The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation
Open accessAbstract
Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and adipogenic lineage commitment and differentiation, a theoretical inverse relationship exists, such that differentiation towards an osteoblast phenotype occurs at the expense of an adipocytic phenotype. This balance is regulated by numerous, intersecting signaling pathways that converge on the regulation of two main transcription factors: peroxisome proliferator-activated receptor-γ(PPAR γ) and Runt-related transcription factor 2 (Runx2). These two transcription factors, PPAR γ and Runx2, are generally regarded as the master regulators of adipogenesis and osteogenesis. This review will summarize signaling pathways that govern MSC fate towards osteogenic or adipocytic differentiation. A number of signaling pathways follow the inverse balance between osteogenic and adipogenic differentiation and are generally proosteogenic/antiadipogenic stimuli. These include β-catenin dependent Wnt signaling, Hedgehog signaling, and NELL-1 signaling. However, other signaling pathways exhibit more context-dependent effects on adipogenic and osteogenic differentiation. These include bone morphogenic protein (BMP) signaling and insulin growth factor (IGF) signaling, which display both proosteogenic and proadipogenic effects. In summary, understanding those factors that govern osteogenic versus adipogenic MSC differentiation has significant implications in diverse areas of human health, from obesity to osteoporosis to regenerative medicine.
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Cites
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“Indeed, the perivascular origin of MSC has become an increasingly accepted theory [10–13].”
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Cited by
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Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
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The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway
Hung, C.-C., Chaya, A., Liu, K., Verdelis, K., & Sfeir, C. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.06.001 · Cited by 237
Inflammation, mesenchymal stem cells and bone regeneration
Liu, H., Li, D., Zhang, Y., & Li, M. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1643-3 · Cited by 160
Metadata
- Authors
- James, A. W.
- Venue
- Scientifica
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-17
- ISSN
- 2090-908X (ISSN-L)
- OpenAlex
- W2105016447
- Cited by
- 493
- References
- 13
- FWCI
- 16.86
- Type
- journal article
- Language
- en
- Open access
- gold
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