng, J., Zhao, F. L., Yu, X., Li, D., & Zhao, Y. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00514 · Cited by 6

Dp71Δ78‐79 dystrophin mutant stimulates neurite outgrowth in PC12 cells via upregulation and phosphorylation of HspB1

Merino‐Jiménez, C., Aragón, J., Ceja, V., Martinez, G. R., Cázares‐Raga, F. E., Chardonnet, S., Pionneau, C., Rendón, Á., & Montáñez, C. (2016) · PROTEOMICS · doi:10.1002/pmic.201500211 · Cited by 6

Biomarkers in cerebrospinal fluid for synucleinopathies, tauopathies, and other neurodegenerative disorders

Marques, T. M., van Rumund, A., Kuiperij, H. B., & Verbeek, M. M. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804279-3.00007-1 · Cited by 6

Overexpression of DJ-1 alleviates autosomal dominant polycystic kidney disease by regulating cell proliferation, apoptosis, and mitochondrial metabolism in vitro and in vivo

Li, Z., Zhou, J., Li, Y., Yang, F., Lian, X., & Liu, W. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-5761 · Cited by 6

Intersection of Redox Chemistry and Ubiquitylation: Post-Translational Modifications Required for Maintaining Cellular Homeostasis and Neuroprotection

Kane, E. I., Waters, K. L., & Spratt, D. E. (2021) · Cells · doi:10.3390/cells10082121 · Cited by 6

Ubiquitin Subproteome of Brain Mitochondria and Its Changes Induced by Experimental Parkinsonism and Action of Neuroprotectors

Бунеева, О. А., Medvedeva, M. V., Kopylov, A. T., & Medvedev, A. E. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919110117 · Cited by 6

Lactiplantibacillus plantarum as a Psychobiotic Strategy Targeting Parkinson’s Disease: A Review and Mechanistic Insights

Chen, W.-L., Deng, F.-S., & Tsai, Y.-C. (2025) · Nutrients · doi:10.3390/nu17193047 · Cited by 8

Long-term exposure to PM2.5 exacerbates dopaminergic neuronal loss through CpG hypermethylation induced down-regulation of PINK1 and DJ-1 genes

Du, X., Guan, L., Chen, C., Wang, X., & Geng, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-89422-1 · Cited by 5

Effects of endurance training on hippocampus DJ ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

Kurd, M., Dehnou, V. V., Tavakoli, S. A., & Gahreman, D. E. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12868 · Cited by 5

Role of Genes and Treatments for Parkinson’s Disease

Naz, F., & Siddique, Y. H. (2020) · The Open Biology Journal · doi:10.2174/1874196702008010047 · Cited by 5

Role of the Genus Cinnamomum in the Management of Neurodegenerative Diseases: Outcomes and Shortcomings

Kaur, R., & Shri, R. (2018) · Indian Journal of Pharmaceutical Sciences · doi:10.4172/pharmaceutical-sciences.1000448 · Cited by 6

A Review of the Recent Advances in the Pharmacological Management of Parkinson’s Disease

Li, A., Cha, A., Huang, M. Z., Dhami, S., & Pemminati, S. (2025) · Cureus · doi:10.7759/cureus.93123 · Cited by 5

Intersecting molecular pathways in Synucleinopathies and Amyloidogenesis: Exploring shared mechanisms and therapeutic potential

Kaur, J., Sharma, V., Khan, H., Singh, S., & Singh, T. G. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149568 · Cited by 4

Parkinson’s disease-associated 18 bp promoter variant of DJ-1 alters REST binding and regulates its expression

Pal, P., Roy, S., Chowdhury, A., Chatterjee, R., Ray, K., & Ray, J. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137051 · Cited by 4

DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression

Tsoporis, J. N., Amatullah, H., Gupta, S., Izhar, S., Ektesabi, A. M., Vaswani, C. M., Desjardins, J., Kabir, G., Monteiro, A. P. T., Varkouhi, A. K., et al. (2023) · Antioxidants · doi:10.3390/antiox12030561 · Cited by 4

Development and use of DJ-1 affinity microcolumns to screen and study small drug candidates for Parkinson's disease

Jones, J. C., Lin, J., Sharmeen, S., Rahman, M., Truong, H. H., Chern, T., Wilson, M. A., & Hage, D. S. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.343520 · Cited by 4

Cyclophilin 1 (Cyp1) mutation ameliorates oxidative stress-induced defects in a Drosophila DJ-1 null mutant

Kim, E. Y., Kang, K.-H., & Koh, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.014 · Cited by 4

Backbone resonance assignment of human DJ-1 in the reduced state and in the cysteine sulfinic acid state

Barbieri, L., & Luchinat, E. (2019) · Biomolecular NMR Assignments · doi:10.1007/s12104-019-09908-8 · Cited by 4

Mitochondria and Brain Disorders

Baloyannis, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77668 · Cited by 4

Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication

Tsai, C., Wu, C.-J., Wu, J. C. C., Fang, C., Huang, Y., & Dai, K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104791 · Cited by 4

Regulatory Non-coding RNAs Involved in Oxidative Stress and Neuroinflammation: An Intriguing Crosstalk in Parkinson’s Disease

Khish, N. S., Ghiasizadeh, P., rasti, A., Moghimi, O., Zadeh, A. Z., Bahiraee, A., & Ebrahimi, R. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230817102135 · Cited by 4

Gene Expression Changes in a Model Neuron Cell Line Exposed to Autoantibodies from Patients with Traumatic Brain Injury and/or Type 2 Diabetes

Zimering, M. B., Delic, V., & Citron, B. A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02428-4 · Cited by 4

Bridging the gap in Parkinson’s disease research: from general pathophysiology to advanced 3d cell culture models

Keleş, B. S., Rumman, B., Samarie, M. A. J. A., Özdemir, Y., Çakmak, Ö. Ö., Akyoldaş, G., Ertan, S., & Sokullu, E. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02461-z · Cited by 3

Белок DJ-1 и его роль в развитии болезни Паркинсона: исследования на экспериментальных моделях

Бунеева, О. А., & Medvedev, A. E. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521060026 · Cited by 3

Modifications of DJ-1 in which pI shifts to acidic in red blood cells a potential biomarker for Parkinson’s disease at early stages

Matsuda, K., Mita, Y., Saigoh, K., Saito, Y., & Noguchi, N. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2430536 · Cited by 3

Genetics of Parkinson’s Disease: The Role of Copy Number Variations

Cognata, V. L., D’Agata, V., Cavalcanti, F., & Cavallaro, S. (2016) · InTech eBooks · doi:10.5772/62881 · Cited by 3

Role of Animal Models in Parkinson's Disease (PD): What Role They Play in Preclinical Translational Research

Srivastava, R., Dilnashin, H., Kapoor, D. U., Aparna, S., Heidarli, E., Singh, S. P., & Jain, V. K. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230223150347 · Cited by 5

Investigation of Phytochemical and Antidepressants Activity of Cinnamon Powder Extract

Santosh Kumar, S. R., Bongale, M. M., Maurya, C., Yuvraj, Y., Gupta, V. L., Dubey, S. A., & Sarwade, P. P. (2024) · Journal for Research in Applied Sciences and Biotechnology · doi:10.55544/jrasb.3.5.16 · Cited by 4

Therapeutics in Neurodegenerative Disorders: Emerging Compounds of Interest

Babu, G. N., & Gupta, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-60408-4_4 · Cited by 4

Granulocyte-colony stimulating factor, a potential candidate for the treatment of Parkinson's disease

Yuan, J., Xue, L., & Jin-Peng, R. E. N. (2022) · Journal of Neurosurgical Sciences · doi:10.23736/s0390-5616.21.05314-5 · Cited by 3

Non‐human primate models of Parkinson's disease: Decoding pathogenesis and advancing therapies

Zhang, S., Yuan, L., Wu, Z., Du, X., Kubiak, J. Z., Yue, F., Yan, X., Jiang, G., & Huang, Y. (2025) · Brain‐X · doi:10.1002/brx2.70032 · Cited by 2

Preparation of epitope molecularly imprinted fluorescent probes for highly sensitive detection of DJ-1 protein in serum

Tian, M., Cheng, Y., Wang, S., Yan, S., Zhang, M., Ge, S., He, Y., & Wei, Z.-H. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.116301 · Cited by 2

Miro1 in Parkinson’s Disease: A Key Regulator of Mitochondrial Homeostasis and Neurodegeneration

Singh, G., Kaur, S., & Aran, K. R. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08917-w · Cited by 2

Review Article

Niki, T., & Iguchi-ariga, S. M. M. (2016)

Pathogenesis of DJ-1/PARK7-Mediated Parkinson’s Disease

Skou, L. D., Johansen, S. K., Okarmus, J., & Meyer, M. (2024) · Cells · doi:10.3390/cells13040296 · Cited by 120

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

Biosa, A., Sandrelli, F., Beltramini, M., Greggio, E., Bubacco, L., & Bisaglia, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.005 · Cited by 94

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Kahle, P. J., Waak, J., & Gasser, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.003 · Cited by 324

Redox modulatory role of DJ-1 in Parkinson’s disease

Alshammari, Q. A. (2025) · Biogerontology · doi:10.1007/s10522-025-10227-w · Cited by 15