Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses

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Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α 1 1Abbreviations: EGb 761, Ginkgo biloba extract; LPS, lipopolysaccharide; ROIs, reactive oxygen intermediates; TNF, tumor necrosis factor; IL, interleukin; COX, cyclooxygenase; iNOS, inducible nitric oxide synthase; TLR, Toll-like receptor; LBP, lipid binding protein; NF-κB, nuclear factor-κB; IKK, IκB kinase; AP-1, activator protein 1; ATF, activating transcription factor; CRE, cyclic AMP response element; CREB, cyclic AMP binding protein; C/EBP, CCAAT/enhancer binding protein; ARE, AU-rich element; -UTR, untranslated region; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-related kinase; MEKK, MAPK/ERK kinase kinase; MEK, MAPK/ERK kinase; JNK/SAPK, Jun N terminal kinase/stress-activated protein kinase; EMSA, electrophoretic mobility shift assay; DTT, dithiothreitol; PMSF, phenylmethylsulfonyl fluoride; and ECL, enhanced chemiluminescence.

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PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities

Hossen, M. J., Cho, J. Y., & Kim, D. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.06.019 · Cited by 41 · see citing works

Nuclear factor kappa-B- and activator protein-1-mediated immunostimulatory activity of compound K in monocytes and macrophages

Yang, W. S., Yi, Y., Kim, D., Kim, M. H., Park, J. G., Kim, E., Lee, S. Y., Yoon, K., Kim, J., Park, J., et al. (2016) · Journal of Ginseng Research · doi:10.1016/j.jgr.2016.06.004 · Cited by 41 · see citing works

Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation

Yun, M., & Yi, Y. (2019) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.12.006 · Cited by 40 · see citing works

Mitochondrial Targeting of the Enteropathogenic Escherichia coli Map Triggers Calcium Mobilization, ADAM10-MAP Kinase Signaling, and Host Cell Apoptosis

Ramachandran, R., Spiegel, C., Keren, Y., Danieli, T., Melamed-Book, N., Pal, R., Zlotkin-Rivkin, E., Rosenshine, I., & Aroeti, B. (2020) · mBio · doi:10.1128/mbio.01397-20 · Cited by 33 · see citing works

BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells

Kim, E., Yi, Y., Son, Y., Han, S. Y., Kim, D. H., Nam, G., Hossain, M. A., Kim, J., Park, J., & Cho, J. Y. (2018) · Journal of Ginseng Research · doi:10.1016/j.jgr.2018.02.001 · Cited by 40 · see citing works

Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways

Lee, J.-O., Yang, Y., Yu, T., Yi, Y., & Cho, J. Y. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2022.02.004 · Cited by 40 · see citing works

Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model

Morin, S., Simard, M., Rioux, G., Julien, P., & Pouliot, R. (2022) · Cells · doi:10.3390/cells11091513 · Cited by 39 · see citing works

AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens

Yang, W. S., Kim, D., Yi, Y., Kim, J. H., Jeong, H. Y., Hwang, K., Kim, J., Park, J., & Cho, J. Y. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.03.001 · Cited by 39 · see citing works

Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model

Kumari, A., Singh, D. K., Dash, D., & Singh, R. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0544-3 · Cited by 39 · see citing works

Health implication of vitamin D on the cardiovascular and the renal system

AL-Ishaq, R. K., Kubatka, P., Brozmanova, M., Gazdíková, K., Čaprnda, M., & Büsselberg, D. (2019) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1628064 · Cited by 39 · see citing works

Polystyrene nanoplastics induce apoptosis of human kidney proximal tubular epithelial cells via oxidative stress and MAPK signaling pathways

Zhu, Z., Liao, R., Shi, Y., Li, J., Cao, J., Liao, B., Wu, J., & Li, G. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30155-x · Cited by 38 · see citing works

Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts

Achudhan, D., Chang, S. L., Liu, S., Lin, Y., Huang, W., Wu, Y., Huang, C., Tsai, C., Ko, C., Kuo, Y., et al. (2022) · Food & Nutrition Research · doi:10.29219/fnr.v66.8645 · Cited by 38 · see citing works

Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation

Schwarz, A., Bonaterra, G., Schwarzbach, H., & Kinscherf, R. (2017) · Journal of Biomedical Sciences · doi:10.1186/s12929-017-0320-5 · Cited by 35 · see citing works

Severity of pancreatitis-associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocynin

Deng, W., Abliz, A., Xu, S., Sun, R., Guo, W., Shi, Q., Yu, J., & Wang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5678 · Cited by 37 · see citing works

Exploring the Role of Licorice and Its Derivatives in Cell Signaling Pathway NF‐ κ B and MAPK

Fatima, I., Sahar, A., Tariq, A., Naz, T., & Usman, M. (2024) · Journal of Nutrition and Metabolism · doi:10.1155/2024/9988167 · Cited by 38 · see citing works

IL-34 promotes foam cell formation by enhancing CD36 expression through p38 MAPK pathway

Liu, Q., Fan, J. J., Bai, J., Peng, L., Zhang, T., Deng, L., Wang, G., Zhao, Y., Nong, J.-G., Zhang, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-35485-2 · Cited by 36 · see citing works

Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells

Serreli, G., Naitza, M. R., Zodio, S., Leoni, V. P., Spada, M., Melis, M. P., Boronat, A., & Deiana, M. (2021) · Nutrients · doi:10.3390/nu13093152 · Cited by 36 · see citing works

Anti-inflammatory role of Artemisia argyi methanol extract by targeting the caspase-11 non-canonical inflammasome in macrophages

Kim, Y. B., Cho, H.-J., & Yi, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116231 · Cited by 36 · see citing works

Review Article Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Sung, G.-H., Yoo, B. C., & Cho, J. Y. (2016)

Anti-inflammatory roles of p38α MAPK in macrophages are context dependent and require IL-10

Raza, A., Crothers, J. W., McGill, M. M., Mawe, G. M., Teuscher, C., & Krementsov, D. N. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ab0116-009rr · Cited by 41 · see citing works

Function and inhibition of P38 MAP kinase signaling: Targeting multiple inflammation diseases

Wang, J., Liu, Y., Guo, Y., Liu, C., Yang, Y., Fan, X., Yang, H., Liu, Y., & Ma, T. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115973 · Cited by 115 · see citing works

Therapeutic regulation of cytokine signalling by inhibitors of p38 mitogen-activated protein kinase

Owens, R. J., & Lumb, S. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8450-1_10 · Cited by 2 · see citing works

p38 Pathway Kinases as Anti-inflammatory Drug Targets

Schindler, J. F., Monahan, J. B., & Smith, W. G. (2007) · Journal of Dental Research · doi:10.1177/154405910708600902 · Cited by 228 · see citing works