Decellularized scaffold and its elicited immune response towards the host: The underlying mechanism and means of immunomodulatory modification
Abstract
The immune response of the host towards a decellularized scaffold is complex.
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Immunomodulatory scaffolds should have properties that will not negatively interfere with the host immune system and cause extensive scar formation.
“Immunomodulatory scaffolds should have properties that will not negatively interfere with the host immune system and cause extensive scar formation.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [209]
Conversely, they ought to modulate immune cells together with the degree of inflammation and thus hinder fibrosis of the tissue.
“Conversely, they ought to modulate immune cells together with the degree of inflammation and thus hinder fibrosis of the tissue [209].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [209]
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Tan, J., Zhang, Q.-Y., Huang, L.-P., Huang, K., & Xie, H.-Q.
- Affiliations
- Sichuan University (CN)
- Laboratory of Stem Cell and Tissue Engineering
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 9
- Issue
- 14
- Pages
- 4803-4820
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W3161701006
- Cited by
- 57
- References
- 20
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 18 · 2023: 8 · 2022: 13 · 2021: 3
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2017YFC1104702)
- Sichuan Province Science and Technology Support Program (2019JDRC0020)
- West China Hospital, Sichuan University (ZYJC18002)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- decellularized scaffolds, host immune response, immunomodulation, immune cell polarization, pro-inflammatory response, scaffold surface modification, bioactive peptides, cytokines, biophysical properties, tissue engineering
- MeSH terms
- Biocompatible Materials, Extracellular Matrix, Immunity, Wound Healing, Tissue Engineering, Tissue Scaffolds
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